NP_004161
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
excitatory amino acid transporter 3
NCBI Official Synonym Full Names
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
NCBI Protein Information
excitatory amino acid transporter 3; excitatory amino acid carrier 1; solute carrier family 1 member 1; neuronal and epithelial glutamate transporter; sodium-dependent glutamate/aspartate transporter 3
UniProt Protein Name
Excitatory amino acid transporter 3
UniProt Synonym Protein Names
Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1
UniProt Synonym Gene Names
UniProt Entry Name
EAA3_HUMAN
NCBI Summary for SLC1A1
This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]
UniProt Comments for SLC1A1
SLC1A1: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A1 subfamily.
Protein type: Membrane protein, multi-pass; Transporter; Transporter, SLC family; Membrane protein, integral
Chromosomal Location of Human Ortholog: 9p24
Cellular Component: membrane; integral to plasma membrane; apical plasma membrane; plasma membrane
Molecular Function: glutamate binding; cysteine transmembrane transporter activity; glutamate:sodium symporter activity; sodium:dicarboxylate symporter activity; L-glutamate transmembrane transporter activity
Biological Process: synaptic transmission; L-glutamate import; cysteine transport; ion transport; transmembrane transport; protein homooligomerization
Disease: Schizophrenia 18
Product References and Citations for anti-SLC1A1 antibody
1. Smith C. P., et al., (1994) Genomics 20:335-336. 2. Kanai Y., and Hediger M. A. (1992) Nature 360:467-471.
Research Articles on SLC1A1
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Products associated with anti-SLC1A1 antibody
Pathways associated with anti-SLC1A1 antibody
Diseases associated with anti-SLC1A1 antibody
Organs/Tissues associated with anti-SLC1A1 antibody
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