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anti-CYR61 antibody :: Mouse Cysteine-Rich Angiogenic Inducer 61 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS140242 anti-CYR61 antibody
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cysteine-Rich Angiogenic Inducer 61 (CYR61), Monoclonal Antibody

 Also Known As   

Mouse Anti Human Cysteine-Rich Angiogenic Inducer 61

 Product Synonym Names    CYR61 Antibody; Cysteine-Rich Angiogenic Inducer 61, Mouse Anti Human; CYR61; Protein CYR61; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10; IGF-binding protein 10; IGFBP-10; IBP-10; Protein GIG1; CCN family member 1; CCN1; GIG1; IGFBP10
 Product Gene Name   

anti-CYR61 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602369
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 Clonality    Monoclonal
 Isotype    IgG1 heavy chain and kappa light chain
 Clone Number    P3H3AT
 Host    Mouse
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 Purity/Purification    CYR61 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
 Form/Format    1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
Sterile Filtered clear solution.
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 Immunogen    Anti-human CYR61 mAb, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CYR61 amino acids 168-242 purified from E Coli.
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 Preparation and Storage    For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
12 months at -20 degree C. 1 month at 4 degree C.
 Other Notes    Small volumes of anti-CYR61 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CYR61 antibody

   Introduction: CYR61 is a growth factor-inducible, immediate-early gene that has multifaceted activities in various cancers. CYR61 is a secreted, cysteine-rich, heparin-binding protein which is encoded by a growth factor-inducible immediate-early gene. Acting as an extracellular, matrix-associated signaling molecule, CYR61 promotes the adhesion of endothelial cells through interaction with integrin and enhances growth factor-induced DNA synthesis in the same cell type.
 Product Categories/Family for anti-CYR61 antibody    ANTI-HUMAN CYTOKINES; Monoclonal Antibodies; Anti Human Cytokine
 Applications Tested/Suitable for anti-CYR61 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CYR61 antibody    CYR61 antibody has been tested by ELISA, Western blot and immunohistochemistry analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot is 1:250~1:1,000 and immunohistochemistry analysis is 1:50~100. Recommended starting dilution for Western blot is 1:250 and Immunohistochemistry is 1:50.
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NCBI/Uniprot data below describe general gene information for CYR61. It may not necessarily be applicable to this product.
 NCBI GI #    31542331
 NCBI GeneID    3491
 NCBI Accession #    NP_001545.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001554.4 [Other Products]
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 UniProt Secondary Accession #    O14934; O43775; Q9BZL7 [Other Products]
 UniProt Related Accession #    O00622 [Other Products]
 Molecular Weight    42,027 Da
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 NCBI Official Full Name    protein CYR61
 NCBI Official Synonym Full Names    cysteine-rich, angiogenic inducer, 61
 NCBI Official Symbol    CYR61 [Similar Products]
 NCBI Official Synonym Symbols   
CCN1; GIG1; IGFBP10
[Similar Products]
 NCBI Protein Information    protein CYR61; CCN family member 1; IBP-10; IGF-binding protein 10; IGFBP-10; cysteine-rich heparin-binding protein 61; cysteine-rich, anigogenic inducer, 61; insulin-like growth factor-binding protein 10
 UniProt Protein Name    Protein CYR61
 UniProt Synonym Protein Names   
CCN family member 1; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10; IBP-10; IGF-binding protein 10; IGFBP-10; Protein GIG1
 Protein Family    Protein
 UniProt Gene Name    CYR61 [Similar Products]
 UniProt Synonym Gene Names    CCN1; GIG1; IGFBP10; IBP-10; IGF-binding protein 10; IGFBP-10 [Similar Products]
 UniProt Entry Name    CYR61_HUMAN
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 NCBI Summary for CYR61    The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]
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 UniProt Comments for CYR61    CYR61: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Belongs to the CCN family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p22.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix

Molecular Function: integrin binding; heparin binding; insulin-like growth factor binding; extracellular matrix binding

Biological Process: anatomical structure morphogenesis; extracellular matrix organization and biogenesis; positive regulation of caspase activity; chemotaxis; intussusceptive angiogenesis; osteoblast differentiation; positive regulation of osteoblast differentiation; cell proliferation; cell-cell signaling; positive regulation of protein kinase activity; positive regulation of osteoblast proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; regulation of cell growth; cell adhesion; positive regulation of BMP signaling pathway; negative regulation of apoptosis; positive regulation of cell migration
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 Research Articles on CYR61    1. integrin alpha(v) beta(3) and AMP-Activated Protein Kinases mediate CCN1-induced endothelial cell migration and tube formation independent of intracellular ATP levels alteration.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CYR61 antibodyPathways associated with anti-CYR61 antibody
 Reference Product  PubMed Publications
 JUN antibody  >85 publications with CYR61 and JUN
 FOS antibody  >19 publications with CYR61 and FOS
 CTNNB1 antibody  >14 publications with CYR61 and CTNNB1
 SRF antibody  >5 publications with CYR61 and SRF
 MKL1 antibody  >4 publications with CYR61 and MKL1
 ITGB2 antibody  >1 publications with CYR61 and ITGB2
 ITGAV antibody  >1 publications with CYR61 and ITGAV
 Products by Pathway  Pathway Diagram
 Hypertrophy Model Pathway antibodies  Hypertrophy Model Pathway Diagram
 Oncostatin M Signaling Pathway antibodies  Oncostatin M Signaling Pathway Diagram
 Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies  Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
 RhoA Signaling Pathway antibodies  RhoA Signaling Pathway Diagram
 Amb2 Integrin Signaling Pathway antibodies  Amb2 Integrin Signaling Pathway Diagram
Diseases associated with anti-CYR61 antibodyOrgans/Tissues associated with anti-CYR61 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >83 publications with CYR61 and Carcinoma
 Inflammation Antibodies  >51 publications with CYR61 and Inflammation
 Disease Models, Animal Antibodies  >45 publications with CYR61 and Disease Models, Animal
 Breast Neoplasms Antibodies  >40 publications with CYR61 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >40 publications with CYR61 and Neoplasm Metastasis
 Fibrosis Antibodies  >37 publications with CYR61 and Fibrosis
 Nervous System Diseases Antibodies  >29 publications with CYR61 and Nervous System Diseases
 Necrosis Antibodies  >25 publications with CYR61 and Necrosis
 Neoplasms, Experimental Antibodies  >23 publications with CYR61 and Neoplasms, Experimental
 Brain Diseases Antibodies  >22 publications with CYR61 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >179 publications with CYR61 and Connective Tissue
 Vascular Antibodies  >127 publications with CYR61 and Vascular
 Bone Antibodies  >77 publications with CYR61 and Bone
 Muscle Antibodies  >76 publications with CYR61 and Muscle
 Embryonic Tissue Antibodies  >53 publications with CYR61 and Embryonic Tissue
 Lung Antibodies  >50 publications with CYR61 and Lung
 Brain Antibodies  >38 publications with CYR61 and Brain
 Prostate Antibodies  >31 publications with CYR61 and Prostate
 Skin Antibodies  >29 publications with CYR61 and Skin
 Kidney Antibodies  >27 publications with CYR61 and Kidney
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