Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow DR5 rightarrow Monoclonal DR5  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • 14-3-3 Protein (14-3-3 Pro) ELISA Kit
 • Lysosome-associated membrane glycoprotein 2 (Lamp2) ELISA Kit
 • Antithrombin Receptor (ATR) ELISA Kit
 • Glutathione (GT) ELISA Kit
 • fibroblast growth factor 2 (basic) (FGF2) ELISA Kit
 • Kallikrein-8 (Klk8) Recombinant Protein
 • Fibroblast Growth Factor-4 (FGF-4) Active Protein
 • serpin peptidase inhibitor, clade E (nexin, plasminogen acti... ELISA Kit
 • Monoamine oxidase (Maoa) Assay Kit
 • FNDC3B Antibody
 • CD30 ELISA Kit
 • Biliverdin reductase A (Blvra) Recombinant Protein
 • Plasmin-antiplasmin complex (PAP) ELISA Kit
 • Elk1 Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-DR5 antibody :: anti-Human, Mouse DR5 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS475077
Unit / Price
0.1 mL  /  $335 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DR5, Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti-DR5 Mouse mAb

 Product Synonym Names    Fas like protein; Apoptosis inducing protein TRICK2A/2B; Apoptosis inducing receptor TRAIL R2; CD 262; CD262; CD262 antigen; Cytotoxic TRAIL receptor 2; Death domain containing receptor for TRAIL/Apo 2L; Death domain containing receptor for TRAIL/Apo2L; Death receptor 5; DR 5; DR5; Fas like protein precursor; KILLER; KILLER/DR5; OTTHUMP00000123492; OTTHUMP00000123493; p53 regulated DNA damage inducible cell death receptor (killer); p53 regulated DNA damage inducible cell death receptor (killer); TNF related apoptosis inducing ligand receptor 2; TNF related apoptosis inducing ligand receptor 2; TNF-related apoptosis-inducing ligand receptor 2; TNFRSF10B; TR10B_HUMAN; TRAIL R2; TRAIL receptor 2; TRAIL-R2; TRAILR2; TRANCER; TRICK2; TRICK2A; TRICK2B; TRICKB; Tumor necrosis factor receptor like protein ZTNFR9; Tumor necrosis factor receptor like protein ZTNFR9; Tumor necrosis factor receptor superfamily member 10b; Tumor necrosis factor receptor superfamily, member 10b; ZTNFR9
 Product Gene Name   

anti-DR5 antibody

[Similar Products]
 Product Synonym Gene Name    tnfrsf10b; DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5. [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    AF018657 mRNA
 3D Structure    ModBase 3D Structure for O14763
Section Bar
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    7F4-F8-G11
 Host    Mouse
Source: Human
 Species Reactivity    Human, Mouse
Section Bar
 Purity/Purification    Affinity Purified
 Form/Format    Purified mouse monoclonal in PBS (pH 7.4) containing with 0.02% sodium azide, 0.1mg/mlBSA and 50% glycerol.
 Concentration    0.4mg/ml (lot specific)
Section Bar
 Immunogen    Purified recombinant human DR5 protein fragments expressed in E Coli.
 Sensitivity    This antibody detects endogenous levels of DR5 and does not cross-react with related proteins.
 Sequence Similarities    Contains 1 death domain.Contains 3 TNFR-Cys repeats.
 Subunit Structure    Homotrimer.Can interact with TRADD and RIPK1.
 Subcellular Location    Membrane; Single-pass type I membrane protein.
Section Bar
 Other Notes    Small volumes of anti-DR5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-DR5 antibody

   Entrez Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain.This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal.Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.[provided by RefSeq, Mar 2009]
 Product Categories/Family for anti-DR5 antibody    Cancer; Growth factors; TNF; Signal Transduction; Signaling Pathway; Nuclear Signaling; NFkB Pathway; Signal Transduction; Growth Factors/Hormones; TNF; Cell Biology; Apoptosis
 Applications Tested/Suitable for anti-DR5 antibody   

Western Blot (WB), Immunocytochemistry (ICC)

 Application Notes for anti-DR5 antibody    WB: 1:500-1:2000
ICC: 1:100
Section Bar
 Western Blot (WB) of anti-DR5 antibody    Western blot detection of DR5 in Mouse kindey, Mouse brain, HCT116 and Hela cell lysates using DR5 mouse mAb (1:500-1:2000 diluted).Predicted band size:40/48KDa.Observed band size:40/48KDa.
anti-DR5 antibody Western Blot (WB) (WB) image
Section Bar
 Immunocytochemistry (ICC) of anti-DR5 antibody    Immunocytochemistry of HeLa cells fixed by Paraformaldehyde and using DR5 mouse mAb diluted 1:100.
anti-DR5 antibody Immunocytochemistry (ICC) (ICC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for DR5. It may not necessarily be applicable to this product.
 NCBI GI #    224494019
 NCBI GeneID    8795
 NCBI Accession #    NP_003833.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_003842 [Other Products]
Section Bar
 UniProt Primary Accession #    O14763 [Other Products]
 UniProt Secondary Accession #    O14720; O15508; O15517; O15531; Q6UXM8; Q7Z360; Q9BVE0 [Other Products]
 UniProt Related Accession #    O14763 [Other Products]
 Molecular Weight    48
Table BarTOPTable Bar
 NCBI Official Full Name    tumor necrosis factor receptor superfamily member 10B isoform 1
 NCBI Official Synonym Full Names    TNF receptor superfamily member 10b
 NCBI Official Symbol    TNFRSF10B [Similar Products]
 NCBI Official Synonym Symbols   
DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 10B
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 10B
 UniProt Synonym Protein Names   
Death receptor 5; TNF-related apoptosis-inducing ligand receptor 2; TRAIL receptor 2; TRAIL-R2; CD_antigen: CD262
 UniProt Gene Name    TNFRSF10B [Similar Products]
 UniProt Synonym Gene Names    DR5; KILLER; TRAILR2; TRICK2; ZTNFR9; TRAIL receptor 2; TRAIL-R2 [Similar Products]
Section Bar
 NCBI Summary for DR5    The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
Section Bar
 UniProt Comments for DR5    TRAIL-R2: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Homotrimer. Can interact with TRADD and RIPK1. Regulated by p53/TP53. Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8p21.3

Cellular Component: cell surface; integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; tumor necrosis factor receptor activity

Biological Process: caspase activation; cell surface receptor linked signal transduction; immune response; induction of apoptosis via death domain receptors; inflammatory response; multicellular organismal development; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of apoptosis; regulation of cell proliferation; response to lipopolysaccharide

Disease: Squamous Cell Carcinoma, Head And Neck
Table BarTOPTable Bar
 Research Articles on DR5    1. CAPE/TRAIL stimulated apoptosis through the binding of TRAIL to DR5. Moreover, expression of transcription factor C/EBP homologous protein (CHOP) markedly increased in response to CAPE and transient knockdown of CHOP abolished CAPE/TRAIL-mediated apoptosis.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-DR5 antibodyPathways associated with anti-DR5 antibody
 Reference Product  PubMed Publications
 TNFSF10 antibody  >2722 publications with DR5 and TNFSF10
 CASP8 antibody  >782 publications with DR5 and CASP8
 FADD antibody  >413 publications with DR5 and FADD
 CFLAR antibody  >156 publications with DR5 and CFLAR
 TRADD antibody  >48 publications with DR5 and TRADD
 CASP10 antibody  >36 publications with DR5 and CASP10
 TP53 antibody  >29 publications with DR5 and TP53
 RIPK1 antibody  >21 publications with DR5 and RIPK1
 IKBKB antibody  >16 publications with DR5 and IKBKB
 IKBKG antibody  >1 publications with DR5 and IKBKG
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Caspase-8 Activation By Cleavage Pathway antibodies  Caspase-8 Activation By Cleavage Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 DNA Damage Response Pathway antibodies  DNA Damage Response Pathway Diagram
 Death Receptor Signalling Pathway antibodies  Death Receptor Signalling Pathway Diagram
Diseases associated with anti-DR5 antibodyOrgans/Tissues associated with anti-DR5 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >2041 publications with DR5 and Necrosis
 Neoplasms Antibodies  >1684 publications with DR5 and Neoplasms
 Leukemia Antibodies  >248 publications with DR5 and Leukemia
 Liver Diseases Antibodies  >163 publications with DR5 and Liver Diseases
 Breast Neoplasms Antibodies  >158 publications with DR5 and Breast Neoplasms
 Lung Neoplasms Antibodies  >151 publications with DR5 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >143 publications with DR5 and Neoplasms, Experimental
 Lung Diseases Antibodies  >141 publications with DR5 and Lung Diseases
 Colonic Neoplasms Antibodies  >139 publications with DR5 and Colonic Neoplasms
 Inflammation Antibodies  >133 publications with DR5 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >469 publications with DR5 and Blood
 Liver Antibodies  >218 publications with DR5 and Liver
 Lung Antibodies  >199 publications with DR5 and Lung
 Prostate Antibodies  >162 publications with DR5 and Prostate
 Brain Antibodies  >104 publications with DR5 and Brain
 Vascular Antibodies  >78 publications with DR5 and Vascular
 Kidney Antibodies  >75 publications with DR5 and Kidney
 Skin Antibodies  >65 publications with DR5 and Skin
 Bone Marrow Antibodies  >57 publications with DR5 and Bone Marrow
 Muscle Antibodies  >36 publications with DR5 and Muscle
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions