P07108
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
diazepam binding inhibitor
NCBI Official Synonym Full Names
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
NCBI Official Synonym Symbols
EP; ACBP; ACBD1; CCK-RP; MGC70414 [Similar Products]
NCBI Protein Information
acyl-CoA-binding protein; endozepine; OTTHUMP00000203626; OTTHUMP00000203627; OTTHUMP00000203628; OTTHUMP00000203629; GABA receptor modulator; diazepam-binding inhibitor; acyl coenzyme A binding protein; acyl-Coenzyme A binding domain containing 1; cholecystokinin-releasing peptide, trypsin-sensitive; diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)
UniProt Protein Name
Acyl-CoA-binding protein
UniProt Synonym Protein Names
Diazepam-binding inhibitor; DBI; Endozepine
UniProt Entry Name
ACBP_HUMAN
NCBI Summary for DBI
This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]
UniProt Comments for DBI
DBI: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. Belongs to the ACBP family. 6 isoforms of the human protein are produced by alternative promoter.
Protein type: Lipid-binding
Chromosomal Location of Human Ortholog: 2q12-q21
Cellular Component: Golgi apparatus; mitochondrion; endoplasmic reticulum
Molecular Function: protein dimerization activity; benzodiazepine receptor binding; lipid binding
Biological Process: behavioral fear response; triacylglycerol metabolic process; learning and/or memory; protein palmitoylation; hair follicle development; transport; lateral ventricle development
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Products associated with anti-DBI antibody
Pathways associated with anti-DBI antibody
Diseases associated with anti-DBI antibody
Organs/Tissues associated with anti-DBI antibody
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