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anti-DCN antibody :: Mouse anti-Human Decorin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS606237 anti-DCN antibody
Unit / Price
0.5 mg  /  $760 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Decorin (DCN), Monoclonal Antibody

 Also Known As   

Decorin (DCN, Bone Proteoglycan II, CSCD, DSPG2, PG40, PGII, PGS2, Small Leucine Rich Protein 1B, SLRR1B)

 Product Synonym Names    Anti -Decorin (DCN, Bone Proteoglycan II, CSCD, DSPG2, PG40, PGII, PGS2, Small Leucine Rich Protein 1B, SLRR1B)
 Product Gene Name   

anti-DCN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.11 (91539035..91576806, complement). Location: 12q21.33
 OMIM    125255
 3D Structure    ModBase 3D Structure for P07585
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    9j121
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human Decorin in direct ELISAs.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as lyophilized tissue culture supernatant in PBS, pH 7.2, 5% trehalose. Reconstitution: sterile PBS using 1ml of PBSfor a final concentration of 0.5mg/ml.
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 Immunogen    Sf 21-derived rhDecorin
 Hybridoma    Fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, Sf 21-derived, recombinant human Decorin (rhDecorin; aa 17-359; Accession # Q5R1V9).
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 Preparation and Storage    Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 24 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-DCN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DCN antibody

   Decorin is a small secreted leucine rich proteoglycan that binds to fibronectin, TGF- and type I and type II collagen. Decorin has been implicated in the assembly of the extracellular matrix and the inhibition of tumor progression.
 Product Categories/Family for anti-DCN antibody    Antibodies; Abs to Carbohydrates, Glycoproteins
 Applications Tested/Suitable for anti-DCN antibody   

ELISA (EL/EIA)

 Application Notes for anti-DCN antibody    Suitable for use in ELISA.
Dilution: ELISA: Used as a capture reagent in a human Decorin sandwich immunoassay in combination with biotinylated, human Decorin detection antibody and recombinant human Decorin as the
standard. The suggested coating concentration range is 2-8ug/ml and should be titrated to determine the optimal concentration.
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NCBI/Uniprot data below describe general gene information for DCN. It may not necessarily be applicable to this product.
 NCBI GI #    181519
 NCBI GeneID    1634
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 UniProt Primary Accession #    P07585 [Other Products]
 UniProt Secondary Accession #    Q9P0Z0; Q9P0Z1; Q9Y5N8; Q9Y5N9 [Other Products]
 UniProt Related Accession #    P07585; Q6FH10 [Other Products]
 Molecular Weight    39,747 Da [Similar Products]
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 NCBI Official Full Name    decorin
 NCBI Official Synonym Full Names    decorin
 NCBI Official Symbol    DCN [Similar Products]
 NCBI Official Synonym Symbols   
CSCD; PG40; PGII; PGS2; DSPG2; SLRR1B
[Similar Products]
 NCBI Protein Information    decorin; PG-S2; bone proteoglycan II; decorin proteoglycan; proteoglycan core protein; small leucine-rich protein 1B; dermatan sulphate proteoglycans II
 UniProt Protein Name    Decorin
 UniProt Synonym Protein Names   
Bone proteoglycan II; PG-S2; PG40
 Protein Family    Decorin
 UniProt Gene Name    DCN [Similar Products]
 UniProt Synonym Gene Names    SLRR1B [Similar Products]
 UniProt Entry Name    PGS2_HUMAN
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 NCBI Summary for DCN    The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome. [provided by RefSeq]
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 UniProt Comments for DCN    DCN: May affect the rate of fibrils formation. Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD). Corneal dystrophies are inherited, bilateral, primary alterations of the cornea that are not associated with prior inflammation or secondary to systemic disease. Most show autosomal dominant inheritance. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Extracellular matrix; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q21.33

Cellular Component: extracellular matrix; lysosomal lumen; proteinaceous extracellular matrix; extracellular space; Golgi lumen; extracellular region; collagen type VI

Molecular Function: collagen binding; glycosaminoglycan binding; extracellular matrix binding; protein N-terminus binding

Biological Process: extracellular matrix organization and biogenesis; skeletal muscle development; chondroitin sulfate biosynthetic process; wound healing; glycosaminoglycan metabolic process; pathogenesis; response to lipopolysaccharide; dermatan sulfate biosynthetic process; chondroitin sulfate metabolic process; extracellular matrix disassembly; organ morphogenesis; response to mechanical stimulus; chondroitin sulfate catabolic process; carbohydrate metabolic process; kidney development; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; placenta development; aging

Disease: Corneal Dystrophy, Congenital Stromal
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 Research Articles on DCN    1. Oxidative stress-mediated decorin GAG chain synthesis triggers TGF-beta signaling and mineralization of vascular smooth muscle cells in vitro.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DCN antibodyPathways associated with anti-DCN antibody
 Reference Product  PubMed Publications
 TGFB1 antibody  >75 publications with DCN and TGFB1
 Products by Pathway  Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 Validated Transcriptional Targets Of AP1 Family Members Fra1 And Fra2 Pathway antibodies  Validated Transcriptional Targets Of AP1 Family Members Fra1 And Fra2 Pathway Diagram
Diseases associated with anti-DCN antibodyOrgans/Tissues associated with anti-DCN antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >149 publications with DCN and Neoplasms
 Neurologic Manifestations Antibodies  >114 publications with DCN and Neurologic Manifestations
 Fibrosis Antibodies  >104 publications with DCN and Fibrosis
 Carcinoma Antibodies  >57 publications with DCN and Carcinoma
 Female Urogenital Diseases Antibodies  >53 publications with DCN and Female Urogenital Diseases
 Genetic Diseases, Inborn Antibodies  >51 publications with DCN and Genetic Diseases, Inborn
 Male Urogenital Diseases Antibodies  >48 publications with DCN and Male Urogenital Diseases
 Hearing Loss Antibodies  >47 publications with DCN and Hearing Loss
 Death Antibodies  >46 publications with DCN and Death
 Inflammation Antibodies  >46 publications with DCN and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >612 publications with DCN and Brain
 Nerve Antibodies  >269 publications with DCN and Nerve
 Connective Tissue Antibodies  >158 publications with DCN and Connective Tissue
 Skin Antibodies  >157 publications with DCN and Skin
 Muscle Antibodies  >140 publications with DCN and Muscle
 Bone Antibodies  >138 publications with DCN and Bone
 Vascular Antibodies  >119 publications with DCN and Vascular
 Ear Antibodies  >79 publications with DCN and Ear
 Kidney Antibodies  >74 publications with DCN and Kidney
 Embryonic Tissue Antibodies  >60 publications with DCN and Embryonic Tissue
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