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anti-DECTIN-1 antibody :: Mouse DECTIN-1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS219379
Unit / Price
0.2 mg  /  $430 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DECTIN-1, Monoclonal Antibody

 Also Known As   

MOUSE ANTI HUMAN DECTIN-1

 Product Gene Name   

anti-DECTIN-1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606264
 3D Structure    ModBase 3D Structure for Q9BXN2
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    BD6
 Host    Mouse
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
Preparation
 Immunogen    NIH3T3 cells expressing full length Beta-glucan receptor
Fusion Partners
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-DECTIN-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DECTIN-1 antibody

   Mouse anti Human Dectin-1 antibody, clone BD6 recognizes human Dectin-1, also known as beta-glucan receptor (betaGR), a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans, glucose polymers that form cell-wall components or exopolymers of yeasts, fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial, yeast, viral and protozoan infections, as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells. Human Dectin-1 has two major (betaGR-A and betaGR-B) and several minor isoforms. betaGR-A and betaGR-B differs by the presence and absence, respectively, of a stalk region. Mouse anti Human Dectin-1 antibody, clone BD6 recognizes betaGR-A only.
 Applications Tested/Suitable for anti-DECTIN-1 antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-DECTIN-1 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Flow Cytometry: Minimum Dilution: 1/25; Maximum Dilution: 1/200
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 Testing Data of anti-DECTIN-1 antibody    Staining of human peripheral blood granulocytes with Mouse anti Human Dectin-1:Alexa Fluor ?647 (MBS219379A647)
anti-DECTIN-1 antibody Testing Data image
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 Testing Data of anti-DECTIN-1 antibody    Staining of human peripheral blood granulocytes with Mouse anti Human Dectin-1:RPE (MBS219707)
anti-DECTIN-1 antibody Testing Data image
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 Testing Data of anti-DECTIN-1 antibody    Staining of human peripheral blood granulocytes with Mouse anti Human Dectin-1:Alexa Fluor 488 (MBS219379A488)
anti-DECTIN-1 antibody Testing Data image
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 Testing Data of anti-DECTIN-1 antibody    Staining of human peripheral blood monocytes with Mouse anti Human Dectin-1:FITC (MBS219729)
anti-DECTIN-1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for DECTIN-1. It may not necessarily be applicable to this product.
 NCBI GI #    13384604
 NCBI GeneID    64581
 NCBI Accession #    NP_072092.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_022570.4 [Other Products]
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 UniProt Primary Accession #    Q9BXN2 [Other Products]
 UniProt Secondary Accession #    Q6IPS7; Q96D32; Q96DR9; Q96LD3; Q96PA4; Q96PA5; Q96PA6; B2R861; B7Z494; B7Z5A9; B7Z5B9 [Other Products]
 UniProt Related Accession #    Q9BXN2 [Other Products]
 Molecular Weight    13,138 Da
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 NCBI Official Full Name    C-type lectin domain family 7 member A isoform b
 NCBI Official Synonym Full Names    C-type lectin domain family 7, member A
 NCBI Official Symbol    CLEC7A [Similar Products]
 NCBI Official Synonym Symbols   
BGR; CANDF4; DECTIN1; CLECSF12
[Similar Products]
 NCBI Protein Information    C-type lectin domain family 7 member A; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; C-type lectin superfamily member 12; DC-associated C-type lectin 1; beta-glucan receptor; dectin-1; dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; lectin-like receptor 1
 UniProt Protein Name    C-type lectin domain family 7 member A
 UniProt Synonym Protein Names   
Beta-glucan receptor; C-type lectin superfamily member 12; Dendritic cell-associated C-type lectin 1; DC-associated C-type lectin 1; Dectin-1
 UniProt Gene Name    CLEC7A [Similar Products]
 UniProt Synonym Gene Names    BGR; CLECSF12; DECTIN1; DC-associated C-type lectin 1; Dectin-1 [Similar Products]
 UniProt Entry Name    CLC7A_HUMAN
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 NCBI Summary for DECTIN-1    This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DECTIN-1    dectin-1: Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Up-regulated during differentiation from monocytes into dendritic cells. Isoform 5 interacts with RANBP9. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.2

Cellular Component: cytoplasm; integral to membrane; plasma membrane

Molecular Function: metal ion binding; carbohydrate binding; MHC protein binding; pattern recognition receptor activity

Biological Process: T cell activation; innate immune response; phagocytosis, recognition; cell recognition; carbohydrate mediated signaling; pattern recognition receptor signaling pathway; inflammatory response; defense response to protozoan

Disease: Candidiasis, Familial, 4; Aspergillosis, Susceptibility To
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 Research Articles on DECTIN-1    1. CARD9 regulates H-Ras activation by linking Ras-GRF1 to H-Ras, which mediates Dectin-1-induced extracellular signal-regulated protein kinase (ERK) activation and proinflammatory responses when stimulated by their ligands.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-DECTIN-1 antibodyDiseases associated with anti-DECTIN-1 antibody
 Products by Pathway  Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >14 publications with DECTIN-1 and Inflammation
 Necrosis Antibodies  >5 publications with DECTIN-1 and Necrosis
 Lung Diseases Antibodies  >2 publications with DECTIN-1 and Lung Diseases
 Liver Diseases Antibodies  >2 publications with DECTIN-1 and Liver Diseases
 Cardiovascular Diseases Antibodies  >1 publications with DECTIN-1 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >1 publications with DECTIN-1 and Atherosclerosis
 Liver Cirrhosis Antibodies  >1 publications with DECTIN-1 and Liver Cirrhosis
 Non-alcoholic Fatty Liver Disease Antibodies  >1 publications with DECTIN-1 and Non-alcoholic Fatty Liver Disease
 Fatty Liver Antibodies  >1 publications with DECTIN-1 and Fatty Liver
 Disease Models, Animal Antibodies  >1 publications with DECTIN-1 and Disease Models, Animal
Organs/Tissues associated with anti-DECTIN-1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >25 publications with DECTIN-1 and Blood
 Lung Antibodies  >6 publications with DECTIN-1 and Lung
 Intestine Antibodies  >3 publications with DECTIN-1 and Intestine
 Bone Marrow Antibodies  >3 publications with DECTIN-1 and Bone Marrow
 Spleen Antibodies  >2 publications with DECTIN-1 and Spleen
 Vascular Antibodies  >1 publications with DECTIN-1 and Vascular
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