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anti-C5 antibody :: Mouse anti-Human Complement C5, C5a Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS632288 anti-C5 antibody
Unit / Price
0.1 mg  /  $715 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Complement C5, C5a, Monoclonal Antibody

 Also Known As   

Complement C5, C5a

 Product Synonym Names    Anti -Complement C5, C5a
 Product Gene Name   

anti-C5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 9; NC_000009.11 (123714613..123812554, complement). Location: 9q33-q34
 OMIM    120900
 3D Structure    ModBase 3D Structure for P01031
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    6A532
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes the N-terminus of human C5. Reacts both with intact C5 (190kD) as with C5a (115kD).
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.1% BSA.
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 Immunogen    Human C5/C5a
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-C5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-C5 antibody

   C5 is involved in the activation of the lythic pathway within the complement system which is an important factor in innate immunity. The complement pathways can be divided in the activation pathways and lytic pathway. The activation pathways lead via C3 to the cleavage of the fifth complement component C5 into C5a and C5b. C5a induces smooth muscle contraction, increases vascular permeability, causes degranulation of mast cells and basophils, and release of lysosomal enzymes. In addition C5a stimulates the directed migration of neutrophils, eosinophils, basophils and monocytes. Recent studies indicate the modulation of the acute-phase response in liver and an overall immune response by inducing synthesis of cytokines such as TNF-alpha, IL-1beta, IL-6 and IL-8.
 Product Categories/Family for anti-C5 antibody    Antibodies; Abs to Complement
 Applications Tested/Suitable for anti-C5 antibody   

ELISA (EL/EIA), Neutralization

 Application Notes for anti-C5 antibody    Suitable for use in ELISA and Neutralization.
Dilution: Neutralization of Biological Activity: In vitro dilutions have to be made according to the amounts of C5/C5a to be inactivated
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NCBI/Uniprot data below describe general gene information for C5. It may not necessarily be applicable to this product.
 NCBI GI #    38016947
 NCBI GeneID    727
 NCBI Accession #    NP_001726.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001735.2 [Other Products]
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 UniProt Primary Accession #    P01031 [Other Products]
 UniProt Secondary Accession #    Q14CJ0; Q27I61 [Other Products]
 UniProt Related Accession #    P01031; Q59GS8 [Other Products]
 Molecular Weight    188,305 Da [Similar Products]
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 NCBI Official Full Name    complement C5 preproprotein
 NCBI Official Synonym Full Names    complement component 5
 NCBI Official Symbol    C5 [Similar Products]
 NCBI Official Synonym Symbols   
CPAMD4; FLJ17816; FLJ17822; MGC142298
[Similar Products]
 NCBI Protein Information    complement C5; OTTHUMP00000022001; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
 UniProt Protein Name    Complement C5
 UniProt Synonym Protein Names   
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
 Protein Family    Complement C5
 UniProt Gene Name    C5 [Similar Products]
 UniProt Synonym Gene Names    CPAMD4 [Similar Products]
 UniProt Entry Name    CO5_HUMAN
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 NCBI Summary for C5    The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq]
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 UniProt Comments for C5    C5: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Defects in C5 are the cause of complement component 5 deficiency (C5D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9q33-q34

Cellular Component: membrane attack complex; extracellular space; extracellular region

Molecular Function: protein binding; chemokine activity; endopeptidase inhibitor activity; receptor binding; C5a anaphylatoxin chemotactic receptor binding

Biological Process: positive regulation of chemotaxis; in utero embryonic development; activation of MAPK activity; cytolysis; complement activation, alternative pathway; chemotaxis; glucose homeostasis; leukocyte migration during inflammatory response; complement activation; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; cell surface receptor linked signal transduction; regulation of complement activation; innate immune response; response to stress; negative regulation of dopamine secretion; inflammatory response; complement activation, classical pathway

Disease: Complement Component 5 Deficiency; Eculizumab, Poor Response To
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 Research Articles on C5    1. Data show that the colocalization of C5a, MMP-1, and MMP-9 in coronary plaques.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-C5 antibodyPathways associated with anti-C5 antibody
 Reference Product  PubMed Publications
 C5AR1 antibody  >4 publications with C5 and C5AR1
 C8B antibody  >3 publications with C5 and C8B
 Products by Pathway  Pathway Diagram
 Activation Of C3 And C5 Pathway antibodies  Activation Of C3 And C5 Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with anti-C5 antibodyOrgans/Tissues associated with anti-C5 antibody
 Disease Name  Pubmed Publications
 Neurologic Manifestations Antibodies  >763 publications with C5 and Neurologic Manifestations
 Inflammation Antibodies  >578 publications with C5 and Inflammation
 Kidney Diseases Antibodies  >320 publications with C5 and Kidney Diseases
 Necrosis Antibodies  >185 publications with C5 and Necrosis
 Carcinoma Antibodies  >180 publications with C5 and Carcinoma
 Anemia Antibodies  >129 publications with C5 and Anemia
 Drug Toxicity Antibodies  >128 publications with C5 and Drug Toxicity
 Edema Antibodies  >126 publications with C5 and Edema
 Congenital Abnormalities Antibodies  >126 publications with C5 and Congenital Abnormalities
 Hemorrhage Antibodies  >124 publications with C5 and Hemorrhage
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1605 publications with C5 and Bone
 Muscle Antibodies  >1017 publications with C5 and Muscle
 Brain Antibodies  >577 publications with C5 and Brain
 Lung Antibodies  >409 publications with C5 and Lung
 Liver Antibodies  >384 publications with C5 and Liver
 Kidney Antibodies  >370 publications with C5 and Kidney
 Spleen Antibodies  >159 publications with C5 and Spleen
 Intestine Antibodies  >105 publications with C5 and Intestine
 Bone Marrow Antibodies  >100 publications with C5 and Bone Marrow
 Eye Antibodies  >78 publications with C5 and Eye
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