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anti-C3 antibody :: Mouse Complement C3, C3a Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS632895 anti-C3 antibody
Unit / Price
0.05 mg  /  $890 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Complement C3, C3a, Monoclonal Antibody

 Also Known As   

Complement C3, C3a (Complement C3 alpha Chain, Complement Component C3a, C3/C3a, C3a Anaphylatoxin, Acylation Stimulating Protein, ASP, Complement Component 3, Complement Factor 3)

 Product Synonym Names    Anti -Complement C3, C3a (Complement C3 alpha Chain, Complement Component C3a, C3/C3a, C3a Anaphylatoxin, Acylation Stimulating Protein, ASP, Complement Component 3, Complement Factor 3)
 Product Gene Name   

anti-C3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (6677846..6720662, complement). Location: 19p13.3-p13.2
 OMIM    120700
 3D Structure    ModBase 3D Structure for P01024
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    10B377
 Host    Mouse
 Species Reactivity    Guinea Pig, Human, Rabbit
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 Specificity    Recognizes a C3a determinant which is present also on native C3. Allows discrimination of ubiquitous or nonspecifically bound native C3 from biologically active C3b fragment, C3b or C are negative with H13. Reported to block C3a functional activity.
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a lyophilized powder from PBS, 0.5% BSA, 0.09% sodium azide. Reconstitute with 1ml sterile ddH2O.
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 Immunogen    Human complement component C3
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-C3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-C3 antibody

   C3a is an anaphylatoxin derived from proteolytic degradation of complement C3 that increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
 Product Categories/Family for anti-C3 antibody    Antibodies; Abs to Complement
 Applications Tested/Suitable for anti-C3 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-C3 antibody    Suitable for use in ELISA, Immunohistochemistry and Western Blot.
Dilution: Immunohistochemistry (Frozen): 1:10
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NCBI/Uniprot data below describe general gene information for C3. It may not necessarily be applicable to this product.
 NCBI GI #    115298678
 NCBI GeneID    718
 NCBI Accession #    NP_000055.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000064.2 [Other Products]
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 UniProt Primary Accession #    P01024 [Other Products]
 UniProt Secondary Accession #    A7E236 [Other Products]
 UniProt Related Accession #    P01024; Q6LDJ0 [Other Products]
 Molecular Weight    187,148 Da [Similar Products]
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 NCBI Official Full Name    complement C3
 NCBI Official Synonym Full Names    complement component 3
 NCBI Official Symbol    C3 [Similar Products]
 NCBI Official Synonym Symbols   
ASP; AHUS5; ARMD9; CPAMD1
[Similar Products]
 NCBI Protein Information    complement C3; OTTHUMP00000197086; complement component C3; acylation-stimulating protein cleavage product; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
 UniProt Protein Name    Complement C3
 UniProt Synonym Protein Names   
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
 Protein Family    Complement C3
 UniProt Gene Name    C3 [Similar Products]
 UniProt Synonym Gene Names    CPAMD1 [Similar Products]
 UniProt Entry Name    CO3_HUMAN
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 NCBI Summary for C3    Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection. [provided by RefSeq]
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 UniProt Comments for C3    C3: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Defects in C3 are the cause of complement component 3 deficiency (C3D). A rare defect of the complement classical pathway. Patients develop recurrent, severe, pyogenic infections because of ineffective opsonization of pathogens. Some patients may also develop autoimmune disorders, such as arthralgia and vasculitic rashes, lupus-like syndrome and membranoproliferative glomerulonephritis. Genetic variation in C3 is associated with susceptibility to age-related macular degeneration type 9 (ARMD9). ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin- containing structure known as Bruch membrane. Defects in C3 are a cause of susceptibility to hemolytic uremic syndrome atypical type 5 (AHUS5). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Increased levels of C3 and its cleavage product ASP, are associated with obesity, diabetes and coronary heart disease. Short-term endurance training reduces baseline ASP levels and subsequently fat storage.

Protein type: Secreted; Secreted, signal peptide; Inhibitor

Chromosomal Location of Human Ortholog: 19p13.3-p13.2

Cellular Component: extracellular space; extracellular region; plasma membrane

Molecular Function: protein binding; endopeptidase inhibitor activity; C5L2 anaphylatoxin chemotactic receptor binding; receptor binding

Biological Process: regulation of immune response; complement activation, alternative pathway; fatty acid metabolic process; signal transduction; complement activation; G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; positive regulation of activation of membrane attack complex; positive regulation of type IIa hypersensitivity; positive regulation of G-protein coupled receptor protein signaling pathway; regulation of complement activation; innate immune response; immune response; positive regulation of protein amino acid phosphorylation; inflammatory response; complement activation, classical pathway

Disease: Complement Component 3 Deficiency, Autosomal Recessive; Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 5; Macular Degeneration, Age-related, 9
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 Research Articles on C3    1. Complement 3 and factor h in human cerebrospinal fluid have roles in Parkinson's disease, Alzheimer's disease, and multiple-system atrophy
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-C3 antibodyPathways associated with anti-C3 antibody
 Reference Product  PubMed Publications
 CR1 antibody  >401 publications with C3 and CR1
 CR2 antibody  >278 publications with C3 and CR2
 CD46 antibody  >170 publications with C3 and CD46
 CFH antibody  >141 publications with C3 and CFH
 ITGAM antibody  >67 publications with C3 and ITGAM
 CFI antibody  >58 publications with C3 and CFI
 CFB antibody  >57 publications with C3 and CFB
 CFHR3 antibody  >21 publications with C3 and CFHR3
 ITGAX antibody  >17 publications with C3 and ITGAX
 MASP1 antibody  >15 publications with C3 and MASP1
 Products by Pathway  Pathway Diagram
 Activation Of C3 And C5 Pathway antibodies  Activation Of C3 And C5 Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 Alternative Complement Activation Pathway antibodies  Alternative Complement Activation Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
Diseases associated with anti-C3 antibodyOrgans/Tissues associated with anti-C3 antibody
 Disease Name  Pubmed Publications
 Autoimmune Diseases Antibodies  >3584 publications with C3 and Autoimmune Diseases
 Kidney Diseases Antibodies  >3249 publications with C3 and Kidney Diseases
 Neoplasms Antibodies  >2459 publications with C3 and Neoplasms
 Cardiovascular Diseases Antibodies  >2047 publications with C3 and Cardiovascular Diseases
 Inflammation Antibodies  >1563 publications with C3 and Inflammation
 Immune Complex Diseases Antibodies  >980 publications with C3 and Immune Complex Diseases
 Lung Diseases Antibodies  >907 publications with C3 and Lung Diseases
 Liver Diseases Antibodies  >838 publications with C3 and Liver Diseases
 Hemorrhage Antibodies  >679 publications with C3 and Hemorrhage
 Carcinoma Antibodies  >675 publications with C3 and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >10687 publications with C3 and Blood
 Kidney Antibodies  >3071 publications with C3 and Kidney
 Bone Antibodies  >2307 publications with C3 and Bone
 Skin Antibodies  >2079 publications with C3 and Skin
 Brain Antibodies  >1718 publications with C3 and Brain
 Liver Antibodies  >1568 publications with C3 and Liver
 Muscle Antibodies  >1457 publications with C3 and Muscle
 Spinal Cord Antibodies  >1265 publications with C3 and Spinal Cord
 Nerve Antibodies  >1113 publications with C3 and Nerve
 Lung Antibodies  >949 publications with C3 and Lung
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