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anti-DRD1 antibody :: Mouse anti-Mouse, Rat Dopamine Receptor, D1a Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS609461 anti-DRD1 antibody
Unit / Price
0.1 mg  /  $655 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Dopamine Receptor, D1a (DRD1), Monoclonal Antibody

 Also Known As   

Dopamine Receptor, D1a

 Product Synonym Names    Anti -Dopamine Receptor, D1a
 Product Gene Name   

anti-DRD1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 5; NC_000005.9 (174867675..174871163, complement). Location: 5q35.1
 OMIM    126449
 3D Structure    ModBase 3D Structure for P21728
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    2Q48
 Host    Mouse
 Species Reactivity    Mouse, Rat
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 Specificity    Recognizes rat Dopamine Receptor D1a. Species Crossreactivity: Mouse. Does not crossreact with human.
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.6, 0.1% sodium azide.
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 Immunogen    Recombinant rat D1a Receptor, carboxy terminus.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-DRD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DRD1 antibody

   Dopamine is an endogenous catecholamine that influences many cellular activities, including behavior, hormone synthesis and release, blood pressure and intracellular ion transport. A family of at least 5 Dopamine Receptors (DR) genes, D1-D5, have been identified based upon the amino acid identity, pharmacological specificity and effector responses. DR have been classified into either the D1-like (D1, D1B, and D5) or D2-like (D2, D3, and D4). The two isoforms of D2R, D2 long (D2L) and short (D2S), are encoded by splice variants of a single gene and differ only by the presence of an additional 29aa in the intracellular domain 3 of the D2 long form. It may play a role in the coupling of the receptor to G-proteins. All members of this family have similar structure and contain 7 putative transmembrane domains. A given cell or tissue may express more than one DR. Specific radioligands do not exist that can differentiate between these DR. Therefore, specific antibodies are needed to distinguish, localize, and document changes in DR levels in cells and tissues under various normal and pathological conditions.
 Product Categories/Family for anti-DRD1 antibody    Antibodies; Abs to Receptors
 Applications Tested/Suitable for anti-DRD1 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-DRD1 antibody    Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot: 1:250-1:500. Unboiled mouse brain lysate using ECL.
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NCBI/Uniprot data below describe general gene information for DRD1. It may not necessarily be applicable to this product.
 NCBI GI #    4503383
 NCBI GeneID    1812
 NCBI Accession #    NP_000785.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000794.3 [Other Products]
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 UniProt Primary Accession #    P21728 [Other Products]
 UniProt Secondary Accession #    Q4QRJ0; B2RA44 [Other Products]
 UniProt Related Accession #    P21728 [Other Products]
 Molecular Weight    49,293 Da [Similar Products]
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 NCBI Official Full Name    D(1A) dopamine receptor
 NCBI Official Synonym Full Names    dopamine receptor D1
 NCBI Official Symbol    DRD1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    D(1A) dopamine receptor; D(1A) dopamine receptor; dopamine D1 receptor
 UniProt Protein Name    D(1A) dopamine receptor
 UniProt Synonym Protein Names   
Dopamine D1 receptor
 Protein Family    D(1A) dopamine receptor
 UniProt Gene Name    DRD1 [Similar Products]
 UniProt Entry Name    DRD1_HUMAN
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 NCBI Summary for DRD1    This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DRD1    DRD1: a G-protein coupled receptor.One of the five types (D1 to D5) of receptors for dopamine. The most abundant dopamine receptor in the central nervous system. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Interacts with calcyon.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane; plasma membrane; nucleus

Molecular Function: protein binding; dopamine receptor activity; dopamine binding; dopamine D1 receptor-like receptor activity

Biological Process: synaptic transmission, dopaminergic; peristalsis; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); behavioral fear response; prepulse inhibition; positive regulation of potassium ion transport; generation of action potential; thermoregulation; positive regulation of synaptic transmission, glutamatergic; adult walking behavior; G-protein signaling, adenylate cyclase activating pathway; dopamine metabolic process; vasodilation; synaptogenesis; behavioral response to cocaine; protein import into nucleus; conditioned taste aversion; positive regulation of cAMP biosynthetic process; visual learning; dopamine receptor, adenylate cyclase activating pathway; response to drug; grooming behavior; dopamine transport; dentate gyrus development; cerebral cortex GABAergic interneuron migration; striatum development; maternal behavior; response to amphetamine; regulation of dopamine metabolic process; adenylate cyclase activation; regulation of dopamine uptake; mating behavior; transmission of nerve impulse; astrocyte development; memory; G-protein signaling, coupled to cyclic nucleotide second messenger; habituation; glucose import; operant conditioning; sensitization; positive regulation of release of sequestered calcium ion into cytosol; dopamine receptor, phospholipase C activating pathway; positive regulation of cell migration
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 Research Articles on DRD1    1. study investigated the relationship of dopamine D(1) receptor expression between striatal subdivisions and extrastriatal regions in using positron emission tomography
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DRD1 antibodyPathways associated with anti-DRD1 antibody
 Reference Product  PubMed Publications
 ADORA2A antibody  >2 publications with DRD1 and ADORA2A
 GNAS antibody  >1 publications with DRD1 and GNAS
 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
Diseases associated with anti-DRD1 antibodyOrgans/Tissues associated with anti-DRD1 antibody
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >93 publications with DRD1 and Mental Disorders
 Schizophrenia Antibodies  >42 publications with DRD1 and Schizophrenia
 Nervous System Diseases Antibodies  >31 publications with DRD1 and Nervous System Diseases
 Substance-Related Disorders Antibodies  >27 publications with DRD1 and Substance-Related Disorders
 Brain Diseases Antibodies  >26 publications with DRD1 and Brain Diseases
 Central Nervous System Diseases Antibodies  >25 publications with DRD1 and Central Nervous System Diseases
 Bipolar Disorder Antibodies  >19 publications with DRD1 and Bipolar Disorder
 Movement Disorders Antibodies  >12 publications with DRD1 and Movement Disorders
 Hypertension Antibodies  >10 publications with DRD1 and Hypertension
 Depressive Disorder Antibodies  >8 publications with DRD1 and Depressive Disorder
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >71 publications with DRD1 and Brain
 Eye Antibodies  >2 publications with DRD1 and Eye
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