NP_004082.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,506 Da
NCBI Official Full Name
Homo sapiens E2F transcription factor 2 (E2F2), mRNA
NCBI Official Synonym Full Names
E2F transcription factor 2
NCBI Official Synonym Symbols
NCBI Protein Information
transcription factor E2F2
UniProt Protein Name
Transcription factor E2F2
UniProt Entry Name
E2F2_HUMAN
NCBI Summary for E2F2
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008]
UniProt Comments for E2F2
E2F2: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner. Belongs to the E2F/DP family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 1p36
Cellular Component: nucleoplasm; transcription factor complex
Molecular Function: protein binding; DNA binding; transcription factor activity; transcription factor binding
Biological Process: transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; regulation of cell cycle; mitotic cell cycle
Research Articles on E2F2
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Products associated with anti-E2F2 antibody
Pathways associated with anti-E2F2 antibody
Diseases associated with anti-E2F2 antibody
Organs/Tissues associated with anti-E2F2 antibody
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