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anti-DCK antibody :: Mouse anti-Human DCK Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120196
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DCK, Monoclonal Antibody

 Also Known As   

Mouse monoclonal antibody Anti-Human DCK

 Product Synonym Names    Homo sapiens deoxycytidine kinase (DCK), mRNA; MGC117410;MGC138632
 Product Gene Name   

anti-DCK antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    125450
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    2243C2
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-DCK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-DCK antibody

   Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-DCK antibody   

Dot Blot (DB)

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 Quality Control of anti-DCK antibody    Western blot analysis of immunized recombinant protein, using anti-DCK monoclonal antibody.
anti-DCK antibody Quality Control image
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 Quality Control #2 of anti-DCK antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-DCK antibody Quality Control #2 image
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NCBI/Uniprot data below describe general gene information for DCK. It may not necessarily be applicable to this product.
 NCBI GI #    194578889
 NCBI GeneID    1633
 NCBI Accession #    NP_000779.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000788 [Other Products]
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 UniProt Secondary Accession #    Q5TZY7; Q6FI11; B2R8V6 [Other Products]
 UniProt Related Accession #    P27707 [Other Products]
 Molecular Weight    30,519 Da
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 NCBI Official Full Name    Homo sapiens deoxycytidine kinase (DCK), mRNA
 NCBI Official Synonym Full Names    deoxycytidine kinase
 NCBI Official Symbol    DCK [Similar Products]
 NCBI Protein Information    deoxycytidine kinase; deoxynucleoside kinase
 UniProt Protein Name    Deoxycytidine kinase
 UniProt Gene Name    DCK [Similar Products]
 UniProt Entry Name    DCK_HUMAN
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 NCBI Summary for DCK    Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DCK    DCK: Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. Belongs to the DCK/DGK family.

Protein type: Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Kinase, other; EC 2.7.1.74

Chromosomal Location of Human Ortholog: 4q13.3-q21.1

Cellular Component: nucleus; cytosol

Molecular Function: protein homodimerization activity; nucleoside kinase activity; deoxycytidine kinase activity; drug binding; ATP binding

Biological Process: pyrimidine base metabolic process; pyrimidine nucleotide metabolic process; nucleotide biosynthetic process; nucleobase, nucleoside and nucleotide metabolic process; pyrimidine nucleoside salvage; phosphorylation; purine salvage; purine base metabolic process; deoxyribonucleoside monophosphate biosynthetic process
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 Research Articles on DCK    1. induction after hypoxia plays a role in the progression of pulmonary fibrosis by contributing to alveolar epithelial cell proliferation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DCK antibodyPathways associated with anti-DCK antibody
 Reference Product  PubMed Publications
 CDA antibody  >74 publications with DCK and CDA
 ADA antibody  >10 publications with DCK and ADA
 NT5C2 antibody  >8 publications with DCK and NT5C2
 PNP antibody  >8 publications with DCK and PNP
 DCTD antibody  >7 publications with DCK and DCTD
 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Salvage Pathway antibodies  Purine Salvage Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
Diseases associated with anti-DCK antibodyOrgans/Tissues associated with anti-DCK antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >60 publications with DCK and Carcinoma
 Pancreatic Neoplasms Antibodies  >39 publications with DCK and Pancreatic Neoplasms
 Lung Neoplasms Antibodies  >29 publications with DCK and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >27 publications with DCK and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >15 publications with DCK and Disease Models, Animal
 Ovarian Neoplasms Antibodies  >11 publications with DCK and Ovarian Neoplasms
 Carcinoma, Squamous Cell Antibodies  >9 publications with DCK and Carcinoma, Squamous Cell
 Breast Neoplasms Antibodies  >7 publications with DCK and Breast Neoplasms
 Liver Neoplasms Antibodies  >5 publications with DCK and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >4 publications with DCK and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >108 publications with DCK and Blood
 Lung Antibodies  >42 publications with DCK and Lung
 Brain Antibodies  >26 publications with DCK and Brain
 Liver Antibodies  >22 publications with DCK and Liver
 Bone Marrow Antibodies  >21 publications with DCK and Bone Marrow
 Spleen Antibodies  >15 publications with DCK and Spleen
 Pancreas Antibodies  >9 publications with DCK and Pancreas
 Lymph Antibodies  >8 publications with DCK and Lymph
 Lymph Node Antibodies  >8 publications with DCK and Lymph Node
 Thymus Antibodies  >7 publications with DCK and Thymus
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