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anti-C5 antibody :: Mouse Complement C5 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS530540 anti-C5 antibody
Unit / Price
0.05 mg  /  $430 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Complement C5, Monoclonal Antibody

 Also Known As   

Complement C5 antibody

 Product Synonym Names    Monoclonal Complement C5; Anti-Complement C5; Complement C5; Complement C -5; Complement C 5; C5
 Product Gene Name   

anti-C5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    120900
 3D Structure    ModBase 3D Structure for P01031
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    HCC5.1
 Host    Mouse
 Species Reactivity    Human complement C5
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 Purity/Purification    Protein A affinity chromatography
 Form/Format    Lyophilized from a solution containing 0.5% BSA and 0.09% NaN3.
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 Biological Significance    Complement component 5 is a protein involved in the complement system. It is cleaved into C5a and C5b, C5a plays an important role in chemotaxis, C5b forms the first part of the complement membrane attack complex. Deficiency is thought to cause Leiner's disease.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Immunogen    Complement C5 antibody was raised in mouse using human complement component C5 as the immunogen.
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 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-C5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-C5 antibody

   Mouse monoclonal Complement C5 antibody
 Product Categories/Family for anti-C5 antibody    Immunology
 Applications Tested/Suitable for anti-C5 antibody   

ELISA (EIA), Immunohistochemistry (IHC) Formalin

 Application Notes for anti-C5 antibody    IHC-F: 1:10
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NCBI/Uniprot data below describe general gene information for C5. It may not necessarily be applicable to this product.
 NCBI GI #    38016947
 NCBI GeneID    727
 NCBI Accession #    NP_001726.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001735.2 [Other Products]
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 UniProt Primary Accession #    P01031 [Other Products]
 UniProt Secondary Accession #    Q14CJ0; Q27I61 [Other Products]
 UniProt Related Accession #    P01031 [Other Products]
 Molecular Weight    188,305 Da [Similar Products]
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 NCBI Official Full Name    complement C5 preproprotein
 NCBI Official Synonym Full Names    complement component 5
 NCBI Official Symbol    C5 [Similar Products]
 NCBI Official Synonym Symbols   
C5D; C5a; C5b; ECLZB; CPAMD4
[Similar Products]
 NCBI Protein Information    complement C5
 UniProt Protein Name    Complement C5
 UniProt Synonym Protein Names   
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
 Protein Family    Complement C5
 UniProt Gene Name    C5 [Similar Products]
 UniProt Synonym Gene Names    CPAMD4 [Similar Products]
 UniProt Entry Name    CO5_HUMAN
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 NCBI Summary for C5    The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for C5    C5: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Defects in C5 are the cause of complement component 5 deficiency (C5D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9q33-q34

Cellular Component: membrane attack complex; extracellular space; extracellular region

Molecular Function: protein binding; chemokine activity; endopeptidase inhibitor activity; receptor binding; C5a anaphylatoxin chemotactic receptor binding

Biological Process: in utero embryonic development; positive regulation of chemotaxis; activation of MAPK activity; cytolysis; complement activation, alternative pathway; chemotaxis; glucose homeostasis; leukocyte migration during inflammatory response; complement activation; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; cell surface receptor linked signal transduction; regulation of complement activation; innate immune response; response to stress; negative regulation of dopamine secretion; inflammatory response; complement activation, classical pathway

Disease: Complement Component 5 Deficiency; Eculizumab, Poor Response To
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 Research Articles on C5    1. In conclusion, the present study indicates that C5a may promote the proliferation of breast cancer cells through Akt1 activation of the RGC-32 gene.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-C5 antibodyPathways associated with anti-C5 antibody
 Reference Product  PubMed Publications
 C5AR1 antibody  >16 publications with C5 and C5AR1
 C8A antibody  >5 publications with C5 and C8A
 GPR77 antibody  >5 publications with C5 and GPR77
 C8B antibody  >3 publications with C5 and C8B
 CXCR7 antibody  >1 publications with C5 and CXCR7
 BDKRB2 antibody  >1 publications with C5 and BDKRB2
 C3AR1 antibody  >1 publications with C5 and C3AR1
 Products by Pathway  Pathway Diagram
 Activation Of C3 And C5 Pathway antibodies  Activation Of C3 And C5 Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
Diseases associated with anti-C5 antibodyOrgans/Tissues associated with anti-C5 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2282 publications with C5 and Nervous System Diseases
 Neurologic Manifestations Antibodies  >936 publications with C5 and Neurologic Manifestations
 Inflammation Antibodies  >727 publications with C5 and Inflammation
 Cardiovascular Diseases Antibodies  >667 publications with C5 and Cardiovascular Diseases
 Death Antibodies  >502 publications with C5 and Death
 Kidney Diseases Antibodies  >438 publications with C5 and Kidney Diseases
 Lung Diseases Antibodies  >327 publications with C5 and Lung Diseases
 Anemia Antibodies  >245 publications with C5 and Anemia
 Necrosis Antibodies  >226 publications with C5 and Necrosis
 Heart Diseases Antibodies  >173 publications with C5 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2204 publications with C5 and Bone
 Muscle Antibodies  >1247 publications with C5 and Muscle
 Brain Antibodies  >755 publications with C5 and Brain
 Kidney Antibodies  >485 publications with C5 and Kidney
 Lung Antibodies  >475 publications with C5 and Lung
 Liver Antibodies  >449 publications with C5 and Liver
 Spleen Antibodies  >170 publications with C5 and Spleen
 Bone Marrow Antibodies  >128 publications with C5 and Bone Marrow
 Intestine Antibodies  >121 publications with C5 and Intestine
 Eye Antibodies  >105 publications with C5 and Eye
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