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anti-DHX9 antibody :: Mouse anti-Human DHX9 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120267
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DHX9, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse monoclonal antibody Anti-Human DHX9

 Product Synonym Names    Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 9 (DHX9), transcript variant 1; LKP; RHA; DDX9; NDHII; NDH II
 Product Gene Name   

anti-DHX9 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603115
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    2274D5a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-DHX9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DHX9 antibody

   DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein with RNA helicase activity. It may participate in melting of DNA:RNA hybrids, such as those that occur during transcription, and may play a role in X-linked gene expression. It contains 2 copies of a double-stranded RNA-binding domain, a DEXH core domain and an RGG box. The RNA-binding domains and RGG box influence and regulate RNA helicase activity. [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-DHX9 antibody   

Dot Blot (DB)

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 Quality Control of anti-DHX9 antibody    Western blot analysis of immunized recombinant protein, using anti-DHX9 monoclonal antibody.
anti-DHX9 antibody Quality Control image
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 Quality Control #2 of anti-DHX9 antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-DHX9 antibody Quality Control #2 image
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NCBI/Uniprot data below describe general gene information for DHX9. It may not necessarily be applicable to this product.
 NCBI GI #    289063428
 NCBI GeneID    1660
 NCBI Accession #    NP_001348.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001357 [Other Products]
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 UniProt Secondary Accession #    Q05CI5; Q12803; Q32Q22; Q5VY62; Q6PD69; Q99556; B2RNV4 [Other Products]
 UniProt Related Accession #    Q08211 [Other Products]
 Molecular Weight    24,336 Da
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 NCBI Official Full Name    Homo sapiens DEAH (Asp-Glu-Ala-His) box helicase 9 (DHX9), transcript variant 1, mRNA
 NCBI Official Synonym Full Names    DEAH (Asp-Glu-Ala-His) box helicase 9
 NCBI Official Symbol    DHX9 [Similar Products]
 NCBI Official Synonym Symbols   
LKP; RHA; DDX9; NDH2; NDHII
[Similar Products]
 NCBI Protein Information    ATP-dependent RNA helicase A; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9; DEAH (Asp-Glu-Ala-His) box polypeptide 9; DEAH box protein 9; leukophysin; nuclear DNA helicase II
 UniProt Protein Name    ATP-dependent RNA helicase A
 UniProt Synonym Protein Names   
DEAH box protein 9; Leukophysin; LKP; Nuclear DNA helicase II; NDH II
 Protein Family    ATP-dependent RNA helicase
 UniProt Gene Name    DHX9 [Similar Products]
 UniProt Entry Name    DHX9_HUMAN
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 NCBI Summary for DHX9    This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.[provided by RefSeq, Feb 2010]
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 UniProt Comments for DHX9    DDX9: a helicase that unwinds double-stranded DNA and RNA in a 3' to 5' direction. Interacts with the RNA-induced silencing complex (RISC) in human cells and functions in RISC loading. Generates multiple secondary structures that influence RNA-binding proteins. Has a dsRNA binding motif at the N-terminus, RGG-box at the carboxyl terminus, and a bidirectional nuclear transport domain of 110 amino acids at the carboxyl terminus. May play a role in X-linked gene expression.

Protein type: Nucleolus; RNA processing; RNA splicing; Nuclear receptor co-regulator; EC 3.6.4.13; RNA-binding; Helicase; Spliceosome

Chromosomal Location of Human Ortholog: 1q25

Cellular Component: nucleoplasm; centrosome; membrane; cytoplasm; nucleolus; cytosol; nucleus; ribonucleoprotein complex

Molecular Function: ATP-dependent DNA helicase activity; protein binding; DNA binding; ATP binding; RNA helicase activity; ATP-dependent RNA helicase activity

Biological Process: circadian rhythm; osteoblast differentiation; nuclear mRNA splicing, via spliceosome; RNA processing; RNA splicing; positive regulation of interferon type I production; innate immune response; gene expression; DNA duplex unwinding
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 Research Articles on DHX9    1. OB-fold is involved in modulating HIV-1 RNA splicing in the context of some HIV-1 strains while it is dispensable for the activation of HIV-1 transcription.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DHX9 antibodyPathways associated with anti-DHX9 antibody
 Reference Product  PubMed Publications
 DDX5 antibody  >7 publications with DHX9 and DDX5
 WRN antibody  >3 publications with DHX9 and WRN
 HNRNPA2B1 antibody  >2 publications with DHX9 and HNRNPA2B1
 HNRNPK antibody  >1 publications with DHX9 and HNRNPK
 HNRNPC antibody  >1 publications with DHX9 and HNRNPC
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway antibodies  DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 MyD88 Cascade Initiated On Plasma Membrane Pathway antibodies  MyD88 Cascade Initiated On Plasma Membrane Pathway Diagram
 MyD88 Dependent Cascade Initiated On Endosome Pathway antibodies  MyD88 Dependent Cascade Initiated On Endosome Pathway Diagram
 MyD88-independent Cascade Pathway antibodies  MyD88-independent Cascade Pathway Diagram
 MyD88:Mal Cascade Initiated On Plasma Membrane Pathway antibodies  MyD88:Mal Cascade Initiated On Plasma Membrane Pathway Diagram
Diseases associated with anti-DHX9 antibodyOrgans/Tissues associated with anti-DHX9 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >4 publications with DHX9 and Breast Neoplasms
 Prostatic Neoplasms Antibodies  >2 publications with DHX9 and Prostatic Neoplasms
 Chromosome Aberrations Antibodies  >1 publications with DHX9 and Chromosome Aberrations
 Adenocarcinoma Antibodies  >1 publications with DHX9 and Adenocarcinoma
 Inflammation Antibodies  >1 publications with DHX9 and Inflammation
 Liver Diseases Antibodies  >1 publications with DHX9 and Liver Diseases
 Atrophy Antibodies  >1 publications with DHX9 and Atrophy
 Neoplasms, Experimental Antibodies  >1 publications with DHX9 and Neoplasms, Experimental
 Necrosis Antibodies  >1 publications with DHX9 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >10 publications with DHX9 and Blood
 Lung Antibodies  >3 publications with DHX9 and Lung
 Brain Antibodies  >3 publications with DHX9 and Brain
 Prostate Antibodies  >2 publications with DHX9 and Prostate
 Kidney Antibodies  >2 publications with DHX9 and Kidney
 Nerve Antibodies  >2 publications with DHX9 and Nerve
 Bone Antibodies  >2 publications with DHX9 and Bone
 Lymph Node Antibodies  >1 publications with DHX9 and Lymph Node
 Muscle Antibodies  >1 publications with DHX9 and Muscle
 Thymus Antibodies  >1 publications with DHX9 and Thymus
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