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anti-C4B antibody :: Mouse Complement C4d Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS605576 anti-C4B antibody
Unit / Price
0.1 mg  /  $730 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Complement C4d (C4B), Monoclonal Antibody

 Also Known As   

Complement C4d (Gg)

 Product Synonym Names    Anti -Complement C4d (Gg)
 Product Gene Name   

anti-C4B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.11 (31982572..32003195). Location: 6p21.3
 OMIM    120790
 3D Structure    ModBase 3D Structure for P0C0L5
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    9G175
 Host    Mouse
 Species Reactivity    Guinea Pig, Human
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 Specificity    Recognizes an epitope on the alpha 2 chain of human C4d. It recognizes C4, C4b and C4d. Species crossreactivity: guinee pig
 Purity/Purification    Affinity Purified
Purified
 Form/Format    Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.
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 Immunogen    Human C4d.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-C4B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-C4B antibody

   Complement factor C4, formerly known as Gg protein, consists of an alpha-, beta-, and gamma-chain. The classical pathway of complement and the mannose binding lectin (MBL) activation pathway converge at C4. C1s, MASP-1 and MASP-2 cleave C4 resulting in the formation of C4a and C4b. The latter can be cleaved resulting in C4c and C4d, in which step all functional sites are lost. Therefore, the C4d activation fragment of C4 is an excellent marker for classical complement pathway and MBL pathway activation. In a number of diseases such as rheumatoid arthritis (RA), hereditary angioedema (HAE), systemic lupus erythematosus (SLE) and chronic urticaria with hypercomplementemia levels of C4d are significantly elevated in serum or plasma. C4d levels may also be elevated in plasma from patients with a variety of humoral autoimmune diseases in which complement activation is known to occur. Deposition of C4d in peritubular capillaries has been shown to be a sensitive marker for antibody-mediated (humoral) rejection in renal transplant biopsies.
 Product Categories/Family for anti-C4B antibody    Antibodies; Abs to Complement
 Applications Tested/Suitable for anti-C4B antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-C4B antibody    Suitable for use in Western Blot, Immunohistochemistry (frozen), and Immunoassays.
Dilution: Western Blot: 1:50
Immunohistochemistry (frozen): 1:50
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NCBI/Uniprot data below describe general gene information for C4B. It may not necessarily be applicable to this product.
 NCBI GI #    13936423
 NCBI GeneID    721
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 UniProt Primary Accession #    P0C0L5 [Other Products]
 UniProt Secondary Accession #    P01028; P78445; Q13160; Q13906; Q14033; Q14835; Q9NPK5; Q9UIP5 [Other Products]
 UniProt Related Accession #    P0C0L5; Q6U2E0; Q6U2E5; Q6U2F3; Q6U2F4; Q6U2F6; Q6U2G0; Q6U2G1; Q6U2H4; Q6U2I5 [Other Products]
 Molecular Weight    192,793 Da [Similar Products]
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 NCBI Official Full Name    C4 complement C4d region
 NCBI Official Synonym Full Names    complement component 4B (Chido blood group)
 NCBI Official Symbol    C4B [Similar Products]
 NCBI Official Synonym Symbols   
CH; C4F; CO4; C4B1; C4B2; C4B3; C4B5; C4B12; CPAMD3; FLJ60561; MGC164979
[Similar Products]
 NCBI Protein Information    complement C4-B; Chido form of C4; complement C4B1a; OTTHUMP00000029269; basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3
 UniProt Protein Name    Complement C4-B
 UniProt Synonym Protein Names   
Basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3
 Protein Family    Complement C4
 UniProt Gene Name    C4B [Similar Products]
 UniProt Synonym Gene Names    CO4; CPAMD3 [Similar Products]
 UniProt Entry Name    CO4B_HUMAN
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 NCBI Summary for C4B    This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. [provided by RefSeq]
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 UniProt Comments for C4B    C4B: C4 plays a central role in the activation of the classical pathway of the complement system. It is processed by activated C1 which removes from the alpha chain the C4a anaphylatoxin. The remaining alpha chain fragment C4b is the major activation product and is an essential subunit of the C3 convertase (C4b2a) and the C5 convertase (C3bC4b2a) enzymes of the classical complement pathway. Defects in C4B are a cause of susceptibility to systemic lupus erythematosus (SLE). A chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Interindividual copy- number variation (CNV) of complement component C4 and associated polymorphisms result in different susceptibilities to SLE. The risk of SLE susceptibility has been shown to be significantly increased among subjects with only two copies of total C4. A high copy number is a protective factor against SLE. Defects in C4B are the cause of complement component 4B deficiency (C4BD). A rare defect of the complement classical pathway associated with the development of autoimmune disorders, mainly systemic lupus with or without associated glomerulonephritis.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: extracellular space; extracellular region; plasma membrane

Molecular Function: complement binding; endopeptidase inhibitor activity; carbohydrate binding

Biological Process: detection of molecule of bacterial origin; regulation of complement activation; innate immune response; opsonization; inflammatory response; complement activation, classical pathway; complement activation

Disease: Complement Component 4b Deficiency
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 Research Articles on C4B    1. C4 mRNA levels of the two isoforms (C4A and C4B) were significantly reduced in hepatocytes transfected with RNA from HCV genotype 1a or 2a.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-C4B antibodyPathways associated with anti-C4B antibody
 Reference Product  PubMed Publications
 C4BPA antibody  >39 publications with C4B and C4BPA
 Products by Pathway  Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
 Systemic Lupus Erythematosus Pathway antibodies  Systemic Lupus Erythematosus Pathway Diagram
 Systemic Lupus Erythematosus Pathway antibodies  Systemic Lupus Erythematosus Pathway Diagram
Diseases associated with anti-C4B antibodyOrgans/Tissues associated with anti-C4B antibody
 Disease Name  Pubmed Publications
 Autoimmune Diseases Antibodies  >322 publications with C4B and Autoimmune Diseases
 Cardiovascular Diseases Antibodies  >187 publications with C4B and Cardiovascular Diseases
 Vascular Diseases Antibodies  >183 publications with C4B and Vascular Diseases
 Kidney Diseases Antibodies  >143 publications with C4B and Kidney Diseases
 Inflammation Antibodies  >140 publications with C4B and Inflammation
 Neoplasms Antibodies  >85 publications with C4B and Neoplasms
 Skin Diseases Antibodies  >81 publications with C4B and Skin Diseases
 Blood Coagulation Disorders Antibodies  >79 publications with C4B and Blood Coagulation Disorders
 Arthritis, Rheumatoid Antibodies  >69 publications with C4B and Arthritis, Rheumatoid
 Hyperplasia Antibodies  >57 publications with C4B and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1011 publications with C4B and Blood
 Kidney Antibodies  >295 publications with C4B and Kidney
 Liver Antibodies  >119 publications with C4B and Liver
 Heart Antibodies  >76 publications with C4B and Heart
 Muscle Antibodies  >42 publications with C4B and Muscle
 Lung Antibodies  >42 publications with C4B and Lung
 Skin Antibodies  >40 publications with C4B and Skin
 Brain Antibodies  >40 publications with C4B and Brain
 Ovary Antibodies  >16 publications with C4B and Ovary
 Intestine Antibodies  >15 publications with C4B and Intestine
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