AAA91279.1
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,205 Da
NCBI Official Full Name
connective tissue growth factor
NCBI Official Synonym Full Names
connective tissue growth factor
NCBI Protein Information
connective tissue growth factor
UniProt Protein Name
Connective tissue growth factor
UniProt Synonym Protein Names
CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8; IBP-8; IGF-binding protein 8; IGFBP-8
UniProt Synonym Gene Names
NCBI Summary for CTGF
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]
UniProt Comments for CTGF
CTGF: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Belongs to the CCN family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6q23.2
Cellular Component: extracellular region; Golgi apparatus; intracellular membrane-bound organelle; plasma membrane
Molecular Function: heparin binding; integrin binding; protein binding; protein C-terminus binding
Biological Process: cell adhesion; cell-cell signaling; epidermis development; positive regulation of cell differentiation; positive regulation of JNK cascade; positive regulation of stress fiber formation; response to wounding; transcription initiation from RNA polymerase II promoter
Research Articles on CTGF
Precautions
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Products associated with anti-CTGF antibody
Pathways associated with anti-CTGF antibody
Diseases associated with anti-CTGF antibody
Organs/Tissues associated with anti-CTGF antibody
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