Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow DDX48 rightarrow Monoclonal DDX48  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Interleukin-8 (IL8) Recombinant Protein
 • Synaptosomal Associated Protein 25kDa (SNAP25) ELISA Kit
 • Cluster of Differentiation 226 (CD226) ELISA Kit
 • MASP2 Antibody
 • Albumin (ALB) Antibody
 • Fibronectin (FN1) ELISA Kit
 • N-Telopeptide Of Type I Collagen (NTXI) (NTXI ) Small Molecule
 • AAR2 siRNA
 • Heparan Sulphate Proteoglycan (HSPG) ELISA Kit
 • Glycogen synthase kinase-3 beta (GSK3B) Recombinant Protein
 • Renin receptor (Atp6ap2) Recombinant Protein
 • 14-3-3, gamma (YWHAG) Antibody
 • v-myc myelocytomatosis viral oncogene homolog 1, lung carcin... ELISA Kit
 • glutaminase (GLS2) Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-DDX48 antibody :: Mouse anti-Human DDX48 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120199
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DDX48, Monoclonal Antibody

 Also Known As   

Mouse monoclonal antibody Anti-Human DDX48

 Product Synonym Names    Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 48 (DDX48); EIF4A3;NUK-34; hNMP265; KIAA0111;MGC10862; eIF4AIII
 Product Gene Name   

anti-DDX48 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    268305
Section Bar
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    2256C1
 Host    Mouse
 Species Reactivity    Human
Section Bar
 Concentration    100 ug/ml (1.0 ml) (lot specific)
Section Bar
 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
Section Bar
 Other Notes    Small volumes of anti-DDX48 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-DDX48 antibody

   This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family. [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-DDX48 antibody   

Dot Blot (DB)

Section Bar
 Quality Control of anti-DDX48 antibody    Western blot analysis of immunized recombinant protein, using anti-DDX48 monoclonal antibody.
anti-DDX48 antibody Quality Control image
Section Bar
 Quality Control #2 of anti-DDX48 antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-DDX48 antibody Quality Control #2 image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for DDX48. It may not necessarily be applicable to this product.
 NCBI GI #    288915541
 NCBI GeneID    9775
 NCBI Accession #    NP_055555.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_014740 [Other Products]
Section Bar
 UniProt Secondary Accession #    Q15033; Q6IBQ2; Q96A18 [Other Products]
 UniProt Related Accession #    P38919 [Other Products]
 Molecular Weight    46,871 Da
Table BarTOPTable Bar
 NCBI Official Full Name    Homo sapiens eukaryotic translation initiation factor 4A3 (EIF4A3), mRNA
 NCBI Official Synonym Full Names    eukaryotic translation initiation factor 4A3
 NCBI Official Symbol    EIF4A3 [Similar Products]
 NCBI Official Synonym Symbols   
RCPS; DDX48; MUK34; NUK34; NMP265; eIF4AIII
[Similar Products]
 NCBI Protein Information    eukaryotic initiation factor 4A-III; ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-3; DEAD (Asp-Glu-Ala-Asp) box polypeptide 48; DEAD box protein 48; NMP 265; eIF-4A-III; eIF4A-III; eukaryotic initiation factor 4A-like NUK-34; eukaryotic translation initiation factor 4A, isoform 3; hNMP 265; nuclear matrix protein 265
 UniProt Gene Name    EIF4A3 [Similar Products]
 UniProt Entry Name    IF4A3_HUMAN
Section Bar
 NCBI Summary for DDX48    This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for DDX48    DDX48: ATP-dependent RNA helicase. Component of a splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Constitutes at least part of the platform anchoring other EJC proteins to spliced mRNAs. Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH/RBM8A heterodimer, thereby trapping the ATP- bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH/RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Belongs to the DEAD box helicase family. eIF4A subfamily.

Protein type: Spliceosome; Helicase; RNA-binding; EC 3.6.4.13; RNA splicing

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: nucleoplasm; membrane; cytoplasm; nuclear speck; cytosol

Molecular Function: mRNA binding; protein binding; ATP binding; poly(A) binding; ATP-dependent RNA helicase activity

Biological Process: nuclear mRNA splicing, via spliceosome; poly(A) tail shortening; mRNA transport; positive regulation of translation; negative regulation of translation; cytokine and chemokine mediated signaling pathway; mRNA catabolic process, nonsense-mediated decay; gene expression; embryonic cranial skeleton morphogenesis; rRNA processing; mRNA catabolic process, deadenylation-dependent decay

Disease: Robin Sequence With Cleft Mandible And Limb Anomalies
Table BarTOPTable Bar
 Research Articles on DDX48    1. EIF4A3 is a gene involved in RNA metabolism, plays a role in mandible, laryngeal, and limb morphogenesis. Richieri-Costa-Pereira syndrome is caused by mutations in EIF4A3.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-DDX48 antibodyPathways associated with anti-DDX48 antibody
 Reference Product  PubMed Publications
 MAGOH antibody  >11 publications with DDX48 and MAGOH
 RBM8A antibody  >6 publications with DDX48 and RBM8A
 UPF1 antibody  >5 publications with DDX48 and UPF1
 UPF3B antibody  >5 publications with DDX48 and UPF3B
 RNPS1 antibody  >3 publications with DDX48 and RNPS1
 CWC22 antibody  >2 publications with DDX48 and CWC22
 CASC3 antibody  >2 publications with DDX48 and CASC3
 SMG6 antibody  >1 publications with DDX48 and SMG6
 UPF3A antibody  >1 publications with DDX48 and UPF3A
 Products by Pathway  Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Deadenylation Of MRNA Pathway antibodies  Deadenylation Of MRNA Pathway Diagram
 Deadenylation-dependent MRNA Decay Pathway antibodies  Deadenylation-dependent MRNA Decay Pathway Diagram
 Exon Junction Complex (EJC) Pathway antibodies  Exon Junction Complex (EJC) Pathway Diagram
 Exon Junction Complex (EJC) Pathway antibodies  Exon Junction Complex (EJC) Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 ISG15 Antiviral Mechanism Pathway antibodies  ISG15 Antiviral Mechanism Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
Diseases associated with anti-DDX48 antibodyOrgans/Tissues associated with anti-DDX48 antibody
 Disease Name  Pubmed Publications
 Thrombocytopenia Antibodies  >1 publications with DDX48 and Thrombocytopenia
 Craniofacial Abnormalities Antibodies  >1 publications with DDX48 and Craniofacial Abnormalities
 Carcinoma, Hepatocellular Antibodies  >1 publications with DDX48 and Carcinoma, Hepatocellular
 Memory Disorders Antibodies  >1 publications with DDX48 and Memory Disorders
 Neurobehavioral Manifestations Antibodies  >1 publications with DDX48 and Neurobehavioral Manifestations
 Learning Disorders Antibodies  >1 publications with DDX48 and Learning Disorders
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with DDX48 and Blood
 Muscle Antibodies  >2 publications with DDX48 and Muscle
 Liver Antibodies  >2 publications with DDX48 and Liver
 Brain Antibodies  >2 publications with DDX48 and Brain
 Nerve Antibodies  >1 publications with DDX48 and Nerve
 Connective Tissue Antibodies  >1 publications with DDX48 and Connective Tissue
 Bone Antibodies  >1 publications with DDX48 and Bone
 Embryonic Tissue Antibodies  >1 publications with DDX48 and Embryonic Tissue
 Lung Antibodies  >1 publications with DDX48 and Lung
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions