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anti-KRT14 antibody :: Mouse anti-Human Cytokeratin 14 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS370135
Unit / Price
5 Control Slides  /  $130 +1 FREE 8GB USB
0.1 mL (Concentrate)  /  $160 +1 FREE 8GB USB
3 ml (Prediluted)  /  $165 +1 FREE 8GB USB
7 ml (Prediluted)  /  $210 +1 FREE 8GB USB
0.5 mL (Concentrate)  /  $230 +1 FREE 8GB USB
15 ml (Prediluted)  /  $310 +1 FREE 8GB USB
1 mL (Concentrate)  /  $375 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cytokeratin 14 (KRT14), Monoclonal Antibody

 Also Known As   

Cytokeratin 14

 Product Gene Name   

anti-KRT14 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    125595
 3D Structure    ModBase 3D Structure for P02533
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 Clonality    Monoclonal
 Isotype    IgG3
 Clone Number    LL002
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Cytokeratin 14 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
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 Control    Squamous Mucosa, Squamous Carcinoma
 Localization    Cytoplasmic
 Reactivity Note    Paraffin, Frozen
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 Preparation and Storage    Store at 2 to 8 degree C in the dark.
 Other Notes    Small volumes of anti-KRT14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KRT14 antibody

   Cytokeratin 14 is a Type I polypeptide found in basal cells of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells. It is usually found as a heterotetramer with two cytokeratin 5 molecules, and a Type II keratin. Together, they form the cytoskeleton of epithelial cells. Mutations in the genes for these cytokeratins are associated with Epidermolysis Bullosa Simplex. Cytokeratin 14 has been studied as a prognostic marker in Breast Cancer. This antibody labels the basal layer of stratifying squamous and non-squamous epithelia. The staining pattern is cytoplasmic. It recognizes Basal Cell Carcinomas and Squamous Cell Carcinomas. Anti-CK14 has been demonstrated to be useful in differentiating Squamous Cell Carcinomas from other epithelial tumors. This antibody has also been useful in separating oncocytic tumors of the kidney from renal mimics, as well as in determining metaplastic Carcinomas of the Breast.
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 Dilution Information of anti-KRT14 antibody    anti-KRT14 antibody Dilution Information image
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 Immunohistochemistry (IHC) of anti-KRT14 antibody    anti-KRT14 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for KRT14. It may not necessarily be applicable to this product.
 NCBI GI #    355568680
 NCBI Accession #    EHH24961.1 [Other Products]
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 UniProt Primary Accession #    P02533 [Other Products]
 UniProt Secondary Accession #    Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4 [Other Products]
 Molecular Weight    51,561 Da [Similar Products]
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 NCBI Official Full Name    Cytokeratin-14
 UniProt Protein Name    Keratin, type I cytoskeletal 14
 UniProt Synonym Protein Names   
Cytokeratin-14; CK-14; Keratin-14
 Protein Family    Keratin
 UniProt Gene Name    KRT14 [Similar Products]
 UniProt Synonym Gene Names    CK-14; K14 [Similar Products]
 UniProt Entry Name    K1C14_HUMAN
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 UniProt Comments for KRT14    Function: The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. Ref.13

Subunit structure: Heterotetramer of two type I and two type II keratins. disulfide-linked keratin-14 associates with keratin-5. Interacts with TRADD and with keratin filaments. Associates with other type I keratins. Ref.12 Ref.13 Ref.16

Subcellular location: Cytoplasm. Nucleus. Note: Expressed in both as a filamentous pattern. Ref.13 Ref.16

Tissue specificity: Detected in the basal layer, lowered within the more apically located layers specifically in the stratum spinosum, stratum granulosum but is not detected in stratum corneum. Strongly expressed in the outer root sheath of anagen follicles but not in the germinative matrix, inner root sheath or hair. Found in keratinocytes surrounding the club hair during telogen. Ref.11

Post-translational modification: A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament cage around the nucleus.

Involvement in disease: Epidermolysis bullosa simplex, Dowling-Meara type (DM-EBS) [MIM:131760]: A severe form of intraepidermal epidermolysis bullosa characterized by generalized herpetiform blistering, milia formation, dystrophic nails, and mucous membrane involvement.Note: The disease is caused by mutations affecting the gene represented in this entry.Epidermolysis bullosa simplex, Weber-Cockayne type (WC-EBS) [MIM:131800]: A form of intraepidermal epidermolysis bullosa characterized by blistering limited to palmar and plantar areas of the skin.Note: The disease is caused by mutations affecting the gene represented in this entry.Epidermolysis bullosa simplex, Koebner type (K-EBS) [MIM:131900]: A form of intraepidermal epidermolysis bullosa characterized by generalized skin blistering. The phenotype is not fundamentally distinct from the Dowling-Meara type, although it is less severe.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.10 Ref.17 Ref.19 Ref.28 Ref.29 Ref.31 Ref.32 Ref.33 Ref.41Epidermolysis bullosa simplex, autosomal recessive (AREBS) [MIM:601001]: An intraepidermal epidermolysis bullosa characterized by localized blistering on the dorsal, lateral and plantar surfaces of the feet.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.21Naegeli-Franceschetti-Jadassohn syndrome (NFJS) [MIM:161000]: A rare autosomal dominant form of ectodermal dysplasia. The cardinal features are absence of dermatoglyphics (fingerprints), reticular cutaneous hyperpigmentation (starting at about the age of 2 years without a preceding inflammatory stage), palmoplantar keratoderma, hypohidrosis with diminished sweat gland function and discomfort provoked by heat, nail dystrophy, and tooth enamel defects.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.39Dermatopathia pigmentosa reticularis (DPR) [MIM:125595]: A rare ectodermal dysplasia characterized by lifelong persistent reticulate hyperpigmentation, non-cicatricial alopecia, and nail dystrophy. Variable features include adermatoglyphia, hypohidrosis or hyperhidrosis, and palmoplantar hyperkeratosis.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.39

Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sequence similarities: Belongs to the intermediate filament family.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KRT14 antibodyDiseases associated with anti-KRT14 antibody
 Reference Product  PubMed Publications
 KRT5 antibody  >73 publications with KRT14 and KRT5
 EGFR antibody  >7 publications with KRT14 and EGFR
 DST antibody  >2 publications with KRT14 and DST
 IVL antibody  >1 publications with KRT14 and IVL
 CREBBP antibody  >1 publications with KRT14 and CREBBP
 Disease Name  Pubmed Publications
 Epidermolysis Bullosa Simplex Antibodies  >88 publications with KRT14 and Epidermolysis Bullosa Simplex
 Neoplasms Antibodies  >80 publications with KRT14 and Neoplasms
 Carcinoma Antibodies  >56 publications with KRT14 and Carcinoma
 Carcinoma, Squamous Cell Antibodies  >36 publications with KRT14 and Carcinoma, Squamous Cell
 Disease Models, Animal Antibodies  >21 publications with KRT14 and Disease Models, Animal
 Hyperplasia Antibodies  >19 publications with KRT14 and Hyperplasia
 Skin Neoplasms Antibodies  >18 publications with KRT14 and Skin Neoplasms
 Breast Neoplasms Antibodies  >17 publications with KRT14 and Breast Neoplasms
 Necrosis Antibodies  >13 publications with KRT14 and Necrosis
 Cell Transformation, Neoplastic Antibodies  >13 publications with KRT14 and Cell Transformation, Neoplastic
Organs/Tissues associated with anti-KRT14 antibody
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >145 publications with KRT14 and Skin
 Blood Antibodies  >23 publications with KRT14 and Blood
 Mouth Antibodies  >15 publications with KRT14 and Mouth
 Lung Antibodies  >8 publications with KRT14 and Lung
 Esophagus Antibodies  >8 publications with KRT14 and Esophagus
 Mammary Gland Antibodies  >7 publications with KRT14 and Mammary Gland
 Eye Antibodies  >6 publications with KRT14 and Eye
 Connective Tissue Antibodies  >6 publications with KRT14 and Connective Tissue
 Liver Antibodies  >6 publications with KRT14 and Liver
 Cervix Antibodies  >5 publications with KRT14 and Cervix
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