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anti-PPIB antibody :: Mouse anti-Human Cyclophilin B Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS200088
Western Blot (WB)
Unit / Price
0.05 mL  /  $240 +1 FREE 8GB USB
0.1 mL  /  $315 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cyclophilin B (PPIB), Monoclonal Antibody

 Also Known As   

Cyclophilin B antibody (clone k2E2)

 Product Synonym Names    PPIB; Peptidylprolyl isomerase B; CYPB; SCYLP; CYP-S1: Cyclophilin-B; Cyclophilin B; 26- 216aa; AA553318; AI844835; Cphn 2; Cphn2; CyP 20b; AA408962; CYP S1; MGC14109; MGC2224; peptidyl prolyl cis trans isomerase B; Peptidyl prolyl cis trans isomerase B precursor; PPIase; Rotamase; S cyclophilin.
 Product Gene Name   

anti-PPIB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Monoclonal
 Isotype    IgG1, k
 Clone Number    k2E2
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    By protein-G affinity chromatography
 Form/Format    Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.
 Concentration    1mg/ml (lot specific)
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 Antigen Species    Human
 Clone    Anti-human Cyclophilin B mAb, clone k2E2, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human Cyclophilin B protein.
 Immunogen    Recombinant human Cyclophilin B (26-216aa) purified from E Coli
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 Preparation and Storage    Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of anti-PPIB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PPIB antibody

   Cyclophilin B (also known as PPIB, peptidylpropyl isomerase B) is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Cyclophilin B is necessary for the prolactin-induced proliferation, cell growth, and the nuclear retrotransport of prolactin.
 Product Categories/Family for anti-PPIB antibody    Signal Transduction
 Applications Tested/Suitable for anti-PPIB antibody   

ELISA (EIA), Western Blot (WB) (Cell lysate)

 Application Notes for anti-PPIB antibody    The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1,000 ~ 2,000. Recommended starting dilution is 1:1,000.
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 Western Blot (WB) of anti-PPIB antibody    Cell lysates of HepG2(30ug) and HeLa(30ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human Cyclophilin B (1:1,000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
anti-PPIB antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PPIB. It may not necessarily be applicable to this product.
 NCBI GI #    4758950
 NCBI GeneID    5479
 NCBI Accession #    NP_000933 [Other Products]
 NCBI GenBank Nucleotide #    NM_000942.4 [Other Products]
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 UniProt Secondary Accession #    Q6IBH5; Q9BVK5; A8K534 [Other Products]
 UniProt Related Accession #    P23284 [Other Products]
 Molecular Weight    23,743 Da [Similar Products]
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 NCBI Official Full Name    peptidyl-prolyl cis-trans isomerase B
 NCBI Official Synonym Full Names    peptidylprolyl isomerase B (cyclophilin B)
 NCBI Official Symbol    PPIB [Similar Products]
 NCBI Official Synonym Symbols   
OI9; CYPB; SCYLP; CYP-S1; HEL-S-39
[Similar Products]
 NCBI Protein Information    peptidyl-prolyl cis-trans isomerase B; PPIase B; S-cyclophilin; cyclophilin-like protein; epididymis secretory protein Li 39; rotamase B
 UniProt Protein Name    Peptidyl-prolyl cis-trans isomerase B
 UniProt Synonym Protein Names   
CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP
 Protein Family    Probable peptidyl-prolyl cis-trans isomerase
 UniProt Gene Name    PPIB [Similar Products]
 UniProt Synonym Gene Names    CYPB; PPIase B; SCYLP [Similar Products]
 UniProt Entry Name    PPIB_HUMAN
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 NCBI Summary for PPIB    The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]
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 UniProt Comments for PPIB    PPIB: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9). OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients. Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.

Protein type: RNA-binding; Secreted; Isomerase; Chaperone; Cyclophilin; EC 5.2.1.8; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15q21-q22

Cellular Component: smooth endoplasmic reticulum; focal adhesion; membrane; endoplasmic reticulum; perinuclear region of cytoplasm; endoplasmic reticulum lumen; melanosome; nucleus

Molecular Function: collagen binding; protein binding; peptidyl-prolyl cis-trans isomerase activity; unfolded protein binding; protein complex binding; peptide binding

Biological Process: extracellular matrix organization and biogenesis; protein peptidyl-prolyl isomerization; protein stabilization; positive regulation of multicellular organism growth

Disease: Osteogenesis Imperfecta, Type Ix
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Product References and Citations for anti-PPIB antibody

   Watashi k, et al., (2005) Mol Cell 19(1):111-112 Yurchenko V, et al., (2001) Biochem Biophys Res Commun 288(4):786-788 E.Roydon P, et al., (1991) Proc Natl Acad Sci USA 88:1903-1907
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 Research Articles on PPIB    1. Findings demonstrate that CypB prevents hypoxia-induced cell death through modulation of ubiquitin-mediated CHOP protein degradation, suggesting that CypB may have an important role in the tight regulation of CHOP under hypoxia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PPIB antibodyPathways associated with anti-PPIB antibody
 Reference Product  PubMed Publications
 CRTAP antibody  >22 publications with PPIB and CRTAP
 LEPRE1 antibody  >20 publications with PPIB and LEPRE1
 SERPINH1 antibody  >9 publications with PPIB and SERPINH1
 PDIA3 antibody  >1 publications with PPIB and PDIA3
 FKBP2 antibody  >1 publications with PPIB and FKBP2
 Products by Pathway  Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
 Syndecan-1-mediated Signaling Events Pathway antibodies  Syndecan-1-mediated Signaling Events Pathway Diagram
Diseases associated with anti-PPIB antibodyOrgans/Tissues associated with anti-PPIB antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with PPIB and Nervous System Diseases
 Brain Diseases Antibodies  >3 publications with PPIB and Brain Diseases
 Breast Neoplasms Antibodies  >2 publications with PPIB and Breast Neoplasms
 Inflammation Antibodies  >2 publications with PPIB and Inflammation
 Adenocarcinoma Antibodies  >1 publications with PPIB and Adenocarcinoma
 Liver Neoplasms Antibodies  >1 publications with PPIB and Liver Neoplasms
 Disease Models, Animal Antibodies  >1 publications with PPIB and Disease Models, Animal
 Kidney Diseases Antibodies  >1 publications with PPIB and Kidney Diseases
 Heart Diseases Antibodies  >1 publications with PPIB and Heart Diseases
 Liver Diseases Antibodies  >1 publications with PPIB and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >20 publications with PPIB and Bone
 Blood Antibodies  >12 publications with PPIB and Blood
 Skin Antibodies  >11 publications with PPIB and Skin
 Connective Tissue Antibodies  >6 publications with PPIB and Connective Tissue
 Liver Antibodies  >3 publications with PPIB and Liver
 Brain Antibodies  >3 publications with PPIB and Brain
 Muscle Antibodies  >3 publications with PPIB and Muscle
 Kidney Antibodies  >3 publications with PPIB and Kidney
 Pancreas Antibodies  >2 publications with PPIB and Pancreas
 Heart Antibodies  >2 publications with PPIB and Heart
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