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anti-BMPER antibody :: Rat anti-Human Crossveinless 2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS601225 anti-BMPER antibody
Unit / Price
0.1 mg  /  $630 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Crossveinless 2 (BMPER), Monoclonal Antibody

 Also Known As   

Crossveinless 2 (CV2, CV-2, CRIM3, BMP-Binding Endothelial Regulator Protein Precursor, BMPER2)

 Product Synonym Names    Anti -Crossveinless 2 (CV2, CV-2, CRIM3, BMP-Binding Endothelial Regulator Protein Precursor, BMPER2)
 Product Gene Name   

anti-BMPER antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    chromosome: 7; Location: 7p14.3
 OMIM    608699
 3D Structure    ModBase 3D Structure for Q8N8U9
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    7H123
 Host    Rat
 Species Reactivity    Human
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 Specificity    Recognizes human Crossveinless-2.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute with 1ml sterile, ddH2O or sterile 40-50% glycerol.
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 Immunogen    NS0-derived recombinant human CV-2 (aa34-685) Accession # NP_597725
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 Preparation and Storage    Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-BMPER antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BMPER antibody

   Crossveinless-2 (CV-2), also known as BMPER2 (BMP-binding endothelial regulator), is a secreted glycoprotein that contains a trypsin-inhibitory like domain, five cysteine-rich domains, and a von Willebrand factor type D domain. CV-2 modulates the activity of BMP-2 and BMP-4 in neural crest migration and osteoblast and chondrocyte differentiation. During zebrafish gastrulation, CV-2 is proteolytically cleaved to generate a BMP agonist from a BMP antagonist. Mature human and mouse CV-2 share 93% aa sequence identity.
 Product Categories/Family for anti-BMPER antibody    Antibodies; Abs to Proteins
 Applications Tested/Suitable for anti-BMPER antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-BMPER antibody    Suitable for use in Western Blot and ELISA.
Dilution: Western Blot: 1-2ug/ml
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NCBI/Uniprot data below describe general gene information for BMPER. It may not necessarily be applicable to this product.
 NCBI GI #    32892146
 NCBI GeneID    168667
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 UniProt Primary Accession #    Q8N8U9 [Other Products]
 UniProt Secondary Accession #    Q8TF36; A8K1P8 [Other Products]
 UniProt Related Accession #    Q8N8U9 [Other Products]
 Molecular Weight    75,997 Da [Similar Products]
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 NCBI Official Full Name    crossveinless-2
 NCBI Official Synonym Full Names    BMP binding endothelial regulator
 NCBI Official Symbol    BMPER [Similar Products]
 NCBI Official Synonym Symbols   
CV2; CV-2; CRIM3; BMPER
[Similar Products]
 NCBI Protein Information    BMP-binding endothelial regulator protein; hCV2; crossveinless 2; crossveinless-2; OTTHUMP00000158859; protein crossveinless-2; BMP-binding endothelial regulator precursor protein; bone morphogenetic protein-binding endothelial cell precursor-derived regulator
 UniProt Protein Name    BMP-binding endothelial regulator protein
 UniProt Synonym Protein Names   
Bone morphogenetic protein-binding endothelial cell precursor-derived regulator; Protein crossveinless-2
 Protein Family    BMP-binding endothelial regulator protein
 UniProt Gene Name    BMPER [Similar Products]
 UniProt Synonym Gene Names    KIAA1965 [Similar Products]
 UniProt Entry Name    BMPER_HUMAN
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 NCBI Summary for BMPER    This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis. [provided by RefSeq, Dec 2011]
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 UniProt Comments for BMPER    BMPER: Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes. Defects in BMPER are the cause of diaphanospondylodysostosis (DSD). A rare, recessively inherited, perinatal lethal skeletal disorder. The primary skeletal characteristics of the phenotype include a small chest, abnormal vertebral segmentation, and posterior rib gaps containing incompletely differentiated mesenchymal tissue. Consistent craniofacial features include ocular hypertelorism, epicanthal folds, a depressed nasal bridge with a short nose, and low-set ears. The most commonly described extraskeletal finding is nephroblastomatosis with cystic kidneys, but other visceral findings have been described in some cases.

Protein type: Secreted, signal peptide; Inhibitor; Secreted

Chromosomal Location of Human Ortholog: 7p14.3

Cellular Component: extracellular space

Biological Process: endothelial cell differentiation; blood vessel endothelial cell proliferation during sprouting angiogenesis; ureteric bud development; inner ear development; negative regulation of BMP signaling pathway; endothelial cell activation

Disease: Diaphanospondylodysostosis
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 Research Articles on BMPER    1. BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis.
2. Crossveinless-2 is an inhibitor of BMP function
3. BMPER is a novel BMP-binding protein that is expressed by endothelial cell precursors, has BMP-antagonizing activity, and may play a role in endothelial cell differentiation by modulating local BMP activity
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BMPER antibodyDiseases associated with anti-BMPER antibody
 Reference Product  PubMed Publications
 BMP4 antibody  >6 publications with BMPER and BMP4
 BMP2 antibody  >4 publications with BMPER and BMP2
 BMP6 antibody  >2 publications with BMPER and BMP6
 Disease Name  Pubmed Publications
 Neurodegenerative Diseases Antibodies  >3 publications with BMPER and Neurodegenerative Diseases
 Neoplasms Antibodies  >3 publications with BMPER and Neoplasms
 Congenital Abnormalities Antibodies  >2 publications with BMPER and Congenital Abnormalities
 Myocardial Infarction Antibodies  >1 publications with BMPER and Myocardial Infarction
 Craniofacial Abnormalities Antibodies  >1 publications with BMPER and Craniofacial Abnormalities
 Bone Diseases, Developmental Antibodies  >1 publications with BMPER and Bone Diseases, Developmental
 Limb Deformities, Congenital Antibodies  >1 publications with BMPER and Limb Deformities, Congenital
 Necrosis Antibodies  >1 publications with BMPER and Necrosis
 Inflammation Antibodies  >1 publications with BMPER and Inflammation
 Heart Defects, Congenital Antibodies  >1 publications with BMPER and Heart Defects, Congenital
Organs/Tissues associated with anti-BMPER antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >15 publications with BMPER and Bone
 Blood Antibodies  >7 publications with BMPER and Blood
 Vascular Antibodies  >7 publications with BMPER and Vascular
 Embryonic Tissue Antibodies  >2 publications with BMPER and Embryonic Tissue
 Lung Antibodies  >1 publications with BMPER and Lung
 Testis Antibodies  >1 publications with BMPER and Testis
 Connective Tissue Antibodies  >1 publications with BMPER and Connective Tissue
 Skin Antibodies  >1 publications with BMPER and Skin
 Kidney Antibodies  >1 publications with BMPER and Kidney
 Ovary Antibodies  >1 publications with BMPER and Ovary
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