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anti-DRD5 antibody :: Mouse anti-Rat Dopamine Receptor, D1b Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS603453 anti-DRD5 antibody
Unit / Price
0.1 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Dopamine Receptor, D1b (DRD5), Monoclonal Antibody

 Also Known As   

Dopamine Receptor, D1b (D5)

 Product Synonym Names    Anti -Dopamine Receptor, D1b (D5)
 Product Gene Name   

anti-DRD5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_000004.11 (9783258..9785633). Location: 4p16.1
 OMIM    126453
 3D Structure    ModBase 3D Structure for P21918
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 Clonality    Monoclonal
 Isotype    IgG1,k
 Clone Number    8J1312
 Host    Mouse
 Species Reactivity    Rat
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 Specificity    This antibody reacts with Dopamine Receptor D1B. Species Crossreactivity: This antibody reacts with rat protein. Reactivity with mouse protein has had mixed results. It does not react with human protein. Other species have not been tested.
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in Tris-glycine, 150mM sodium chloride, pH 7.2.
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 Immunogen    Recombinant rat D1 (D1b) dopamine receptor (within the last 118 of the C-terminus). [Swiss-Prot# P25115]. Epitope: This antibody has not been epitope mapped.
 Cellular Localization    Cell membrane; Multi-pass membrane protein.
 Positive Control    Sf9 cell lysates.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-DRD5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-DRD5 antibody

   The members of the G protein-coupled receptor family are distinguished by their slow transmitting response to ligand binding. These seven transmembrane proteins include the adrenergic, serotonin, and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. Beta-adrenergic receptor bound to adrenaline activates adenylyl cyclase, while alpha 2-adrenergic receptor bound to adrenaline inhibits adenylyl cyclase. The dopamine receptors are divided into two classes; D1 and D2, which differ in their functional characteristics. D1 receptors stimulate adenylyl cyclase, while D2 receptors inhibit adenylyl cyclase activity. Five different subtypes of dopamine receptor have been described to date. D1DR and D5DR belong to the D1 subclass, while D2DR, D3DR and D4DR belong to the D2 subclass of dopamine receptors.
 Product Categories/Family for anti-DRD5 antibody    Antibodies; Abs to Receptors
 Applications Tested/Suitable for anti-DRD5 antibody   

Western Blot (WB)

 Application Notes for anti-DRD5 antibody    Suitable for use in Western Blot.
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NCBI/Uniprot data below describe general gene information for DRD5. It may not necessarily be applicable to this product.
 NCBI GI #    4503391
 NCBI GeneID    1816
 NCBI Accession #    NP_000789.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000798.4 [Other Products]
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 UniProt Primary Accession #    P21918 [Other Products]
 UniProt Secondary Accession #    Q8NEQ8; B2R9S3 [Other Products]
 UniProt Related Accession #    P21918 [Other Products]
 Molecular Weight    52,951 Da [Similar Products]
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 NCBI Official Full Name    D(1B) dopamine receptor
 NCBI Official Synonym Full Names    dopamine receptor D5
 NCBI Official Symbol    DRD5 [Similar Products]
 NCBI Official Synonym Symbols   
DBDR; DRD1B; DRD1L2; MGC10601
[Similar Products]
 NCBI Protein Information    D(1B) dopamine receptor; D(1B) dopamine receptor; OTTHUMP00000158603; dopamine D5 receptor; dopamine receptor D1B; d(5) dopamine receptor; D1beta dopamine receptor
 UniProt Protein Name    D(1B) dopamine receptor
 UniProt Synonym Protein Names   
D(5) dopamine receptor; D1beta dopamine receptor; Dopamine D5 receptor
 Protein Family    D(1B) dopamine receptor
 UniProt Gene Name    DRD5 [Similar Products]
 UniProt Synonym Gene Names    DRD1B; DRD1L2 [Similar Products]
 UniProt Entry Name    DRD5_HUMAN
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 NCBI Summary for DRD5    This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq]
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 UniProt Comments for DRD5    DRD5: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Defects in DRD5 are a cause of benign essential blepharospasm (BEB). BEB is a primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4p16.1

Cellular Component: brush border membrane; integral to plasma membrane; plasma membrane

Molecular Function: dopamine receptor activity; dopamine binding; dopamine D1 receptor-like receptor activity

Biological Process: synaptic transmission, dopaminergic; wound healing; adenylate cyclase activation; response to amphetamine; transmission of nerve impulse; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; response to cocaine; G-protein signaling, adenylate cyclase activating pathway; cellular calcium ion homeostasis; synaptic transmission; regulation of female receptivity; regulation of systemic arterial blood pressure by vasopressin; sensitization; dopamine receptor, phospholipase C activating pathway; negative regulation of blood pressure; positive regulation of adenylate cyclase activity; negative regulation of NAD(P)H oxidase activity; associative learning; dopamine receptor, adenylate cyclase activating pathway

Disease: Attention Deficit-hyperactivity Disorder; Blepharospasm, Benign Essential
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 Research Articles on DRD5    1. Data show that the D5 receptor shows a trafficking profile distinct from that of any of the other dopamine receptors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DRD5 antibodyPathways associated with anti-DRD5 antibody
 Reference Product  PubMed Publications
 GNAZ antibody  >1 publications with DRD5 and GNAZ
 GABRG2 antibody  >1 publications with DRD5 and GABRG2
 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Dopamine Receptors Pathway antibodies  Dopamine Receptors Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Monoamine GPCRs Pathway antibodies  Monoamine GPCRs Pathway Diagram
Diseases associated with anti-DRD5 antibodyOrgans/Tissues associated with anti-DRD5 antibody
 Disease Name  Pubmed Publications
 Attention Deficit Disorder with Hyperactivity Antibodies  >56 publications with DRD5 and Attention Deficit Disorder with Hyperactivity
 Neurodegenerative Diseases Antibodies  >16 publications with DRD5 and Neurodegenerative Diseases
 Cognition Disorders Antibodies  >10 publications with DRD5 and Cognition Disorders
 Bipolar Disorder Antibodies  >10 publications with DRD5 and Bipolar Disorder
 Hypertension Antibodies  >8 publications with DRD5 and Hypertension
 Psychotic Disorders Antibodies  >4 publications with DRD5 and Psychotic Disorders
 Cardiovascular Diseases Antibodies  >4 publications with DRD5 and Cardiovascular Diseases
 Blepharospasm Antibodies  >3 publications with DRD5 and Blepharospasm
 Seizures Antibodies  >3 publications with DRD5 and Seizures
 Benign essential blepharospasm Antibodies  >3 publications with DRD5 and Benign essential blepharospasm
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >88 publications with DRD5 and Brain
 Eye Antibodies  >3 publications with DRD5 and Eye
 Ovary Antibodies  >1 publications with DRD5 and Ovary
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