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anti-E2F2 antibody :: Mouse anti-Human E2F2 Transcription Factor Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS601265 anti-E2F2 antibody
Unit / Price
0.05 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

E2F2 Transcription Factor, Monoclonal Antibody

 Also Known As   

E2F2 Transcription Factor

 Product Synonym Names    Anti -E2F2 Transcription Factor
 Product Gene Name   

anti-E2F2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (23832922..23857713, complement). Location: 1p36
 OMIM    600426
 3D Structure    ModBase 3D Structure for Q14209
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    8J109
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human E2F2 Transcription Factor.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 1% BSA, 0.05% sodium azide.
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 Immunogen    Partial sequence of recombinant full-length protein to human E2F2 Transcription Factor
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-E2F2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-E2F2 antibody

   The E2F family of transcription factors plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.
 Product Categories/Family for anti-E2F2 antibody    Antibodies; Abs to Transcription Factors
 Applications Tested/Suitable for anti-E2F2 antibody   

Western Blot (WB), Gel Shift Assay (GS/EMSA)

 Application Notes for anti-E2F2 antibody    Suitable for use in Dot Blot and Western Blot.
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NCBI/Uniprot data below describe general gene information for E2F2. It may not necessarily be applicable to this product.
 NCBI GI #    31657162
 NCBI GeneID    1870
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 UniProt Primary Accession #    Q14209 [Other Products]
 UniProt Secondary Accession #    Q7Z6H1; B2R9W1 [Other Products]
 UniProt Related Accession #    Q14209; Q5U0J0; Q96ID7 [Other Products]
 Molecular Weight    47,506 Da [Similar Products]
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 NCBI Official Full Name    E2F transcription factor 2
 NCBI Official Synonym Full Names    E2F transcription factor 2
 NCBI Official Symbol    E2F2 [Similar Products]
 NCBI Official Synonym Symbols   
E2F-2
[Similar Products]
 NCBI Protein Information    transcription factor E2F2; OTTHUMP00000003257
 UniProt Protein Name    Transcription factor E2F2
 Protein Family    Transcription factor
 UniProt Gene Name    E2F2 [Similar Products]
 UniProt Entry Name    E2F2_HUMAN
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 NCBI Summary for E2F2    The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq]
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 UniProt Comments for E2F2    E2F2: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner. Belongs to the E2F/DP family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: nucleoplasm; transcription factor complex

Molecular Function: protein binding; DNA binding; transcription factor binding; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; regulation of cell cycle; mitotic cell cycle
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 Research Articles on E2F2    1. the 3'UTR of E2F2 and CCND2 were directly bound to let-7a and let-7a down-regulated the expression of E2F2 and CCND2, suppressing prostate cancer cell proliferation in culture
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-E2F2 antibodyPathways associated with anti-E2F2 antibody
 Reference Product  PubMed Publications
 E2F1 antibody  >152 publications with E2F2 and E2F1
 E2F4 antibody  >64 publications with E2F2 and E2F4
 TFDP1 antibody  >13 publications with E2F2 and TFDP1
 RBL1 antibody  >7 publications with E2F2 and RBL1
 SP1 antibody  >7 publications with E2F2 and SP1
 RBL2 antibody  >7 publications with E2F2 and RBL2
 RB1 antibody  >5 publications with E2F2 and RB1
 CDC25A antibody  >5 publications with E2F2 and CDC25A
 CDC6 antibody  >3 publications with E2F2 and CDC6
 TFDP2 antibody  >3 publications with E2F2 and TFDP2
 Products by Pathway  Pathway Diagram
 Assembly Of The Pre-replicative Complex Pathway antibodies  Assembly Of The Pre-replicative Complex Pathway Diagram
 Association Of Licensing Factors With The Pre-replicative Complex Pathway antibodies  Association Of Licensing Factors With The Pre-replicative Complex Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 CDC6 Association With The ORC:origin Complex Pathway antibodies  CDC6 Association With The ORC:origin Complex Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
Diseases associated with anti-E2F2 antibodyOrgans/Tissues associated with anti-E2F2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >69 publications with E2F2 and Neoplasms
 Cell Transformation, Neoplastic Antibodies  >12 publications with E2F2 and Cell Transformation, Neoplastic
 Skin Diseases Antibodies  >11 publications with E2F2 and Skin Diseases
 Breast Neoplasms Antibodies  >9 publications with E2F2 and Breast Neoplasms
 Glioma Antibodies  >9 publications with E2F2 and Glioma
 Ovarian Neoplasms Antibodies  >8 publications with E2F2 and Ovarian Neoplasms
 Colorectal Neoplasms Antibodies  >7 publications with E2F2 and Colorectal Neoplasms
 Nervous System Diseases Antibodies  >7 publications with E2F2 and Nervous System Diseases
 Adenocarcinoma Antibodies  >7 publications with E2F2 and Adenocarcinoma
 Leukemia Antibodies  >5 publications with E2F2 and Leukemia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >24 publications with E2F2 and Blood
 Eye Antibodies  >17 publications with E2F2 and Eye
 Liver Antibodies  >13 publications with E2F2 and Liver
 Bone Antibodies  >12 publications with E2F2 and Bone
 Muscle Antibodies  >11 publications with E2F2 and Muscle
 Embryonic Tissue Antibodies  >11 publications with E2F2 and Embryonic Tissue
 Brain Antibodies  >8 publications with E2F2 and Brain
 Lung Antibodies  >8 publications with E2F2 and Lung
 Heart Antibodies  >6 publications with E2F2 and Heart
 Skin Antibodies  >6 publications with E2F2 and Skin
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