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anti-CNTNAP1 antibody :: Mouse anti-Rat Contactin-associated protein 1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS609200 anti-CNTNAP1 antibody
Unit / Price
0.1 mg  /  $655 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Contactin-associated protein 1 (CNTNAP1), Monoclonal Antibody

 Also Known As   

Contactin-associated protein 1 (Caspr1)

 Product Synonym Names    Anti -Contactin-associated protein 1 (Caspr1)
 Product Gene Name   

anti-CNTNAP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (40834632..40852011). Location: 17q21
 OMIM    602346
 3D Structure    ModBase 3D Structure for P78357
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 Clonality    Monoclonal
 Isotype    IgG1k
 Clone Number    11C235
 Host    Mouse
 Species Reactivity    Rat
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 Specificity    Recognizes rat Caspr. Species sequence homology: mouse 100%.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
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 Immunogen    Recombinant protein corresponding to rat Caspr.
 Positive Control    Rat brain membrane tissue lysate
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-CNTNAP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CNTNAP1 antibody

   Contactin-associated protein 1(Caspr) is a single-pass type I membrane protein belonging to the neurexin family and is comprised of one F5/8 type C domain, one fibrinogen C-terminal domain, two EGF-like domains, and four laminin G-like domains. Caspr is well documented for its interaction with contactin, an interaction that is crucial to the transport of Caspr to the plasma membrane, the mylination of glial cells, and the generation of axoglial junctions. Studies also suggest that Caspr may play a regulatory role in the cell surface expression of contactin and its targeting to different axonal domains. Expression of Caspr is largely observed in the brain, mainly in CNS myelinated nerve fibers within paranodal axoglial junctions.
 Product Categories/Family for anti-CNTNAP1 antibody    Antibodies; Abs to Neuroscience
 Applications Tested/Suitable for anti-CNTNAP1 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CNTNAP1 antibody    Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Immunohistochemistry: 1:300 detects Caspr in rat cerebellum and rat hippocampus tissues.
Western Blot: 0.5ug/ml detected Caspr on 10ug of rat brain membrane tissue lysate.
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NCBI/Uniprot data below describe general gene information for CNTNAP1. It may not necessarily be applicable to this product.
 NCBI GI #    4505463
 NCBI GeneID    8506
 NCBI Accession #    NP_003623.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003632.2 [Other Products]
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 UniProt Primary Accession #    P78357 [Other Products]
 UniProt Related Accession #    P78357 [Other Products]
 Molecular Weight    156,267 Da [Similar Products]
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 NCBI Official Full Name    contactin-associated protein 1
 NCBI Official Synonym Full Names    contactin associated protein 1
 NCBI Official Symbol    CNTNAP1 [Similar Products]
 NCBI Official Synonym Symbols   
P190; CASPR; NRXN4; CNTNAP
[Similar Products]
 NCBI Protein Information    contactin-associated protein 1; caspr1; neurexin 4; neurexin-4; neurexin IV
 UniProt Protein Name    Contactin-associated protein 1
 UniProt Synonym Protein Names   
Neurexin IV; Neurexin-4; p190
 Protein Family    Contactin-associated protein
 UniProt Gene Name    CNTNAP1 [Similar Products]
 UniProt Synonym Gene Names    CASPR; NRXN4 [Similar Products]
 UniProt Entry Name    CNTP1_HUMAN
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 NCBI Summary for CNTNAP1    The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. [provided by RefSeq]
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 UniProt Comments for CNTNAP1    CNTNAP1: Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells. Belongs to the neurexin family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: voltage-gated potassium channel complex; integral to plasma membrane; paranode region of axon; integral to membrane

Molecular Function: protein binding; SH3/SH2 adaptor activity; receptor activity; SH3 domain binding

Biological Process: neuromuscular process controlling posture; axon guidance; positive regulation of signal transduction; action potential propagation; axon cargo transport; cytoskeleton organization and biogenesis; neuromuscular process controlling balance; signal transduction; cell adhesion; neurite morphogenesis; paranodal junction assembly

Disease: Lethal Congenital Contracture Syndrome 7
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 Research Articles on CNTNAP1    1. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CNTNAP1 antibodyPathways associated with anti-CNTNAP1 antibody
 Reference Product  PubMed Publications
 NFASC antibody  >8 publications with CNTNAP1 and NFASC
 SRC antibody  >1 publications with CNTNAP1 and SRC
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 L1CAM Interactions Pathway antibodies  L1CAM Interactions Pathway Diagram
 Neurofascin Interactions Pathway antibodies  Neurofascin Interactions Pathway Diagram
Diseases associated with anti-CNTNAP1 antibodyOrgans/Tissues associated with anti-CNTNAP1 antibody
 Disease Name  Pubmed Publications
 Brain Neoplasms Antibodies  >1 publications with CNTNAP1 and Brain Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >40 publications with CNTNAP1 and Nerve
 Brain Antibodies  >23 publications with CNTNAP1 and Brain
 Eye Antibodies  >6 publications with CNTNAP1 and Eye
 Liver Antibodies  >1 publications with CNTNAP1 and Liver
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