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anti-DSC2 antibody :: Mouse anti-Human Desmocollin-2,3 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS602772 anti-DSC2 antibody
Unit / Price
0.1 mg  /  $620 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Desmocollin-2,3 (DSC2), Monoclonal Antibody

 Also Known As   


 Product Synonym Names    Anti -Desmocollin-2,3
 Product Gene Name   

anti-DSC2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 18; NC_000018.9 (28645942..28682388, complement). Location: 18q12.1
 OMIM    125645
 3D Structure    ModBase 3D Structure for Q02487
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    3G130
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes the ~120kD desmocollin-2 and ~105kD desmocollin-3 human protein, with particularly strong reaction to desmocollin-2. Crossreactivity with other desmocollin family members has not been observed.
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
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 Immunogen    Human desmocollin-2 extracellular domain
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-DSC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DSC2 antibody

   Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. The desmosome is subdivided into two regions. The plaque region lies adjacent to the plasma, and is believed to contain molecules that attach the intermediate filament cytoskeleton to the desmosome. The core region is composed of transmembrane glycoproteins that are thought to mediate cell-cell adhesion. Desmogleins and desmocollins are the main desmosomal transmembrane proteins. These desmosomal glycoproteins belong to the members of the cadherin family of adhesion molecules. Three different isoforms of both desmogleins and desmocollins have been identified, named as desmoglein1-3 and desmocollin1-3. Desmosomal cadherins showed differentiation- specific expression in the human epidermis, although the functional significance of this differential expression is not fully understood. Desmocollin-1 can be found in the upper layers. The expression of desmocollin-2 varies in the basal and suprabasal layers. And desmocollin-3 is expressed more evenly throughout the suprabasal layers. Domain specific desmosomal and adherens junction-associated antibodies have been widely used in recent studies. In one study, domain specific antibodies were used to determine the cellular localization of the skin of patients with Hailey-Hailey disease and Darier's disease. Desmosomal cadherin antibodies are also useful for targeting specific disease and in the study of interaction between cell adhesion proteins.
 Product Categories/Family for anti-DSC2 antibody    Antibodies; Abs to Proteins
 Applications Tested/Suitable for anti-DSC2 antibody   

Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF)

 Application Notes for anti-DSC2 antibody    Suitable for use in Immunoprecipitation, Western Blot and Immunofluorescence., Recommended Dilutions:, Immunoprecipitation (Native): 5-10ug, Western Blot (ECL): 1-3ug/ml, Immuno uorescence: 20-50ug/ml, Optimal dilutions to be determined by the researcher., Recommended Positive Control:, A0001-50: A431 Cells, Non-Stimulated
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NCBI/Uniprot data below describe general gene information for DSC2. It may not necessarily be applicable to this product.
 NCBI GI #    13435366
 NCBI GeneID    1824
 NCBI Accession #    NP_004940.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004949.3 [Other Products]
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 UniProt Primary Accession #    Q02487 [Other Products]
 UniProt Related Accession #    Q02487; Q63HM4; Q68DY8 [Other Products]
 Molecular Weight    99,962 Da [Similar Products]
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 NCBI Official Full Name    desmocollin-2 isoform Dsc2b preproprotein
 NCBI Official Synonym Full Names    desmocollin 2
 NCBI Official Symbol    DSC2 [Similar Products]
 NCBI Official Synonym Symbols   
DG2; DSC3; CDHF2; ARVD11; DGII/III; DKFZp686I11137
[Similar Products]
 NCBI Protein Information    desmocollin-2; OTTHUMP00000162822; OTTHUMP00000162823; cadherin family member 2; desmosomal glycoprotein II; desmosomal glycoprotein III; desmosomal glycoprotein II/III
 UniProt Protein Name    Desmocollin-2
 UniProt Synonym Protein Names   
Cadherin family member 2; Desmocollin-3; Desmosomal glycoprotein II; Desmosomal glycoprotein III
 Protein Family    Desmocollin
 UniProt Gene Name    DSC2 [Similar Products]
 UniProt Synonym Gene Names    CDHF2; DSC3 [Similar Products]
 UniProt Entry Name    DSC2_HUMAN
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 NCBI Summary for DSC2    The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq]
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 UniProt Comments for DSC2    DSC2: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Defects in DSC2 are the cause of familial arrhythmogenic right ventricular dysplasia type 11 (ARVD11); also known as arrhythmogenic right ventricular cardiomyopathy 11 (ARVC11). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 18q12.1

Cellular Component: desmosome; cell-cell adherens junction; plasma membrane; integral to membrane; cytoplasmic vesicle

Molecular Function: protein binding; calcium ion binding

Biological Process: homophilic cell adhesion; cell adhesion; cellular response to starvation

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 11
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 Research Articles on DSC2    1. Report mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DSC2 antibodyPathways associated with anti-DSC2 antibody
 Reference Product  PubMed Publications
 DSG2 antibody  >37 publications with DSC2 and DSG2
 PKP2 antibody  >21 publications with DSC2 and PKP2
 JUP antibody  >14 publications with DSC2 and JUP
 DSG1 antibody  >10 publications with DSC2 and DSG1
 PKP3 antibody  >1 publications with DSC2 and PKP3
 Products by Pathway  Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Diseases associated with anti-DSC2 antibodyOrgans/Tissues associated with anti-DSC2 antibody
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >23 publications with DSC2 and Heart Diseases
 Cardiomyopathies Antibodies  >23 publications with DSC2 and Cardiomyopathies
 Congenital Abnormalities Antibodies  >22 publications with DSC2 and Congenital Abnormalities
 Heart Defects, Congenital Antibodies  >21 publications with DSC2 and Heart Defects, Congenital
 Neoplasms Antibodies  >13 publications with DSC2 and Neoplasms
 Skin Diseases Antibodies  >10 publications with DSC2 and Skin Diseases
 Carcinoma Antibodies  >7 publications with DSC2 and Carcinoma
 Death, Sudden, Cardiac Antibodies  >7 publications with DSC2 and Death, Sudden, Cardiac
 Heart Failure Antibodies  >6 publications with DSC2 and Heart Failure
 Carcinoma, Squamous Cell Antibodies  >4 publications with DSC2 and Carcinoma, Squamous Cell
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >13 publications with DSC2 and Muscle
 Mouth Antibodies  >6 publications with DSC2 and Mouth
 Kidney Antibodies  >4 publications with DSC2 and Kidney
 Lymph Node Antibodies  >4 publications with DSC2 and Lymph Node
 Blood Antibodies  >4 publications with DSC2 and Blood
 Esophagus Antibodies  >4 publications with DSC2 and Esophagus
 Embryonic Tissue Antibodies  >3 publications with DSC2 and Embryonic Tissue
 Lung Antibodies  >2 publications with DSC2 and Lung
 Brain Antibodies  >2 publications with DSC2 and Brain
 Intestine Antibodies  >2 publications with DSC2 and Intestine
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