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anti-CFTR antibody :: Mouse anti-Human Cystic Fibrosis Transmembrane Conductance Regulator Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS604644 anti-CFTR antibody
Unit / Price
0.2 mg  /  $765 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), Monoclonal Antibody

 Also Known As   

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

 Product Synonym Names    Anti -Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)
 Product Gene Name   

anti-CFTR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 7; NC_000007.13 (117120017..117308719). Location: 7q31.2
 OMIM    219700
 3D Structure    ModBase 3D Structure for P13569
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    4i35
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes CFTR, Mr 170kDa. Species Crossreactivity: Human.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in ~530ul of 0.1M Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.05% sodium azide before the addition of glycerol to 30%.
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 Immunogen    Fusion Protein corresponding to residues 1197-1480 of human cystic ?brosis transmembrane conductance regulator (CFTR). The epitope maps within amino acids 1365-1395.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-CFTR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CFTR antibody    Antibodies; Abs to Disease Markers
 Applications Tested/Suitable for anti-CFTR antibody   

ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

 Application Notes for anti-CFTR antibody    Suitable for use in ELISA, Immunoprecipitation, Immunohistochemistry and Western Blot.
Dilution: Immunoprecipitation: Reported to immunoprecipitate CFTR.1
Immunohistochemistry: Reported to immunostain CFTR in human pancreatic tissue sections.1
Immunoblot Analysis: 0.5-2ug/ml detects CFTR from 20-50ug of human T84 colon carcinoma epithelial RIPA cell lysates. 0.5-2ug/ml of a previous lot detected CFTR from CFTR-transfected BHK2. Note: Do not boil the lysate. Instead incubate at 37 degree C for 30 minutes. CFTR can run as a diffuse protein on SDS-PAGE. T84 cell lysate was resolved by electrophoresis, transferred to nitrocellulose and probed with anti-CFTR (0.5ug/ml). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and a chemiluminescence detection system.
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NCBI/Uniprot data below describe general gene information for CFTR. It may not necessarily be applicable to this product.
 NCBI GI #    90421313
 NCBI GeneID    1080
 NCBI Accession #    NP_000483.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000492.3 [Other Products]
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 UniProt Primary Accession #    P13569 [Other Products]
 UniProt Secondary Accession #    Q20BG8; Q20BH2; Q2I0A1; Q2I102 [Other Products]
 UniProt Related Accession #    P13569; Q16049; Q20BH0; Q20BI4; Q20BI6; Q20BJ8; Q2I0A3; Q2I0A9; Q5I6F9; Q5I6N4 [Other Products]
 Molecular Weight    168,142 Da [Similar Products]
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 NCBI Official Full Name    cystic fibrosis transmembrane conductance regulator
 NCBI Official Synonym Full Names    cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
 NCBI Official Symbol    CFTR [Similar Products]
 NCBI Official Synonym Symbols   
CF; MRP7; ABC35; ABCC7; CFTR/MRP; TNR-CFTR; dJ760C5.1
[Similar Products]
 NCBI Protein Information    cystic fibrosis transmembrane conductance regulator; OTTHUMP00000024694; OTTHUMP00000196524; cAMP-dependent chloride channel; channel conductance-controlling ATPase; ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7
 UniProt Protein Name    Cystic fibrosis transmembrane conductance regulator
 UniProt Synonym Protein Names   
ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase (EC:3.6.3.49); cAMP-dependent chloride channel
 Protein Family    Cystic fibrosis transmembrane conductance regulator
 UniProt Gene Name    CFTR [Similar Products]
 UniProt Synonym Gene Names    ABCC7; CFTR [Similar Products]
 UniProt Entry Name    CFTR_HUMAN
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 NCBI Summary for CFTR    This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene. [provided by RefSeq]
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 UniProt Comments for CFTR    CFTR: a member of the MRP subfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. Functions as a chloride channel and controls the regulation of other transport pathways. Mutations have been observed in patients with the autosomal recessive disorders cystic fibrosis (CF) and congenital bilateral aplasia of the vas deferens (CBAVD). Alternative splice

Protein type: Transporter; Membrane protein, multi-pass; Channel, chloride; Transporter, ABC family; Hydrolase; EC 3.6.3.49; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q31.2

Cellular Component: recycling endosome; protein complex; cytoplasmic vesicle membrane; cell surface; microvillus; early endosome membrane; basolateral plasma membrane; cytoplasm; early endosome; apical plasma membrane; plasma membrane

Molecular Function: bicarbonate transmembrane transporter activity; protein binding; chloride channel activity; chloride channel inhibitor activity; enzyme binding; chloride transmembrane transporter activity; ATP-binding and phosphorylation-dependent chloride channel activity; channel-conductance-controlling ATPase activity; ATP binding; PDZ domain binding

Biological Process: response to drug; intracellular pH elevation; response to peptide hormone stimulus; cholesterol transport; iodide transport; transepithelial chloride transport; water transport; membrane hyperpolarization; respiratory gaseous exchange; positive regulation of vasodilation; cholesterol biosynthetic process; vasodilation; cellular response to hormone stimulus; transport; response to estrogen stimulus; bicarbonate transport; response to cytokine stimulus; transmembrane transport; sperm capacitation; lung development

Disease: Vas Deferens, Congenital Bilateral Aplasia Of; Bronchiectasis With Or Without Elevated Sweat Chloride 1; Cystic Fibrosis; Pancreatitis, Hereditary
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 Research Articles on CFTR    1. Spectrum of CFTR gene mutations in Iranian Azeri Turkish patients with cystic fibrosis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CFTR antibodyPathways associated with anti-CFTR antibody
 Reference Product  PubMed Publications
 PDZK1 antibody  >15 publications with CFTR and PDZK1
 GOPC antibody  >14 publications with CFTR and GOPC
 STX1A antibody  >13 publications with CFTR and STX1A
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
Diseases associated with anti-CFTR antibody
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >6471 publications with CFTR and Fibrosis
 Cystic Fibrosis Antibodies  >6466 publications with CFTR and Cystic Fibrosis
 Lung Diseases Antibodies  >3623 publications with CFTR and Lung Diseases
 Inflammation Antibodies  >391 publications with CFTR and Inflammation
 Pancreatitis Antibodies  >268 publications with CFTR and Pancreatitis
 Infertility, Male Antibodies  >240 publications with CFTR and Infertility, Male
 Congenital Abnormalities Antibodies  >203 publications with CFTR and Congenital Abnormalities
 Pancreatitis, Chronic Antibodies  >197 publications with CFTR and Pancreatitis, Chronic
 Neoplasms Antibodies  >180 publications with CFTR and Neoplasms
 Intestinal Diseases Antibodies  >158 publications with CFTR and Intestinal Diseases
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