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anti-DSG1 antibody :: Mouse Desmoglein-1 (DSG1) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS439914
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Desmoglein-1 (DSG1), Monoclonal Antibody

★Popular Item★
 Also Known As   

Desmoglein-1 (DSG1)

 Product Synonym Names    Cadherin family member 4; CDHF4; Desmoglein-1; Desmosomal glycoprotein 1; DG1; DSG1; EPKHE; EPKHIA; Pemphigus foliaceus antigen; PPKS1; SPPK1
 Product Gene Name   

anti-DSG1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q02413
 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    DSG1/1733
 Host    Mouse
 Species Reactivity    Human. Others not known.
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 Specificity    Recognizes a protein of ~150kDa, identified as Desmoglein-1 (DSG1). Desmoglein-1 is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Immunogen    Recombinant human desmoglein-1 protein fragment corresponding to intracellular domain
 Cellular Localization    Cell Surface
 Hu-chromosome Location    18q12.1
 Positive Control    A431 or A-375 cells. Skin
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of anti-DSG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-DSG1 antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

 Application Notes for anti-DSG1 antibody    FC/FACS: 0.5-1ug/million cells
IF: 1-2ug/ml
IHC-F: 0.5-1ug/ml for 30 minutes at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris buffer with 1mM EDTA, pH 8.0, for 10-20 min followed by cooling at RT for 20 minutes.
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 Immunohistochemistry (IHC) of anti-DSG1 antibody    Formalin-fixed, paraffin-embedded human Skin stained with Desmoglein-1 Monoclonal Antibody (DSG1/1733).
anti-DSG1 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-DSG1 antibody    Western Blot Analysis of Daudi Cell Lysate using MALT1 Monoclonal Antibody (MT1/410)
anti-DSG1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for DSG1. It may not necessarily be applicable to this product.
 NCBI GI #    119703744
 NCBI GeneID    1828
 NCBI Accession #    NP_001933.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001942.3 [Other Products]
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 UniProt Primary Accession #    Q02413 [Other Products]
 UniProt Secondary Accession #    B7Z845 [Other Products]
 UniProt Related Accession #    Q02413 [Other Products]
 Molecular Weight    150kDa (precursor); 160kDa (mature)
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 NCBI Official Full Name    desmoglein-1 preproprotein
 NCBI Official Synonym Full Names    desmoglein 1
 NCBI Official Symbol    DSG1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    desmoglein-1
 UniProt Protein Name    Desmoglein-1
 UniProt Synonym Protein Names   
Cadherin family member 4; Desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen
 Protein Family    Desmoglein
 UniProt Gene Name    DSG1 [Similar Products]
 UniProt Synonym Gene Names    CDHF4; DG1; DGI [Similar Products]
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 NCBI Summary for DSG1    This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]
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 UniProt Comments for DSG1    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
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Product References and Citations for anti-DSG1 antibody

   Wu, H., Stanley, J.R. and Cotsarelis, G. Desmoglein isotype expression in the hair follicle and its cysts correlates with type of keratinization and degree of differentiation. J Invest Dermatol 2003, 120: 1052-1057.
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 Research Articles on DSG1    1. Here the authors identify a potential mechanism by which desmosomes assist the de-neddylating COP9 signalosome (CSN) in attenuating EGFR through an association between the Cops3 subunit of the CSN and desmosomal components, Desmoglein1 (Dsg1) and Desmoplakin (Dp), to promote epidermal differentiation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DSG1 antibodyPathways associated with anti-DSG1 antibody
 Reference Product  PubMed Publications
 DSC2 antibody  >11 publications with DSG1 and DSC2
 PKP1 antibody  >6 publications with DSG1 and PKP1
 KLK5 antibody  >6 publications with DSG1 and KLK5
 JUP antibody  >5 publications with DSG1 and JUP
 PKP2 antibody  >2 publications with DSG1 and PKP2
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cell Adhesion Proteins Pathway antibodies  Apoptotic Cleavage Of Cell Adhesion Proteins Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
Diseases associated with anti-DSG1 antibodyOrgans/Tissues associated with anti-DSG1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >38 publications with DSG1 and Neoplasms
 Hypotrichosis Antibodies  >7 publications with DSG1 and Hypotrichosis
 Drug Toxicity Antibodies  >4 publications with DSG1 and Drug Toxicity
 Heart Diseases Antibodies  >3 publications with DSG1 and Heart Diseases
 Weight Loss Antibodies  >3 publications with DSG1 and Weight Loss
 Lung Diseases Antibodies  >3 publications with DSG1 and Lung Diseases
 Cardiovascular Diseases Antibodies  >2 publications with DSG1 and Cardiovascular Diseases
 Inflammation Antibodies  >2 publications with DSG1 and Inflammation
 Keratosis palmoplantaris striata 1 Antibodies  >2 publications with DSG1 and Keratosis palmoplantaris striata 1
 Neoplasm Metastasis Antibodies  >1 publications with DSG1 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >232 publications with DSG1 and Skin
 Mouth Antibodies  >21 publications with DSG1 and Mouth
 Connective Tissue Antibodies  >4 publications with DSG1 and Connective Tissue
 Heart Antibodies  >4 publications with DSG1 and Heart
 Stomach Antibodies  >2 publications with DSG1 and Stomach
 Muscle Antibodies  >2 publications with DSG1 and Muscle
 Testis Antibodies  >2 publications with DSG1 and Testis
 Brain Antibodies  >1 publications with DSG1 and Brain
 Intestine Antibodies  >1 publications with DSG1 and Intestine
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