NP_001243211.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
keratin, type II cytoskeletal 8 isoform 1
NCBI Official Synonym Full Names
keratin 8
NCBI Official Synonym Symbols
K8; KO; CK8; CK-8; CYK8; K2C8; CARD2 [Similar Products]
NCBI Protein Information
keratin, type II cytoskeletal 8
UniProt Protein Name
Keratin, type II cytoskeletal 8
UniProt Synonym Protein Names
Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8
UniProt Synonym Gene Names
NCBI Summary for CYK8
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Comments for CYK8
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Research Articles on CYK8
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Pathways associated with anti-CYK8 antibody
Diseases associated with anti-CYK8 antibody
Organs/Tissues associated with anti-CYK8 antibody
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