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anti-DAZAP1 antibody :: Mouse anti-Human DAZAP1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120505
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DAZAP1, Monoclonal Antibody

 Also Known As   

Mouse monoclonal antibody Anti-Human DAZAP1

 Product Synonym Names    Homo sapiens DAZ associated protein 1 (DAZAP1), transcript variant 1, mRNA.; MGC19907
 Product Gene Name   

anti-DAZAP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607430
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    2242C2a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-DAZAP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DAZAP1 antibody

   In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene. [provided by RefSeq][NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-DAZAP1 antibody   

Dot Blot (DB)

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 Quality Control of anti-DAZAP1 antibody    Western blot analysis of immunized recombinant protein, using anti-DAZAP1 monoclonal antibody.
anti-DAZAP1 antibody Quality Control image
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 Quality Control #2 of anti-DAZAP1 antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-DAZAP1 antibody Quality Control #2 image
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 Immunocytochemistry (ICC) of anti-DAZAP1 antibody    Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-DAZAP1 mAb. [LotNo. 2242C2a-1]
anti-DAZAP1 antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for DAZAP1. It may not necessarily be applicable to this product.
 NCBI GI #    537361060
 NCBI GeneID    26528
 NCBI Accession #    NP_733829.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_170711 [Other Products]
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 UniProt Secondary Accession #    Q96MJ3; Q9NRR9 [Other Products]
 UniProt Related Accession #    Q96EP5 [Other Products]
 Molecular Weight    40,530 Da
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 NCBI Official Full Name    Homo sapiens DAZ associated protein 1 (DAZAP1), transcript variant 1, mRNA
 NCBI Official Synonym Full Names    DAZ associated protein 1
 NCBI Official Symbol    DAZAP1 [Similar Products]
 NCBI Protein Information    DAZ-associated protein 1; deleted in azoospermia-associated protein 1
 UniProt Protein Name    DAZ-associated protein 1
 UniProt Synonym Protein Names   
Deleted in azoospermia-associated protein 1
 Protein Family    DAZ-associated protein
 UniProt Gene Name    DAZAP1 [Similar Products]
 UniProt Entry Name    DAZP1_HUMAN
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 NCBI Summary for DAZAP1    In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DAZAP1    DAZAP1: a ubiquitous RNA-binding protein highly expressed in the human and the mouse testes. In round spermatids, it localizes mainly in the nuclei, whereas in elongated spermatids, it localizes to the cytoplasm. Expressed at lower level in thymus and weakly expressed in heart, liver, brain, placenta, lung, skeletal muscle, kidney and pancreas. Fusion proteins between DAZAP1 and MEF2D have been observed in the TS-2 acute lymphoblastic leukemia (ALL) cell line. Two alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; RNA-binding

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: RNA binding; nucleotide binding

Biological Process: positive regulation of nuclear mRNA splicing, via spliceosome; cell proliferation; spermatogenesis; cell differentiation; maternal placenta development
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 Research Articles on DAZAP1    1. this study reports the mapping of a 42-amino acid segment (N42) at the N-terminus of DAZAP1 that is both necessary and sufficient for its transcription-dependent nuclear localization.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DAZAP1 antibodyPathways associated with anti-DAZAP1 antibody
 Reference Product  PubMed Publications
 DAZ1 antibody  >4 publications with DAZAP1 and DAZ1
 DAZL antibody  >4 publications with DAZAP1 and DAZL
 DAZAP2 antibody  >2 publications with DAZAP1 and DAZAP2
 Products by Pathway  Pathway Diagram
 MRNA Surveillance Pathway antibodies  MRNA Surveillance Pathway Diagram
 MRNA Surveillance Pathway antibodies  MRNA Surveillance Pathway Diagram
Diseases associated with anti-DAZAP1 antibodyOrgans/Tissues associated with anti-DAZAP1 antibody
 Disease Name  Pubmed Publications
 Infertility, Male Antibodies  >4 publications with DAZAP1 and Infertility, Male
 Chromosome Aberrations Antibodies  >3 publications with DAZAP1 and Chromosome Aberrations
 Neurobehavioral Manifestations Antibodies  >1 publications with DAZAP1 and Neurobehavioral Manifestations
 Infertility, Female Antibodies  >1 publications with DAZAP1 and Infertility, Female
 Learning Disorders Antibodies  >1 publications with DAZAP1 and Learning Disorders
 Necrosis Antibodies  >1 publications with DAZAP1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >9 publications with DAZAP1 and Testis
 Brain Antibodies  >2 publications with DAZAP1 and Brain
 Bone Marrow Antibodies  >1 publications with DAZAP1 and Bone Marrow
 Bone Antibodies  >1 publications with DAZAP1 and Bone
 Kidney Antibodies  >1 publications with DAZAP1 and Kidney
 Ovary Antibodies  >1 publications with DAZAP1 and Ovary
 Embryonic Tissue Antibodies  >1 publications with DAZAP1 and Embryonic Tissue
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