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anti-KRT7 antibody :: Mouse Cytokeratin 7 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS395037 anti-KRT7 antibody
Unit / Price
0.1 mg  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cytokeratin 7 (KRT7), Monoclonal Antibody

★Popular Item★
 Also Known As   

Cytokeratin 7

 Product Gene Name   

anti-KRT7 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.11 (52626954..52642709). Location: 12q13.13
 OMIM    148059
 3D Structure    ModBase 3D Structure for P08729
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    RCK105
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat, Hamster, Canine, Swine, Feline
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 Purity/Purification    Protein A/G Chromatography
 Form/Format    Provided as solution in phosphate buffered saline with 0.08% sodium azide
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 Immunogen    Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with a cytokeratins from the human bladder carcinoma cell line T24 and SP2/0-Ag14 mouse myeloma cells.
 Positive Control    Cytokeratin 7 is present in a subgroup of glandular epithelia and their tumors, as well as transitional epithelium and transitional carcinoma.
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 Preparation and Storage    Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles
 Other Notes    Small volumes of anti-KRT7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KRT7 antibody

   Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4.9 ? 7.8. The individual human cytokeratins are numbered 1 to 20.
 Product Categories/Family for anti-KRT7 antibody    Monoclonal Antibody; Structural Proteins
 Applications Tested/Suitable for anti-KRT7 antibody   

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

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NCBI/Uniprot data below describe general gene information for KRT7. It may not necessarily be applicable to this product.
 NCBI GI #    67782365
 NCBI GeneID    3855
 NCBI Accession #    NP_005547.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_005556.3 [Other Products]
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 UniProt Primary Accession #    P08729 [Other Products]
 UniProt Secondary Accession #    Q92676; Q9BUD8; Q9Y3R7 [Other Products]
 UniProt Related Accession #    P08729 [Other Products]
 Molecular Weight    51,386 Da [Similar Products]
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 NCBI Official Full Name    keratin, type II cytoskeletal 7
 NCBI Official Synonym Full Names    keratin 7
 NCBI Official Symbol    KRT7 [Similar Products]
 NCBI Official Synonym Symbols   
K7; CK7; SCL; K2C7
[Similar Products]
 NCBI Protein Information    keratin, type II cytoskeletal 7; CK-7; keratin-7; sarcolectin; cytokeratin 7; cytokeratin-7; type-II keratin Kb7; type II mesothelial keratin K7; keratin, 55K type II cytoskeletal; keratin, simple epithelial type I, K7
 UniProt Protein Name    Keratin, type II cytoskeletal 7
 UniProt Synonym Protein Names   
Cytokeratin-7; CK-7; Keratin-7; K7; Sarcolectin; Type-II keratin Kb7
 Protein Family    Keratin
 UniProt Gene Name    KRT7 [Similar Products]
 UniProt Synonym Gene Names    SCL; CK-7; K7 [Similar Products]
 UniProt Entry Name    K2C7_HUMAN
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 NCBI Summary for KRT7    The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KRT7    Function: Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7). Ref.3 Ref.9

Subunit structure: Heterotetramer of two type I and two type II keratins. Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit EIF3S10 and with HPV16 E7. Ref.8 Ref.9

Subcellular location: Cytoplasm Ref.2.

Tissue specificity: Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus. Ref.1 Ref.4

Induction: Up-regulated by retinoic acid. Ref.2

Post-translational modification: Arg-20 is dimethylated, probably to asymmetric dimethylarginine. Ref.7

Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sequence similarities: Belongs to the intermediate filament family.

Mass spectrometry: Molecular mass is 51203.48 Da from positions 2 - 469. Determined by MALDI. Ref.10

Sequence caution: The sequence CAA26956.2 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.
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 Research Articles on KRT7    1. CK7 + centrilobular hepatocytes occur relatively frequently in non-neoplastic liver disease, associated with centrilobular scarring and CK7-positive periportal hepatocytes, and appear to be a non-specific phenomenon of underlying disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KRT7 antibodyPathways associated with anti-KRT7 antibody
 Reference Product  PubMed Publications
 MUC2 antibody  >18 publications with KRT7 and MUC2
 CDX2 antibody  >17 publications with KRT7 and CDX2
 MUC1 antibody  >10 publications with KRT7 and MUC1
 PIP antibody  >5 publications with KRT7 and PIP
 EIF3A antibody  >1 publications with KRT7 and EIF3A
 Products by Pathway  Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
Organs/Tissues associated with anti-KRT7 antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >60 publications with KRT7 and Lung
 Stomach Antibodies  >45 publications with KRT7 and Stomach
 Ovary Antibodies  >37 publications with KRT7 and Ovary
 Thyroid Antibodies  >36 publications with KRT7 and Thyroid
 Intestine Antibodies  >34 publications with KRT7 and Intestine
 Lymph Node Antibodies  >28 publications with KRT7 and Lymph Node
 Placenta Antibodies  >27 publications with KRT7 and Placenta
 Prostate Antibodies  >20 publications with KRT7 and Prostate
 Vascular Antibodies  >17 publications with KRT7 and Vascular
 Uterus Antibodies  >13 publications with KRT7 and Uterus
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