View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List anti-DNAM-1 antibody :: Rabbit anti-Mouse DNAM-1 Monoclonal Antibody Catalog # MBS2544521 Unit / Price 0.06 mL / $345 +1 FREE 8GB USB 0.12 mL / $530 +1 FREE 8GB USB 0.2 mL / $810 +1 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name DNAM-1, Monoclonal Antibody Full Product Name Rabbit anti Mouse DNAM-1 Monoclonal Antibody Product Gene Name anti-DNAM-1 antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP OMIM U56102 mRNA Clonality Monoclonal Isotype IgG Host Rabbit Species Reactivity Mouse Immunogen Recombinant Mouse CD226 protein Buffer This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD226/DNAM-1 (rM CD226; NP_848802.2; Met 1-Pro 254). Preparation and Storage This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -70 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Other Notes Small volumes of anti-DNAM-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-DNAM-1 antibody The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD226, also known as PTA1 or DNAM-1, is a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set. High rate of CD226 (Cluster of Differentiation 226) is found on the surface of natural killer cells, platelets, monocytes and a subset of T cells. CD226 have binding sites with CD112 and CD155 and mediate cellular adhesion to other cells containing its ligands. Applications Tested/Suitable for anti-DNAM-1 antibody ELISA (EIA) Application Notes for anti-DNAM-1 antibody ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Mouse CD226. The detection limit for Mouse CD226 is 0.0049 ng/well. TOP NCBI/Uniprot data below describe general gene information for DNAM-1. It may not necessarily be applicable to this product. NCBI GI # 1401185 NCBI GeneID 10666 UniProt Secondary Accession # B2R818[Other Products] UniProt Related Accession # Q15762[Other Products] Molecular Weight 38,614 Da TOP NCBI Official Full Name DNAM-1 NCBI Official Synonym Full Names CD226 molecule NCBI Official Symbol CD226 [Similar Products] NCBI Official Synonym Symbols PTA1; DNAM1; DNAM-1; TLiSA1 [Similar Products] NCBI Protein Information CD226 antigen UniProt Protein Name CD226 antigen UniProt Synonym Protein Names DNAX accessory molecule 1; DNAM-1; CD_antigen: CD226 UniProt Gene Name CD226 [Similar Products] UniProt Synonym Gene Names DNAM1; DNAM-1 [Similar Products] UniProt Entry Name CD226_HUMAN TOP NCBI Summary for DNAM-1 This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] TOP UniProt Comments for DNAM-1 DNAM-1: Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integralChromosomal Location of Human Ortholog: 18q22.3Cellular Component: cell surface; cell-cell adherens junction; integral to plasma membrane; lipid raft; plasma membraneMolecular Function: cell adhesion molecule binding; integrin binding; protein binding; protein homodimerization activity; protein kinase binding; receptor activityBiological Process: cell adhesion; cell recognition; heterophilic cell adhesion; homophilic cell adhesion; positive regulation of immunoglobulin mediated immune response; positive regulation of mast cell activation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; regulation of immune response; signal transduction Research Articles on DNAM-1 1. CD226 rs763361 polymorphism was significantly associated with susceptibility to T1D. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. 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TOP Products associated with anti-DNAM-1 antibody Reference Product PubMed Publications TIGIT antibody >28 publications with DNAM-1 and TIGIT FYN antibody >6 publications with DNAM-1 and FYN NCR2 antibody >3 publications with DNAM-1 and NCR2 Pathways associated with anti-DNAM-1 antibody Products by Pathway Pathway Diagram Adaptive Immune System Pathway antibodies Adaptive Immune System Pathway Diagram Cell Adhesion Molecules (CAMs) Pathway antibodies Cell Adhesion Molecules (CAMs) Pathway Diagram Cell Adhesion Molecules (CAMs) Pathway antibodies Cell Adhesion Molecules (CAMs) Pathway Diagram Immune System Pathway antibodies Immune System Pathway Diagram Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram Diseases associated with anti-DNAM-1 antibody Disease Name Pubmed Publications Immune System Diseases Antibodies >81 publications with DNAM-1 and Immune System Diseases Inflammation Antibodies >22 publications with DNAM-1 and Inflammation Nervous System Diseases Antibodies >18 publications with DNAM-1 and Nervous System Diseases Cardiovascular Diseases Antibodies >16 publications with DNAM-1 and Cardiovascular Diseases Diabetes Mellitus Antibodies >15 publications with DNAM-1 and Diabetes Mellitus Necrosis Antibodies >14 publications with DNAM-1 and Necrosis Respiratory Tract Diseases Antibodies >13 publications with DNAM-1 and Respiratory Tract Diseases Diabetes Mellitus, Type 1 Antibodies >13 publications with DNAM-1 and Diabetes Mellitus, Type 1 Lupus Erythematosus, Systemic Antibodies >11 publications with DNAM-1 and Lupus Erythematosus, Systemic Lung Neoplasms Antibodies >8 publications with DNAM-1 and Lung Neoplasms Organs/Tissues associated with anti-DNAM-1 antibody Organ/Tissue Name Pubmed Publications Blood Antibodies >193 publications with DNAM-1 and Blood Lung Antibodies >16 publications with DNAM-1 and Lung Vascular Antibodies >12 publications with DNAM-1 and Vascular Lymph Node Antibodies >10 publications with DNAM-1 and Lymph Node Liver Antibodies >9 publications with DNAM-1 and Liver Kidney Antibodies >6 publications with DNAM-1 and Kidney Spleen Antibodies >6 publications with DNAM-1 and Spleen Mixed Antibodies >6 publications with DNAM-1 and Mixed Heart Antibodies >5 publications with DNAM-1 and Heart Thymus Antibodies >4 publications with DNAM-1 and Thymus TOP