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anti-DKK1 antibody :: Mouse anti-Human DKK1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS850869
Testing Data
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DKK1, Monoclonal Antibody

 Also Known As   

DKK1 Antibody

 Product Synonym Names    SK; DKK-1;
 Product Gene Name   

anti-DKK1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605189
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 Clonality    Monoclonal
 Clone Number    2H2
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
 Concentration    100ug/100ul (lot specific)
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 Immunogen    Purified recombinant fragment of DKK1 expressed in E. Coli
 Species    Mouse IgG2b
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 Preparation and Storage    Store at 4 degree C. For long term storage, store at -20 degree C
 Other Notes    Small volumes of anti-DKK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-DKK1 antibody

   Background: DKK1. dickkopf homolog 1 (Xenopus laevis), also known as SK. Entrez Protein NP_036374. DKK1 is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
 Product Categories/Family for anti-DKK1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-DKK1 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-DKK1 antibody    WB: 1/500 - 1/2000, ELISA: Propose dilution 1/10000
Not yet tested in other applications. Determining optimal working dilutions by titration test.
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 Testing Data of anti-DKK1 antibody    Figure 1. Western blot analysis using DKK1 mouse mAb against HEK293 (1) and DKK1-hIgGFc transfected HEK293 cell lysate (2).
Figure 1.
anti-DKK1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for DKK1. It may not necessarily be applicable to this product.
 NCBI GI #    7110719
 NCBI GeneID    22943
 NCBI Accession #    NP_036374.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012242.2 [Other Products]
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 UniProt Secondary Accession #    B2RC19 [Other Products]
 UniProt Related Accession #    O94907 [Other Products]
 Molecular Weight    28.7kDa
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 NCBI Official Full Name    dickkopf-related protein 1
 NCBI Official Synonym Full Names    dickkopf WNT signaling pathway inhibitor 1
 NCBI Official Symbol    DKK1 [Similar Products]
 NCBI Official Synonym Symbols   
SK; DKK-1
[Similar Products]
 NCBI Protein Information    dickkopf-related protein 1; hDkk-1; dickkopf-1 like; dickkopf 1 homolog; dickkopf-like protein 1; dickkopf related protein-1
 UniProt Protein Name    Dickkopf-related protein 1
 UniProt Synonym Protein Names   
SK
 Protein Family    Dickkopf-related protein
 UniProt Gene Name    DKK1 [Similar Products]
 UniProt Synonym Gene Names    Dickkopf-1; Dkk-1; hDkk-1 [Similar Products]
 UniProt Entry Name    DKK1_HUMAN
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 NCBI Summary for DKK1    This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DKK1    DKK1: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Interacts with LRP6. Interacts (via the C-termianl Cys- rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt- mediated signaling. Placenta. Belongs to the dickkopf family.

Protein type: Inhibitor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q11.2

Cellular Component: extracellular space; early endosome membrane; extracellular region; plasma membrane

Molecular Function: signal transducer activity; protein binding; receptor antagonist activity; growth factor activity; low-density lipoprotein receptor binding

Biological Process: cellular morphogenesis during differentiation; negative regulation of skeletal muscle development; response to retinoic acid; negative regulation of Wnt receptor signaling pathway; regulation of receptor internalization; negative regulation of peptidyl-serine phosphorylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of BMP signaling pathway; hair follicle development; negative regulation of mesodermal cell fate specification; mesoderm formation; endoderm formation; forebrain development; regulation of endodermal cell fate specification; negative regulation of protein complex assembly; embryonic limb morphogenesis
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 Research Articles on DKK1    1. Serum functional DKK-1 levels showed an independent and negative correlation with radiographic severity of the disease in patients with ankylosing spondylitis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to DKK1 Antibody
 Catalog #  Product Name  Catalog #  Product Name
 MBS2046773  APC/CY7-Linked Polyclonal Antibody to Dickkopf Related Protein 1 (DKK1)  MBS2046784  HRP-Linked Monoclonal Antibody to Dickkopf Related Protein 1 (DKK1)
 MBS2009815  Recombinant Dickkopf Related Protein 1 (DKK1)  MBS2046777  APC-Linked Polyclonal Antibody to Dickkopf Related Protein 1 (DKK1)
 MBS2546459  Recombinant Human DKK1 / Dkk-1 Protein (His tag)  MBS1081620  Recombinant Mouse Dickkopf-related protein 1 (Dkk1)
 MBS395772  Dickkopf (Xenopus laevis) homolog 1 (DKK1)  MBS455798  Human Dickkopf Related Protein 1 (DKK1) ELISA Kit
 MBS2046776  PE-Linked Monoclonal Antibody to Dickkopf Related Protein 1 (DKK1)  MBS2046774  APC/CY7-Linked Monoclonal Antibody to Dickkopf Related Protein 1 (DKK1)
Products associated with anti-DKK1 antibodyPathways associated with anti-DKK1 antibody
 Reference Product  PubMed Publications
 CTNNB1 antibody  >479 publications with DKK1 and CTNNB1
 WNT3A antibody  >126 publications with DKK1 and WNT3A
 LRP5 antibody  >117 publications with DKK1 and LRP5
 LRP6 antibody  >102 publications with DKK1 and LRP6
 WNT1 antibody  >38 publications with DKK1 and WNT1
 KREMEN1 antibody  >18 publications with DKK1 and KREMEN1
 KREMEN2 antibody  >15 publications with DKK1 and KREMEN2
 RSPO1 antibody  >10 publications with DKK1 and RSPO1
 FZD1 antibody  >10 publications with DKK1 and FZD1
 FZD8 antibody  >4 publications with DKK1 and FZD8
 Products by Pathway  Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Presenilin Action In Notch And Wnt Signaling Pathway antibodies  Presenilin Action In Notch And Wnt Signaling Pathway Diagram
 RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway antibodies  RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway Diagram
 Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies  Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By WNT In Cancer Pathway antibodies  Signaling By WNT In Cancer Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 TCF Dependent Signaling In Response To WNT Pathway antibodies  TCF Dependent Signaling In Response To WNT Pathway Diagram
Diseases associated with anti-DKK1 antibodyOrgans/Tissues associated with anti-DKK1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >87 publications with DKK1 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >40 publications with DKK1 and Nervous System Diseases
 Inflammation Antibodies  >38 publications with DKK1 and Inflammation
 Adenocarcinoma Antibodies  >38 publications with DKK1 and Adenocarcinoma
 Brain Diseases Antibodies  >36 publications with DKK1 and Brain Diseases
 Breast Neoplasms Antibodies  >35 publications with DKK1 and Breast Neoplasms
 Necrosis Antibodies  >34 publications with DKK1 and Necrosis
 Carcinoma, Hepatocellular Antibodies  >32 publications with DKK1 and Carcinoma, Hepatocellular
 Fractures, Bone Antibodies  >32 publications with DKK1 and Fractures, Bone
 Neoplasm Metastasis Antibodies  >31 publications with DKK1 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >471 publications with DKK1 and Bone
 Embryonic Tissue Antibodies  >101 publications with DKK1 and Embryonic Tissue
 Bone Marrow Antibodies  >99 publications with DKK1 and Bone Marrow
 Brain Antibodies  >79 publications with DKK1 and Brain
 Connective Tissue Antibodies  >75 publications with DKK1 and Connective Tissue
 Vascular Antibodies  >56 publications with DKK1 and Vascular
 Liver Antibodies  >49 publications with DKK1 and Liver
 Skin Antibodies  >47 publications with DKK1 and Skin
 Muscle Antibodies  >46 publications with DKK1 and Muscle
 Lung Antibodies  >39 publications with DKK1 and Lung
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