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anti-KRT19 antibody :: Rabbit Cytokeratin 19 (KRT19) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS4380083
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cytokeratin 19 (KRT19), Monoclonal Antibody

★Popular Item★
 Also Known As   

Cytokeratin 19 (KRT19) (Pancreatic Stem Cell Marker)

 Product Synonym Names    k19; k1cs; Keratin 19 Keratin Type i 40kD; krt19
 Product Gene Name   

anti-KRT19 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P08727
 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    KRT19/1959R
 Host    Rabbit
 Species Reactivity    Human, Mouse. Others not known.
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 Specificity    This Ab reacts with the rod domain of human cytokeratin 19 (CK19), a polypeptide of 40kDa. CK19 is expressed in sweat gland, mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, and ectocervical epithelium. Anti-CK19 reacts with a wide variety of epithelial malignancies including adenocarcinomas of the colon, stomach, pancreas, biliary tract, liver, and breast. Perhaps the most useful application is the identification of thyroid carcinoma of the papillary type, although 50%-60% of follicular carcinomas are also labeled. Anti-CK19 is a useful marker for detection of tumor cells in lymph nodes, peripheral blood, bone marrow and breast cancer.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Immunogen    Recombinant full-length human KRT19 protein
 Cellular Localization    Cytoplasmic
 Hu-chromosome Location    17q21.2
 Positive Control    MCF-7, HeLa cells, Breast Cancer
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of anti-KRT19 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-KRT19 antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

 Application Notes for anti-KRT19 antibody    FC/FACS: 0.5-1ug/million cells
IF: 1-2ug/ml
IHC-F: 0.5-1ug/ml for 30 min at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
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 Immunohistochemistry (IHC) of anti-KRT19 antibody    Formalin-fixed, paraffin-embedded human Colon stained with Cytokeratin 19 Rabbit Recombinant Monoclonal Antibody (KRT19/1959R).
anti-KRT19 antibody Immunohistochemistry (IHC) (IHC) image
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 SDS-Page of anti-KRT19 antibody    SDS-PAGE Analysis of Purified Cytokeratin 19 Rabbit Recombinant Monoclonal Antibody (KRT19/1959R).
anti-KRT19 antibody SDS-Page image
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NCBI/Uniprot data below describe general gene information for KRT19. It may not necessarily be applicable to this product.
 NCBI GI #    24234699
 NCBI GeneID    3880
 NCBI Accession #    NP_002267.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002276.4 [Other Products]
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 UniProt Primary Accession #    P08727 [Other Products]
 UniProt Secondary Accession #    Q5XG83; Q6NW33; Q7L5M9; Q96A53; Q96FV1; Q9BYF9; Q9P1Y4; B2R874 [Other Products]
 UniProt Related Accession #    P08727 [Other Products]
 Molecular Weight    40kDa
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 NCBI Official Full Name    keratin, type I cytoskeletal 19
 NCBI Official Synonym Full Names    keratin 19
 NCBI Official Symbol    KRT19 [Similar Products]
 NCBI Official Synonym Symbols   
K19; CK19; K1CS
[Similar Products]
 NCBI Protein Information    keratin, type I cytoskeletal 19
 UniProt Protein Name    Keratin, type I cytoskeletal 19
 UniProt Synonym Protein Names   
Cytokeratin-19; CK-19; Keratin-19; K19
 Protein Family    Keratin
 UniProt Gene Name    KRT19 [Similar Products]
 UniProt Synonym Gene Names    CK-19; K19 [Similar Products]
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 NCBI Summary for KRT19    The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KRT19    Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
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Product References and Citations for anti-KRT19 antibody

   Bartek J et. al. Int J Cancer 36:299-306 (1985). Bartek J et. al. J Cell Sci 75:17-33 (1985). Lewis BC et. al. Genes Dev 17:3127-38 (2003). Nightingale J et. al. J Am Soc Nephrol 15:21-32 (2004).
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 Research Articles on KRT19    1. High expression of CK-19 is associated with intrahepatic cholangiocarcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KRT19 antibodyPathways associated with anti-KRT19 antibody
 Reference Product  PubMed Publications
 KRT15 antibody  >3 publications with KRT19 and KRT15
 KRT6B antibody  >1 publications with KRT19 and KRT6B
 FANCG antibody  >1 publications with KRT19 and FANCG
 Products by Pathway  Pathway Diagram
 Signaling Mediated By P38-alpha And P38-beta Pathway antibodies  Signaling Mediated By P38-alpha And P38-beta Pathway Diagram
Diseases associated with anti-KRT19 antibodyOrgans/Tissues associated with anti-KRT19 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >42 publications with KRT19 and Neoplasms
 Carcinoma Antibodies  >25 publications with KRT19 and Carcinoma
 Adenocarcinoma Antibodies  >13 publications with KRT19 and Adenocarcinoma
 Breast Neoplasms Antibodies  >9 publications with KRT19 and Breast Neoplasms
 Liver Diseases Antibodies  >8 publications with KRT19 and Liver Diseases
 Neoplasm Metastasis Antibodies  >7 publications with KRT19 and Neoplasm Metastasis
 Liver Neoplasms Antibodies  >5 publications with KRT19 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >5 publications with KRT19 and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >4 publications with KRT19 and Kidney Diseases
 Fibrosis Antibodies  >4 publications with KRT19 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >12 publications with KRT19 and Liver
 Blood Antibodies  >12 publications with KRT19 and Blood
 Lung Antibodies  >6 publications with KRT19 and Lung
 Bone Antibodies  >5 publications with KRT19 and Bone
 Kidney Antibodies  >4 publications with KRT19 and Kidney
 Thyroid Antibodies  >4 publications with KRT19 and Thyroid
 Eye Antibodies  >3 publications with KRT19 and Eye
 Stomach Antibodies  >3 publications with KRT19 and Stomach
 Pancreas Antibodies  >3 publications with KRT19 and Pancreas
 Lymph Antibodies  >2 publications with KRT19 and Lymph
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