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anti-SELE antibody :: Rat anti-Mouse E-selectin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS570065 anti-SELE antibody
Unit / Price
0.1 mg  /  $400 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

E-selectin, Monoclonal Antibody

 Also Known As   

Rat anti E-selectin

 Product Gene Name   

anti-SELE antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (169691781..169703220, complement). Location: 1q22-q25
 OMIM    131210
 3D Structure    ModBase 3D Structure for P16581
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    UZ5
 Host    Rat
 Species Reactivity    Mouse
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 Specificity    UZ5 recognizes a conformational epitope in the CR1 region in murine E-selectin. UZ5 partially inhibits leukocyte adhesion to murine activated endothelial cells.
 Form/Format    Each vial contains 100 ul 1 mg/ml purified antibody in PBS containing 0.09% sodium azide.
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 Source Note    UZ5 is a Rat monoclonal IgG2b antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a Lewis Rat immunized with LPS-activated mlEND1 cells expressing E-selectin at their cell surface.
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 Preparation and Storage    Store at 4 degree C, or in small aliquots at -20 degree C.
 Other Notes    Small volumes of anti-SELE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SELE antibody

   Leukocytes adhere to the blood vessel endothelium during extravasation in postcapillary venules of lymph nodes. In addition, leukocyte adhesion occurs in the capillaries and small venules at any site in the body after onset of inflammation. This response is immediate and involves a cascade of adhesion receptors. At the endothelial surface members of the selectin and immunoglobulin superfamilies participate in this cascade. Selectins are C-type cell surface lectins that play a role in leukocyte adhesion to the blood vessel wall endothelium. E-selectin (CD62E) is an endothelial cell specific selectin that is expressed only after activation with proinflammatory cytokines. In vitro experiments have shown that IL-1, TNFalpha and bacterial wall components like lipopolysaccharides induce the transcription of E-selectin in a NFkappaB dependent signalling cascade. E-selectin has been associated with blood vessel endothelium in diverse inflammatory situations.
 Product Categories/Family for anti-SELE antibody    Cell adhesion, Cell adhesion, Immunology
 Applications Tested/Suitable for anti-SELE antibody   

Flow Cytometry (FC), Immunocytochemistry (IHC), Immunofluorescence (IF), Immunohistochemistry (IHC) (frozen), Immunoprecipitation (IP), Western Blot (WB)

 Application Notes for anti-SELE antibody    UZ5 is suitable for immunoblotting, ELISA, immunoprecipitation, immunohistochemistry on fozen sections and flow cytometry (dilution 1:200).
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NCBI/Uniprot data below describe general gene information for SELE. It may not necessarily be applicable to this product.
 NCBI GI #    187960042
 NCBI GeneID    6401
 NCBI Accession #    NP_000441.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000450.2 [Other Products]
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 UniProt Primary Accession #    P16581 [Other Products]
 UniProt Secondary Accession #    P16111; A2RRD6 [Other Products]
 UniProt Related Accession #    P16581; Q5TI75; Q6ULR7 [Other Products]
 Molecular Weight    66,655 Da [Similar Products]
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 NCBI Official Full Name    E-selectin
 NCBI Official Synonym Full Names    selectin E
 NCBI Official Symbol    SELE [Similar Products]
 NCBI Official Synonym Symbols   
ELAM; ESEL; CD62E; ELAM1; LECAM2
[Similar Products]
 NCBI Protein Information    E-selectin; ELAM-1; OTTHUMP00000032745; OTTHUMP00000032746; OTTHUMP00000032747; OTTHUMP00000032748; OTTHUMP00000032749; endothelial adhesion molecule 1; CD62 antigen-like family member E; endothelial leukocyte adhesion molecule 1; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2
 UniProt Protein Name    E-selectin
 UniProt Synonym Protein Names   
CD62 antigen-like family member E; Endothelial leukocyte adhesion molecule 1; ELAM-1; Leukocyte-endothelial cell adhesion molecule 2
 Protein Family    E-selectin
 UniProt Gene Name    SELE [Similar Products]
 UniProt Synonym Gene Names    ELAM1 [Similar Products]
 UniProt Entry Name    LYAM2_HUMAN
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 NCBI Summary for SELE    The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq]
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 UniProt Comments for SELE    SELE: Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis. Belongs to the selectin/LECAM family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q22-q25

Cellular Component: cortical cytoskeleton; extracellular space; perinuclear region of cytoplasm; integral to membrane; plasma membrane; coated pit; caveola; lipid raft

Molecular Function: protein binding; phospholipase binding; transmembrane receptor activity; sialic acid binding

Biological Process: heterophilic cell adhesion; leukocyte adhesion; phospholipase C activation; positive regulation of leukocyte migration; regulation of inflammatory response; actin filament-based process; positive regulation of receptor internalization; calcium-mediated signaling; response to lipopolysaccharide; inflammatory response; leukocyte tethering or rolling; blood coagulation; leukocyte migration; leukocyte migration during inflammatory response

Disease: Hypertension, Essential
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Product References and Citations for anti-SELE antibody

   Hallmann, R., Zimmermann, U., Sorokin, L. M., Needham, L., and Von der Mark, K. (1995). Adhesion of leukocytes to the inflammed endothelium, Scand J Rheumatol Suppl 101, 107-9. Hammel, M., Weitz-Schmidt, G., Krause, A., Moll, T., Vestweber, D., Zerwes, H. G., and Hallmann, R. (2001). Species-specific and conserved epitopes on Mouse and Human E-selectin important for leukocyte adhesion, Exp Cell Res 269, 266-74.
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 Research Articles on SELE    1. SELP, but not SELE or SELL, are risk factors for age-related macular degeneration; sporadic or rare mutations in SELE, SELL, or SELP may have a role in the pathogenesis of AMD
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SELE antibodyPathways associated with anti-SELE antibody
 Reference Product  PubMed Publications
 SELL antibody  >9 publications with SELE and SELL
 CD44 antibody  >2 publications with SELE and CD44
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Thromboxane A2 Receptor Signaling Pathway antibodies  Thromboxane A2 Receptor Signaling Pathway Diagram
Diseases associated with anti-SELE antibodyOrgans/Tissues associated with anti-SELE antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >31 publications with SELE and Cardiovascular Diseases
 Inflammation Antibodies  >21 publications with SELE and Inflammation
 Neoplasms Antibodies  >20 publications with SELE and Neoplasms
 Immune System Diseases Antibodies  >17 publications with SELE and Immune System Diseases
 Lung Diseases Antibodies  >15 publications with SELE and Lung Diseases
 Skin Diseases Antibodies  >12 publications with SELE and Skin Diseases
 Metabolic Diseases Antibodies  >12 publications with SELE and Metabolic Diseases
 Hypersensitivity Antibodies  >11 publications with SELE and Hypersensitivity
 Respiratory Hypersensitivity Antibodies  >10 publications with SELE and Respiratory Hypersensitivity
 Heart Diseases Antibodies  >10 publications with SELE and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >28 publications with SELE and Vascular
 Lung Antibodies  >10 publications with SELE and Lung
 Liver Antibodies  >5 publications with SELE and Liver
 Brain Antibodies  >5 publications with SELE and Brain
 Testis Antibodies  >5 publications with SELE and Testis
 Heart Antibodies  >5 publications with SELE and Heart
 Uterus Antibodies  >4 publications with SELE and Uterus
 Connective Tissue Antibodies  >3 publications with SELE and Connective Tissue
 Muscle Antibodies  >2 publications with SELE and Muscle
 Thyroid Antibodies  >1 publications with SELE and Thyroid
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