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anti-CST3 antibody :: anti-Human Cystatin C Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS311134 anti-CST3 antibody
Unit / Price
1 mg  /  $690 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cystatin C (CST3), Monoclonal Antibody

 Also Known As   

MAb to Cystatin C

 Product Synonym Names    Monoclonal Antibody to Human Cystatin C
 Product Gene Name   

anti-CST3 antibody

[Similar Products]
 Matching Pairs    Capture Antibody: Cystatin C Clone #Cyst-24 (MBS311128)
Detection Antibody: Cystatin C Clone #Cyst-28 (MBS311134)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 20; NC_000020.10 (23614294..23618574, complement). Location: 20p11.21
 OMIM    105150
 3D Structure    ModBase 3D Structure for P01034
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    Cyst-28
 Host    Host: Mouse. Hybridization of Sp2/0 myeloma cells with spleen cells from Balb/c mice.
Source: Ascites
 Species Reactivity    Human
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 Specificity    Cystatin C
Cystatin C
 Purity/Purification    >90% pure. Protein A Sepharose chromatography. Purity is tested by electrophoresis.
 Form/Format    Purified, Liquid
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 Immunogen    Cystatin C purified from human urine.
 Affinity Constant    Not determined
 Buffer    PBS pH 7.4
 Preservative    0.1% Sodium Azide
 Warnings    This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
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 Preparation and Storage    Store at 2 to 8 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CST3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CST3 antibody    Monoclonal Antibodies to Proteins and Bioactive Peptides
 Applications Tested/Suitable for anti-CST3 antibody   

EIA/ELISA, Immunoassay Antibody Pairs

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NCBI/Uniprot data below describe general gene information for CST3. It may not necessarily be applicable to this product.
 NCBI GI #    296643
 NCBI GeneID    1471
 NCBI Accession #    CAA36497.1 [Other Products]
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 UniProt Primary Accession #    P01034 [Other Products]
 UniProt Secondary Accession #    Q6FGW9; B2R5J9; D3DW42 [Other Products]
 UniProt Related Accession #    P01034 [Other Products]
 Molecular Weight    15,799 Da [Similar Products]
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 NCBI Official Full Name    cystatin C
 NCBI Official Synonym Full Names    cystatin C
 NCBI Official Symbol    CST3 [Similar Products]
 NCBI Official Synonym Symbols   
ARMD11; MGC117328
[Similar Products]
 NCBI Protein Information    cystatin-C; cystatin 3; cystatin-3; gamma-trace; OTTHUMP00000030440; OTTHUMP00000164181; OTTHUMP00000164182; post-gamma-globulin; bA218C14.4 (cystatin C); neuroendocrine basic polypeptide
 UniProt Protein Name    Cystatin-C
 UniProt Synonym Protein Names   
Cystatin-3; Gamma-trace; Neuroendocrine basic polypeptide; Post-gamma-globulin
 Protein Family    Cystatin
 UniProt Gene Name    CST3 [Similar Products]
 UniProt Entry Name    CYTC_HUMAN
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 NCBI Summary for CST3    The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. [provided by RefSeq]
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 UniProt Comments for CST3    CST3: As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. Defects in CST3 are the cause of amyloidosis type 6 (AMYL6); also known as hereditary cerebral hemorrhage with amyloidosis (HCHWA), cerebral amyloid angiopathy (CAA) or cerebroarterial amyloidosis Icelandic type. AMYL6 is a hereditary generalized amyloidosis due to cystatin C amyloid deposition. Cystatin C amyloid accumulates in the walls of arteries, arterioles, and sometimes capillaries and veins of the brain, and in various organs including lymphoid tissue, spleen, salivary glands, and seminal vesicles. Amyloid deposition in the cerebral vessels results in cerebral amyloid angiopathy, cerebral hemorrhage and premature stroke. Cystatin C levels in the cerebrospinal fluid are abnormally low. Genetic variations in CST3 are associated with age- related macular degeneration type 11 (ARMD11). ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Belongs to the cystatin family.

Protein type: Secreted, signal peptide; Inhibitor; Secreted

Chromosomal Location of Human Ortholog: 20p11.21

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; protease binding; beta-amyloid binding; endopeptidase inhibitor activity; cysteine protease inhibitor activity

Biological Process: negative regulation of proteolysis; fibril organization and biogenesis; negative regulation of peptidase activity; defense response; regulation of tissue remodeling

Disease: Macular Degeneration, Age-related, 11; Cerebral Amyloid Angiopathy, Cst3-related
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 Research Articles on CST3    1. The inflammatory status of a patient does not influence the role of cystatin C as a marker of successful aging, nor of glomerular filtration rate.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CST3 antibodyPathways associated with anti-CST3 antibody
 Reference Product  PubMed Publications
 CTSL1 antibody  >20 publications with CST3 and CTSL1
 CTSB antibody  >6 publications with CST3 and CTSB
 CTSD antibody  >4 publications with CST3 and CTSD
 CTSS antibody  >2 publications with CST3 and CTSS
 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Salivary Secretion Pathway antibodies  Salivary Secretion Pathway Diagram
 Salivary Secretion Pathway antibodies  Salivary Secretion Pathway Diagram
Diseases associated with anti-CST3 antibodyOrgans/Tissues associated with anti-CST3 antibody
 Disease Name  Pubmed Publications
 Female Urogenital Diseases Antibodies  >455 publications with CST3 and Female Urogenital Diseases
 Cardiovascular Diseases Antibodies  >281 publications with CST3 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >214 publications with CST3 and Nervous System Diseases
 Vascular Diseases Antibodies  >213 publications with CST3 and Vascular Diseases
 Renal Insufficiency Antibodies  >185 publications with CST3 and Renal Insufficiency
 Neoplasms Antibodies  >108 publications with CST3 and Neoplasms
 Proteinuria Antibodies  >83 publications with CST3 and Proteinuria
 Dementia Antibodies  >83 publications with CST3 and Dementia
 Mental Disorders Antibodies  >81 publications with CST3 and Mental Disorders
 Kidney Failure, Chronic Antibodies  >77 publications with CST3 and Kidney Failure, Chronic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >858 publications with CST3 and Blood
 Kidney Antibodies  >576 publications with CST3 and Kidney
 Brain Antibodies  >152 publications with CST3 and Brain
 Vascular Antibodies  >93 publications with CST3 and Vascular
 Heart Antibodies  >82 publications with CST3 and Heart
 Liver Antibodies  >76 publications with CST3 and Liver
 Muscle Antibodies  >60 publications with CST3 and Muscle
 Bone Antibodies  >34 publications with CST3 and Bone
 Lung Antibodies  >29 publications with CST3 and Lung
 Nerve Antibodies  >28 publications with CST3 and Nerve
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