NP_001336
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
diacylglycerol kinase alpha
NCBI Official Synonym Full Names
diacylglycerol kinase, alpha 80kDa
NCBI Protein Information
diacylglycerol kinase alpha
UniProt Protein Name
Diacylglycerol kinase alpha
UniProt Synonym Protein Names
80 kDa diacylglycerol kinase; Diglyceride kinase alpha; DGK-alpha
UniProt Synonym Gene Names
UniProt Entry Name
DGKA_HUMAN
NCBI Summary for DGKA
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for DGKA
DGKA: Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. Monomer. Lymphocytes and oligodendroglial cells. Stimulated by calcium and phosphatidylserine. Phosphorylated by protein kinase C. Belongs to the eukaryotic diacylglycerol kinase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Lipid Metabolism - glycerolipid; EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerophospholipid
Chromosomal Location of Human Ortholog: 12q13.3
Cellular Component: membrane; plasma membrane; cytosol
Molecular Function: phospholipid binding; calcium ion binding; diacylglycerol kinase activity; ATP binding; NAD+ kinase activity
Biological Process: platelet activation; protein kinase C activation; blood coagulation; phosphorylation
Research Articles on DGKA
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Pathways associated with anti-DGKA antibody
Organs/Tissues associated with anti-DGKA antibody
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