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anti-DBI antibody :: Mouse anti-Human Diazepam Binding Inhibitor Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS609259 anti-DBI antibody
Unit / Price
0.1 mg  /  $545 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Diazepam Binding Inhibitor (DBI), Monoclonal Antibody

 Also Known As   

Diazepam Binding Inhibitor (DBI, Acyl-CoA-binding Protein, ACBP, Endozepine, EP)

 Product Synonym Names    Anti -Diazepam Binding Inhibitor (DBI, Acyl-CoA-binding Protein, ACBP, Endozepine, EP)
 Product Gene Name   

anti-DBI antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (120124504..120130122). Location: 2q12-q21
 OMIM    125950
 3D Structure    ModBase 3D Structure for P07108
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 Clonality    Monoclonal
 Isotype    IgG1, k
 Clone Number    10K185
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human Diazepam Binding Inhibitor.
 Purity/Purification    Ascites
Ascites
 Form/Format    Supplied as a liquid in PBS, 50% glycerol.
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 Immunogen    Recombinant human GST fusion protein purified from E.coli.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-DBI antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DBI antibody

   Diazepam Binding Inhibitor (DBI) is a highly conserved 10kD polypeptide which is expressed in various species range from yeast to mammals. As an inverse agonist for benzodiazepine receptors, DBI downregulates inhibitory effects of GABA. It also has potential to induce anxiety. Found in central andperipheral tissues, DBI also participates in metabolism of steroids, which has been known to partially modify GABAA receptor function in the CNS. In peripheral tissues, DBI plays regulatory roles in steroidogenesis. DBI levels have been reported to be decreased in the cerebrospinal fluid obtained from patients with Alzheimer disease.
 Product Categories/Family for anti-DBI antibody    Antibodies; Abs to Neuroscience
 Applications Tested/Suitable for anti-DBI antibody   

ELISA (EL/EIA), Immunoprecipitation (IP)

 Application Notes for anti-DBI antibody    Suitable for use in ELISA and Immunoprecipitation.
Dilution: Immunoprecipitation: 1-2ul/400ul lysates
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NCBI/Uniprot data below describe general gene information for DBI. It may not necessarily be applicable to this product.
 NCBI GI #    181478
 NCBI GeneID    1622
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 UniProt Primary Accession #    P07108 [Other Products]
 UniProt Secondary Accession #    P08869; Q4VWZ6; Q53SQ7; Q6IB48; Q9UCI8 [Other Products]
 UniProt Related Accession #    P07108 [Other Products]
 Molecular Weight    10,044 Da [Similar Products]
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 NCBI Official Full Name    diazepam binding inhibitor
 NCBI Official Synonym Full Names    diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
 NCBI Official Symbol    DBI [Similar Products]
 NCBI Official Synonym Symbols   
EP; ACBP; ACBD1; CCK-RP; MGC70414
[Similar Products]
 NCBI Protein Information    acyl-CoA-binding protein; endozepine; OTTHUMP00000203626; OTTHUMP00000203627; OTTHUMP00000203628; OTTHUMP00000203629; GABA receptor modulator; diazepam-binding inhibitor; acyl coenzyme A binding protein; acyl-Coenzyme A binding domain containing 1; cholecystokinin-releasing peptide, trypsin-sensitive; diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)
 UniProt Protein Name    Acyl-CoA-binding protein
 UniProt Synonym Protein Names   
Diazepam-binding inhibitor; DBI; Endozepine
 Protein Family    Acyl-CoA-binding protein
 UniProt Gene Name    DBI [Similar Products]
 UniProt Entry Name    ACBP_HUMAN
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 NCBI Summary for DBI    This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]
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 UniProt Comments for DBI    DBI: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. Belongs to the ACBP family. 6 isoforms of the human protein are produced by alternative promoter.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 2q12-q21

Cellular Component: Golgi apparatus; mitochondrion; endoplasmic reticulum

Molecular Function: protein dimerization activity; benzodiazepine receptor binding; lipid binding

Biological Process: behavioral fear response; protein palmitoylation; triacylglycerol metabolic process; learning and/or memory; hair follicle development; transport; lateral ventricle development
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 Research Articles on DBI    1. Gene annotation enrichment analysis revealed ACBP-mediated down-regulation of 18 genes encoding key enzymes in glycerolipid, cholesterol and fatty acid metabolism.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DBI antibodyPathways associated with anti-DBI antibody
 Reference Product  PubMed Publications
 TSPO antibody  >4 publications with DBI and TSPO
 Products by Pathway  Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
Diseases associated with anti-DBI antibodyOrgans/Tissues associated with anti-DBI antibody
 Disease Name  Pubmed Publications
 Diabetes Mellitus Antibodies  >30 publications with DBI and Diabetes Mellitus
 Brain Injuries Antibodies  >29 publications with DBI and Brain Injuries
 Neoplasms Antibodies  >25 publications with DBI and Neoplasms
 Anxiety Disorders Antibodies  >15 publications with DBI and Anxiety Disorders
 Hemorrhage Antibodies  >14 publications with DBI and Hemorrhage
 Liver Diseases Antibodies  >13 publications with DBI and Liver Diseases
 Drug Toxicity Antibodies  >10 publications with DBI and Drug Toxicity
 Neurologic Manifestations Antibodies  >9 publications with DBI and Neurologic Manifestations
 Neoplasms, Experimental Antibodies  >8 publications with DBI and Neoplasms, Experimental
 Carcinoma Antibodies  >7 publications with DBI and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >176 publications with DBI and Brain
 Blood Antibodies  >83 publications with DBI and Blood
 Liver Antibodies  >33 publications with DBI and Liver
 Nerve Antibodies  >29 publications with DBI and Nerve
 Vascular Antibodies  >25 publications with DBI and Vascular
 Adrenal Gland Antibodies  >23 publications with DBI and Adrenal Gland
 Testis Antibodies  >18 publications with DBI and Testis
 Kidney Antibodies  >17 publications with DBI and Kidney
 Heart Antibodies  >14 publications with DBI and Heart
 Pancreas Antibodies  >14 publications with DBI and Pancreas
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