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anti-ARHGDIB antibody :: Mouse anti-Human D4-GDI Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS601449 anti-ARHGDIB antibody
Unit / Price
0.1 mg  /  $730 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

D4-GDI (ARHGDIB), Monoclonal Antibody

 Also Known As   

D4-GDI (GDP Dissociation Inhibitor, Rho GDP-dissociation Inhibitor 2, Rho GDI 2, Ly-GDI, Rho-GDI beta, ARHGDIB, GDIA2, GDID4, RAP1GN1) (Biotin)

 Product Synonym Names    Anti -D4-GDI (GDP Dissociation Inhibitor, Rho GDP-dissociation Inhibitor 2, Rho GDI 2, Ly-GDI, Rho-GDI beta, ARHGDIB, GDIA2, GDID4, RAP1GN1) (Biotin)
 Product Gene Name   

anti-ARHGDIB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 5; NC_007303.4 (101692667..101711560)
 3D Structure    ModBase 3D Structure for Q9TU03
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 Clonality    Monoclonal
 Isotype    IgG1,k
 Clone Number    8J1255
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human D4-GDI at ~28kD.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.02% sodium azide. Labeled with Biotin.
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 Immunogen    Synthetic peptide corresponding to human D4-GDI.
 Positive Control    Whole cell lysate from Daudi or Jurkat cells
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
 Other Notes    Small volumes of anti-ARHGDIB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ARHGDIB antibody

   D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras-related Rho family of GTPases. Since the Rho GTPases promote cytoskeletal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block through its cleavage is important for inducing apoptosis. Caspase-3 cleaves the 28kD mature form of D4-GDI to give a 23kD and 5kD size fragment. The 23kD fragment then translocates to the nucleus. The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. Activation of the Jun N-terminal kinase, a regulator of apoptosis, may be one of the mechanisms.
 Product Categories/Family for anti-ARHGDIB antibody    Antibodies; Abs to GTPase, Rab, Ras, Rho Proteins
 Applications Tested/Suitable for anti-ARHGDIB antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-ARHGDIB antibody    Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1-2ug/ml
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NCBI/Uniprot data below describe general gene information for ARHGDIB. It may not necessarily be applicable to this product.
 NCBI GI #    6007524
 NCBI GeneID    327676
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 UniProt Primary Accession #    Q9TU03 [Other Products]
 UniProt Secondary Accession #    Q3ZCK4 [Other Products]
 UniProt Related Accession #    Q9TU03 [Other Products]
 Molecular Weight    22,794 Da [Similar Products]
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 NCBI Official Full Name    D4-GDP-dissociation inhibitor
 NCBI Official Symbol    ARHGDIB [Similar Products]
 NCBI Protein Information    rho GDP-dissociation inhibitor 2; D4-GDI; ly-GDI; rho GDI 2; rho-GDI beta; D4-GDP-dissociation inhibitor
 UniProt Protein Name    Rho GDP-dissociation inhibitor 2
 UniProt Synonym Protein Names   
D4-GDP-dissociation inhibitor; D4-GDI; Ly-GDI; Rho-GDI beta
 Protein Family    Rho GDP-dissociation inhibitor
 UniProt Gene Name    ARHGDIB [Similar Products]
 UniProt Synonym Gene Names    GDID4 [Similar Products]
 UniProt Entry Name    GDIR2_BOVIN
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 UniProt Comments for ARHGDIB    Function: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

Subcellular location: Cytoplasm.

Sequence similarities: Belongs to the Rho GDI family.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ARHGDIB antibodyDiseases associated with anti-ARHGDIB antibody
 Products by Pathway  Pathway Diagram
 FAS Pathway And Stress Induction Of HSP Regulation antibodies  FAS Pathway And Stress Induction Of HSP Regulation Diagram
 G13 Signaling Pathway antibodies  G13 Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Signaling By Rho GTPases Pathway antibodies  Signaling By Rho GTPases Pathway Diagram
 Vasopressin-regulated Water Reabsorption Pathway antibodies  Vasopressin-regulated Water Reabsorption Pathway Diagram
 Vasopressin-regulated Water Reabsorption Pathway antibodies  Vasopressin-regulated Water Reabsorption Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >28 publications with ARHGDIB and Neoplasms
 Female Urogenital Diseases Antibodies  >10 publications with ARHGDIB and Female Urogenital Diseases
 Carcinoma Antibodies  >10 publications with ARHGDIB and Carcinoma
 Urogenital Neoplasms Antibodies  >10 publications with ARHGDIB and Urogenital Neoplasms
 Neoplasm Invasiveness Antibodies  >9 publications with ARHGDIB and Neoplasm Invasiveness
 Male Urogenital Diseases Antibodies  >9 publications with ARHGDIB and Male Urogenital Diseases
 Lung Neoplasms Antibodies  >9 publications with ARHGDIB and Lung Neoplasms
 Urinary Bladder Neoplasms Antibodies  >9 publications with ARHGDIB and Urinary Bladder Neoplasms
 Lung Diseases Antibodies  >8 publications with ARHGDIB and Lung Diseases
 Skin Diseases Antibodies  >6 publications with ARHGDIB and Skin Diseases
Organs/Tissues associated with anti-ARHGDIB antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >10 publications with ARHGDIB and Lung
 Ovary Antibodies  >1 publications with ARHGDIB and Ovary
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