Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow Dll4 rightarrow Monoclonal Dll4  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Melatonin, MT ELISA Kit
 • ghrelin-obestatin prepropeptide (GHRL) ELISA Kit
 • Heat Shock Protein 90 Alpha (HSP90 ) Recombinant Protein
 • Rat anti Mouse IgG1 Kappa Light Chain Secondary Antibody
 • Heme oxygenase 1 (HMOX1) Recombinant Protein
 • TROPONIN I (TNNI3) Antibody
 • COL7A1 Antibody
 • gamma-aminobutyric acid (GABA) A receptor, beta 2 (GABRB2) ELISA Kit
 • TERT Antibody
 • apolipoprotein E (APOE) ELISA Kit
 • ESET - SETDB1 Antibody
 • Estradiol Antibody
 • S100 Calcium Binding Protein A12 (S100A12) Antibody
 • Apolipoprotein A2 (APOA2) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-Dll4 antibody :: Hamster DELTA-LIKE PROTEIN 4 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS219861
Unit / Price
0.25 mg  /  $370 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DELTA-LIKE PROTEIN 4 (Dll4), Monoclonal Antibody

 Also Known As   

HAMSTER ANTI MOUSE DELTA-LIKE PROTEIN 4

 Product Gene Name   

anti-Dll4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 3D Structure    ModBase 3D Structure for Q9JI71
 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    HMD4-2
 Host    Hamster
Section Bar
 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0mg/ml (lot specific)
Section Bar
 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
Preparation
 Immunogen    Recombinant mouse DLL4.
Histology Positive Control Tissue
 Target Species    Mouse
Section Bar
 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-Dll4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-Dll4 antibody

   Hamster anti Mouse Delta-Like Protein 4 antibody, clone HMD4-2 specifically recognizes mouse Delta-like protein 4 (DLL4), one of the five major ligands of the Notch signalling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4. The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell haematopoiesis, thymic T-cell development, and both tumour progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta like-1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. DLL4 is expressed by vascular endothelium, and plays a vital role in embryonic vascular development. DLL4 signalling has been shown to play a role in the angiogenesis of clear-cell renal tumours, and pancreatic, bladder and colonic cancer. Studies have shown that DLL4 expression in endothelium cells, can be up-regulated by vascular endothelial growth factor (VEGF) and basic-FGF, and by HIF1 alpha, and that blockade of DLL4 inhibits tumour growth by promoting non-productive angiogenesis. Hamster anti Mouse Delta-Like Protein 4 ant
 Applications Tested/Suitable for anti-Dll4 antibody   

Immunohistology Frozen, Flow cytometry (FC/FACS), Functional Assays (FN), Immunohistology Paraffin*

 Application Notes for anti-Dll4 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Immunohistology - Paraffin: Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Section Bar
 Testing Data of anti-Dll4 antibody    Mouse Delta like protein 4 transfected cells stained with Hamster anti Mouse Delta Like Protein 4
anti-Dll4 antibody Testing Data image
Section Bar
 Testing Data of anti-Dll4 antibody    Mouse Delta like protein 4 transfected cells stained with Hamster anti Mouse Delta Like Protein 4:RPE (MBS219861PE)
anti-Dll4 antibody Testing Data image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for Dll4. It may not necessarily be applicable to this product.
 NCBI GI #    244799228
 NCBI GeneID    54485
 NCBI Accession #    NP_062327.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_019454.3 [Other Products]
Section Bar
 UniProt Primary Accession #    Q9JI71 [Other Products]
 UniProt Secondary Accession #    Q9DBU9; Q9JHZ7 [Other Products]
 UniProt Related Accession #    Q9JI71 [Other Products]
 Molecular Weight    74,991 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    delta-like protein 4
 NCBI Official Synonym Full Names    delta-like 4 (Drosophila)
 NCBI Official Symbol    Dll4 [Similar Products]
 NCBI Official Synonym Symbols   
Delta4
[Similar Products]
 NCBI Protein Information    delta-like protein 4; drosophila Delta homolog 4
 UniProt Protein Name    Delta-like protein 4
 UniProt Synonym Protein Names   
Drosophila Delta homolog 4; Delta4
 Protein Family    Delta-like protein
 UniProt Gene Name    Dll4 [Similar Products]
 UniProt Synonym Gene Names    Delta4 [Similar Products]
 UniProt Entry Name    DLL4_MOUSE
Section Bar
 UniProt Comments for Dll4    DLL4: Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4. Binds to Notch-1 and Notch-4. Expressed in vascular endothelium.

Protein type: Membrane protein, integral; Cell development/differentiation

Cellular Component: membrane; integral to plasma membrane; integral to membrane

Molecular Function: protein binding; calcium ion binding; Notch binding

Biological Process: nervous system development; Notch signaling pathway; multicellular organismal development; response to stimulus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of blood vessel endothelial cell migration; patterning of blood vessels; negative regulation of cell proliferation; regulation of neurogenesis; visual perception; cell communication; blood vessel remodeling; angiogenesis; cell differentiation
Table BarTOPTable Bar
 Research Articles on Dll4    1. Demonstrate that the action of IFNgamma on endothelial cellss, but not other cells, is highly effective for tumour angiostasis, which involves down-regulating Dll4.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Pathways associated with anti-Dll4 antibodyDiseases associated with anti-Dll4 antibody
 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies  Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 FBXW7 Mutants And NOTCH1 In Cancer Pathway antibodies  FBXW7 Mutants And NOTCH1 In Cancer Pathway Diagram
 NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway antibodies  NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Neovascularization, Pathologic Antibodies  >93 publications with Dll4 and Neovascularization, Pathologic
 Disease Models, Animal Antibodies  >36 publications with Dll4 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >25 publications with Dll4 and Neoplasms, Experimental
 Death Antibodies  >18 publications with Dll4 and Death
 Inflammation Antibodies  >16 publications with Dll4 and Inflammation
 Breast Neoplasms Antibodies  >15 publications with Dll4 and Breast Neoplasms
 Lung Diseases Antibodies  >14 publications with Dll4 and Lung Diseases
 Lung Neoplasms Antibodies  >13 publications with Dll4 and Lung Neoplasms
 Hypertension Antibodies  >9 publications with Dll4 and Hypertension
 Kidney Diseases Antibodies  >9 publications with Dll4 and Kidney Diseases
Organs/Tissues associated with anti-Dll4 antibody
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >47 publications with Dll4 and Embryonic Tissue
 Brain Antibodies  >34 publications with Dll4 and Brain
 Lung Antibodies  >30 publications with Dll4 and Lung
 Thymus Antibodies  >28 publications with Dll4 and Thymus
 Eye Antibodies  >26 publications with Dll4 and Eye
 Heart Antibodies  >21 publications with Dll4 and Heart
 Skin Antibodies  >15 publications with Dll4 and Skin
 Liver Antibodies  >15 publications with Dll4 and Liver
 Intestine Antibodies  >12 publications with Dll4 and Intestine
 Spleen Antibodies  >12 publications with Dll4 and Spleen
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions