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anti-KRT18 antibody :: Rabbit anti-Human Cytokeratin 18 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS684047
Testing Data
Unit / Price
1 ml (Prediluted)  /  $175 +1 FREE 8GB USB
0.04 mL  /  $185 +1 FREE 8GB USB
0.1 mL  /  $270 +1 FREE 8GB USB
7 ml (Prediluted)  /  $285 +1 FREE 8GB USB
0.2 mL  /  $335 +1 FREE 8GB USB
15 ml (Prediluted)  /  $385 +1 FREE 8GB USB
0.5 mL  /  $415 +1 FREE 8GB USB
1 mL  /  $615 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cytokeratin 18 (KRT18), Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti - Cytokeratin 18

 Product Gene Name   

anti-KRT18 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.12 (52948871..52952901). Location: 12q13
 OMIM    148070
 3D Structure    ModBase 3D Structure for P05783
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 Clonality    Monoclonal
 Clone Number    R20-H
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Human
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 Immunogen    Peptide derived from C-terminal region of human cytokeratin 18
 Storage Buffer    20 mM Tris-HCI, pH 8.0
 Stabilizer    20 mg/ml BSA
 Preservative    0.05% NaN3
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 Preparation and Storage    Store at +4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
 Other Notes    Small volumes of anti-KRT18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-KRT18 antibody   

Immunohistochemistry (IHC) - Formalin/Paraffin

 Application Notes for anti-KRT18 antibody    IHC-P dilution 1:100 - 1:300; IHC-Fr application and dilution to be tested by the user
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 Testing Data of anti-KRT18 antibody    anti-KRT18 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for KRT18. It may not necessarily be applicable to this product.
 NCBI GI #    125083
 NCBI GeneID    3875
 NCBI Accession #    P05783.2 [Other Products]
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 UniProt Primary Accession #    P05783 [Other Products]
 UniProt Secondary Accession #    Q53G38; Q5U0N8; Q9BW26 [Other Products]
 UniProt Related Accession #    P05783 [Other Products]
 Molecular Weight    48,058 Da [Similar Products]
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 NCBI Official Full Name    Keratin, type I cytoskeletal 18
 NCBI Official Synonym Full Names    keratin 18
 NCBI Official Symbol    KRT18 [Similar Products]
 NCBI Official Synonym Symbols   
K18; CYK18
[Similar Products]
 NCBI Protein Information    keratin, type I cytoskeletal 18; CK-18; keratin-18; cytokeratin 18; cytokeratin-18; cell proliferation-inducing protein 46; cell proliferation-inducing gene 46 protein
 UniProt Protein Name    Keratin, type I cytoskeletal 18
 UniProt Synonym Protein Names   
Cell proliferation-inducing gene 46 protein; Cytokeratin-18; CK-18; Keratin-18
 Protein Family    Keratin
 UniProt Gene Name    KRT18 [Similar Products]
 UniProt Synonym Gene Names    CYK18; CK-18; K18 [Similar Products]
 UniProt Entry Name    K1C18_HUMAN
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 NCBI Summary for KRT18    KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KRT18    Function: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells

By similarity. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. Ref.11 Ref.13 Ref.15 Ref.16 Ref.22 Ref.25 Ref.26

Subunit structure: Heterotetramer of two type I and two type II keratins. KRT18 associates with KRT8. Interacts with the thrombin-antithrombin complex

By similarity. Interacts with PNN, HCV core protein and mutated CFTR. Interacts with YWHAE, YWHAH and YWHAZ only when phosphorylated. Interacts with DNAJB6, TCHP and TRADD. Ref.14 Ref.16 Ref.17 Ref.18 Ref.19 Ref.22 Ref.23

Subcellular location: Cytoplasm › perinuclear region. Nucleus › nucleolus Ref.22 Ref.25 Ref.35.

Tissue specificity: Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. Ref.1 Ref.7 Ref.8 Ref.26

Induction: By IL6/interleukin-6. Ref.26

Post-translational modification: Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6. Ref.11 Ref.14 Ref.16 Ref.21 Ref.25 Ref.26Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7. Ref.15O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation.

Involvement in disease: Cirrhosis (CIRRH) [MIM:215600]: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.37 Ref.38

Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sequence similarities: Belongs to the intermediate filament family.
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 Research Articles on KRT18    1. This first human study suggests that cytokeratin 18 (marker of apoptosis) might be a serological predictive marker for acute pancreatitis for disease activity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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