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Mouse Clostridium botulinum Neurotoxin Type C1 Heavy Chain Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS6000269 anti-Clostridium botulinum Neurotoxin Type C1 Heavy Chain antibody
Unit / Price
0.1 mg  /  $630 +1 FREE 8GB USB
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 Product Name   

Clostridium botulinum Neurotoxin Type C1 Heavy Chain, Monoclonal Antibody

★Popular Item★
 Also Known As   

Clostridium botulinum Neurotoxin Type C1 Heavy Chain (BoNT-C1)

 Product Synonym Names    Anti -Clostridium botulinum Neurotoxin Type C1 Heavy Chain (BoNT-C1)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    11n49
 Host    Mouse
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 Specificity    Recognizes C. botulinum BoNT-C1 Heavy Chain. In direct ELISA, does not crossreact with the light chains of BoNT-A, -B,-C1,-D, -E, -F, -G, or heavy chains of BoNT-D or -G.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.
 Concentration    ~0.5mg/ml (after reconstitution) (lot specific)
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 Immunogen    Recombinant protein corresponding to aa866-1291 from C. botulinum BoNT-C1 heavy chain, expressed in E. coli (P18640).
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-Clostridium botulinum Neurotoxin Type C1 Heavy Chain antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Clostridium botulinum Neurotoxin Type C1 Heavy Chain antibody

   BoNT-C1 (Botulinum neurotoxin C1 [heavy chain]) is a 100kD C-terminal fragment of the C1 Clostridum botulinum neurotoxin (holo)precursor. It constitutes a nonenzymatic part of a Zn2+-dependent M27 family endoprotease that potently blocks neurosecretion. The inactive 1291aa, 150kD C1 precursor is cleaved between Lys449Thr450 to generate a heterodimeric toxin held together by a preexisting interchain disulfide bond between Cys437 and Cys453. The 100kD C-terminus (heavy chain) acts as a ligand for neuronal membrane ecto-acceptors, inducing its translocation and internalization. The 50kD N-terminal light chain acts as an intracellular peptidase that cleaves SNAP-25 and syntaxin. This is suggested to block noradrenalin release from a readily releasable pool of vesicles. Over aa866-1291, the C1 heavy chain shares less than 40aa identity with the D-type neurotoxin heavy chain.
 Product Categories/Family for anti-Clostridium botulinum Neurotoxin Type C1 Heavy Chain antibody    Antibodies; Abs to Infectious Disease
 Applications Tested/Suitable for anti-Clostridium botulinum Neurotoxin Type C1 Heavy Chain antibody   

ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-Clostridium botulinum Neurotoxin Type C1 Heavy Chain antibody    Suitable for use in Direct ELISA, Western Blot and Immunoprecipitation.
Dilution: Western Blot: 1ug/ml
Immunoprecipitation: 25ug/ml
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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