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anti-C5AR2 antibody :: Mouse anti-Human Complement C5a des-Arg Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS601718 anti-C5AR2 antibody
Unit / Price
0.1 mg  /  $715 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Complement C5a des-Arg (C5AR2), Monoclonal Antibody

 Also Known As   

Complement C5a des-Arg (Neo-Epitope)

 Product Synonym Names    Anti -Complement C5a des-Arg (Neo-Epitope)
 Product Gene Name   

anti-C5AR2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (47835404..47845272). Location: 19q13.33
 OMIM    609949
 3D Structure    ModBase 3D Structure for Q9P296
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    6A535
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes a neo-epitope on human Complement C5a (des-Arg) that is formed upon cleavage of C5 into C5a and C5b.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.1% BSA.
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 Immunogen    Human C5a (aa65-73, ISHKDMQLG)
 Positive Control    Human granulocytes
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
 Other Notes    Small volumes of anti-C5AR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-C5AR2 antibody

   C5 is involved in the activation of the lytic pathway within the complement system which is an important factor in innate immunity. The complement pathways can be divided into the activation pathways and lytic pathway. The activation pathways lead, via C3, to the cleavage of the fifth complement component C5. C5a induces smooth muscle contraction, increases vascular permeability, causes degranulation of mast cells and basophils, and release of lysosomal enzymes. In addition C5a stimulates the directed migration of neutrophils, eosinophils, basophils and monocytes. Recent studies indicate the modulation of the acute-phase response in liver and an overall immune response by inducing synthesis of cytokines such as TNF-alpha IL-1beta, IL-6 and IL-8.
 Product Categories/Family for anti-C5AR2 antibody    Antibodies; Abs to Complement
 Applications Tested/Suitable for anti-C5AR2 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Neutralization

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NCBI/Uniprot data below describe general gene information for C5AR2. It may not necessarily be applicable to this product.
 NCBI GI #    415712997
 NCBI GeneID    27202
 NCBI Accession #    NP_001258679.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001271750.1 [Other Products]
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 UniProt Primary Accession #    Q9P296 [Other Products]
 UniProt Secondary Accession #    B2RA09 [Other Products]
 UniProt Related Accession #    Q9P296 [Other Products]
 Molecular Weight    36,080 Da [Similar Products]
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 NCBI Official Full Name    C5a anaphylatoxin chemotactic receptor 2
 NCBI Official Synonym Full Names    complement component 5a receptor 2
 NCBI Official Symbol    C5AR2 [Similar Products]
 NCBI Official Synonym Symbols   
C5L2; GPF77; GPR77
[Similar Products]
 NCBI Protein Information    C5a anaphylatoxin chemotactic receptor 2; G protein-coupled receptor 77; G protein-coupled receptor C5L2; C5a anaphylatoxin chemotactic receptor C5L2
 UniProt Protein Name    C5a anaphylatoxin chemotactic receptor 2
 UniProt Synonym Protein Names   
Complement component 5a receptor 2; G-protein coupled receptor 77
 Protein Family    C5a anaphylatoxin chemotactic receptor
 UniProt Gene Name    C5AR2 [Similar Products]
 UniProt Synonym Gene Names    C5L2; GPR77 [Similar Products]
 UniProt Entry Name    C5AR2_HUMAN
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 NCBI Summary for C5AR2    This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
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 UniProt Comments for C5AR2    C5AR2: Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: apical part of cell; integral to membrane; basal plasma membrane; plasma membrane

Molecular Function: protein binding; C5a anaphylatoxin receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of tumor necrosis factor production; chemotaxis; inflammatory response; positive regulation of epithelial cell proliferation
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 Research Articles on C5AR2    1. The results suggest that insulin sensitivity may be permissive for coupling of C5L2 levels to lipid storage and utilization.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-C5AR2 antibody
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
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