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anti-Clu antibody :: Mouse Clusterin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS140166 anti-Clu antibody
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Clusterin, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse Anti Human Clusterin

 Product Synonym Names    Clusterin Antibody; Clusterin, Mouse Anti Human; CLI; AAG4; KUB1; SGP2; SGP-2; SP-40; TRPM2; MGC24903; Complement-associated protein SP-40; 40; Complement cytolysis inhibitor; NA1/NA2; Apolipoprotein J; Apo-J; Testosterone-repressed prostate message 2; TRPM-2; Clusterin
 Product Gene Name   

anti-Clu antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Monoclonal
 Isotype    IgG1 heavy chain and kappa light chain
 Clone Number    P1A11AT
 Host    Mouse
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 Purity/Purification    Clusterin antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
 Form/Format    1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
Sterile Filtered clear solution.
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 Immunogen    Anti-human Clusterin mAb, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with Recombinant human Clusterin amino acids 1-333 purified from E Coli.
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 Preparation and Storage    For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
12 months at -20 degree C. 1 month at 4 degree C.
 Other Notes    Small volumes of anti-Clu antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Clu antibody

   Introduction: Clusterin also named Apolipoprotein J (APO-J) is a 75-80 kD disulfide-linked heterodimeric protein containing about 30% of N-linked carbohydrate rich in sialic acid but truncated forms targeted to the nucleus have also been identified. The precursor polypeptide chain is cleaved proteolytically to remove the 22-mer secretory signal peptide and subsequently between residues 227/228 to generate the ? and ? chains. These are assembled in anti-parallel to give a heterodimeric molecule in which the cysteine-rich centers are linked by five disulfide bridges and are flanked by two predicted coiled-coil ? -helices and three predicted amphipathic a-helices. Across a broad range of species clusterin shows a high degree of sequence homology ranging from 70% to 80%. It is nearly ubiquitously expressed in most mammalian tissues and can be found in plasma, milk, urine, cerebrospinal fluid and semen. It is able to bind and form complexes with numerous partners such as immunoglobulins, lipids, heparin, b
 Product Categories/Family for anti-Clu antibody    ANTI-HUMAN CYTOKINES; Monoclonal Antibodies; Anti Human Cytokine
 Applications Tested/Suitable for anti-Clu antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-Clu antibody    Clusterin antibody has been tested by ELISA, Western blot and immunohistochemistry analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot is 1:500 ~ 1:2,000 and immunohistochemistry analysis is 1:100~200. Recommended starting dilution for Western blot is 1:1,000 and Immunohistochemistry is 1:100.
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NCBI/Uniprot data below describe general gene information for Clu. It may not necessarily be applicable to this product.
 NCBI GI #    46048420
 NCBI GeneID    24854
 NCBI Accession #    NP_444180.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_053021.2 [Other Products]
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 UniProt Related Accession #    P05371 [Other Products]
 Molecular Weight    51,375 Da [Similar Products]
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 NCBI Official Full Name    clusterin
 NCBI Official Synonym Full Names    clusterin
 NCBI Official Symbol    Clu [Similar Products]
 NCBI Official Synonym Symbols   
CLI; DAG; APOJ; SGP2; SP40; SGP-2; SP-40; Trpm2; Trpmb; TRPM-2; TRPM2B; RATTRPM2B
[Similar Products]
 NCBI Protein Information    clusterin; dimeric acid glycoprotein; sulfated glycoprotein 2; testosterone repressed prostate message 2; testosterone-repressed prostate message; testostrone-repressed prostate message 2
 UniProt Protein Name    Clusterin
 UniProt Synonym Protein Names   
Dimeric acid glycoprotein; DAG; Sulfated glycoprotein 2; SGP-2; Testosterone repressed prostate message 2; TRPM-2
 Protein Family    Clusterin
 UniProt Gene Name    Clu [Similar Products]
 UniProt Synonym Gene Names    DAG; SGP-2; TRPM-2 [Similar Products]
 UniProt Entry Name    CLUS_RAT
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 NCBI Summary for Clu    The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders.[provided by RefSeq, May 2011]
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 UniProt Comments for Clu    CLU: Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress- induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation. Belongs to the clusterin family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Apoptosis; Secreted; Secreted, signal peptide

Cellular Component: extracellular matrix; extracellular space; neuron projection; growth cone; mitochondrion; endoplasmic reticulum; perinuclear region of cytoplasm; mitochondrial membrane; cytoplasm; cytosol; nucleus

Molecular Function: protein binding; ubiquitin protein ligase binding; ATPase activity; protein N-terminus binding; misfolded protein binding

Biological Process: response to light stimulus; response to misfolded protein; positive regulation of nitric oxide biosynthetic process; protein stabilization; positive regulation of apoptosis; response to virus; cell morphogenesis; microglial cell activation; positive regulation of tumor necrosis factor production; endocrine pancreas development; negative regulation of protein homooligomerization; activation of NF-kappaB transcription factor; myelin maintenance in the central nervous system; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein import; positive regulation of cell proliferation; response to wounding; spermatogenesis; response to oxidative stress; positive regulation of cell differentiation; chaperone-mediated protein complex assembly; neurite morphogenesis; aging; negative regulation of apoptosis
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 Research Articles on Clu    1. Following restraint stress, hypothalamic and pituitary clusterin expression levels are augmented.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Clu antibodyDiseases associated with anti-Clu antibody
 Products by Pathway  Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >200 publications with Clu and Nervous System Diseases
 Brain Diseases Antibodies  >181 publications with Clu and Brain Diseases
 Alzheimer Disease Antibodies  >150 publications with Clu and Alzheimer Disease
 Prostatic Neoplasms Antibodies  >89 publications with Clu and Prostatic Neoplasms
 Kidney Diseases Antibodies  >62 publications with Clu and Kidney Diseases
 Cardiovascular Diseases Antibodies  >59 publications with Clu and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >55 publications with Clu and Disease Models, Animal
 Adenocarcinoma Antibodies  >51 publications with Clu and Adenocarcinoma
 Necrosis Antibodies  >51 publications with Clu and Necrosis
 Breast Neoplasms Antibodies  >48 publications with Clu and Breast Neoplasms
Organs/Tissues associated with anti-Clu antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >186 publications with Clu and Brain
 Prostate Antibodies  >131 publications with Clu and Prostate
 Kidney Antibodies  >89 publications with Clu and Kidney
 Liver Antibodies  >70 publications with Clu and Liver
 Eye Antibodies  >46 publications with Clu and Eye
 Testis Antibodies  >45 publications with Clu and Testis
 Lung Antibodies  >37 publications with Clu and Lung
 Artery Antibodies  >30 publications with Clu and Artery
 Heart Antibodies  >26 publications with Clu and Heart
 Ovary Antibodies  >11 publications with Clu and Ovary
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