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anti-ESR2 antibody :: Mouse anti-Human ER-beta1 (Estrogen Receptor beta-1) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS439629
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
7 ml (Prediluted)  /  $270 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ER-beta1 (Estrogen Receptor beta-1) (ESR2), Monoclonal Antibody

★Popular Item★
 Also Known As   

ER-beta1 (Estrogen Receptor beta-1) Mouse Monoclonal Antibody

 Product Synonym Names    Erb, ESR BETA, ESR2, ESRB, ESTRB, estrogen nuclear receptor beta variant a, estrogen nuclear receptor beta variant b, estrogen receptor 2 (ER beta), estrogen receptor beta 4
 Product Gene Name   

anti-ESR2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601663
 3D Structure    ModBase 3D Structure for Q92731
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    ESR2/686
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Cellular Localization    Predominantly nuclear
 Immunogen    C-terminus fragment of recombinant human estrogen receptor beta protein
 Hu-Chromosome Location    14q23.2
 Positive Control    MCF-7 Cells. Ovarian, Breast, Bladder, Gastric or Salivary carcinoma
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of anti-ESR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ESR2 antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin

 Application Notes for anti-ESR2 antibody    Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
Western Blot (0.5-1ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
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 Immunohistochemistry (IHC) of anti-ESR2 antibody    Formalin-fixed, paraffin-embedded human Bladder Carcinoma stained with ER-beta1 Monoclonal Antibody (ESR2/686).
anti-ESR2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ESR2 antibody    Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with ER-beta1 Monoclonal Antibody (ESR2/686).
anti-ESR2 antibody Immunohistochemistry (IHC) (IHC) image
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 Flow Cytometry (FC/FACS) of anti-ESR2 antibody    Flow Cytometry of human ER beta on BT474 Cells. Black: Cells alone; Grey: Isotype Control; Green: AF488-labeled ER beta1 Monoclonal Antibody (ESR2/686).
anti-ESR2 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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 Immunohistochemistry (IHC) of anti-ESR2 antibody    Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with ER-beta1 Monoclonal Antibody (ESR2/686).
anti-ESR2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ESR2 antibody    Formalin-fixed, paraffin-embedded human Ovarian Carcinoma stained with ER-beta1 Monoclonal Antibody (ESR2/686).
anti-ESR2 antibody Immunohistochemistry (IHC) (IHC) image
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 Flow Cytometry (FC) of anti-ESR2 antibody    Flow Cytometry for human ER-beta on MCF-7 Cells. Black: Cells alone; Green: Isotype Control; Red: PE-labeled ER-beta1 Monoclonal Antibody (ESR2/686).
anti-ESR2 antibody Flow Cytometry (FC) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for ESR2. It may not necessarily be applicable to this product.
 NCBI GI #    94538325
 NCBI GeneID    2100
 NCBI Accession #    NP_001035365.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001040275.1 [Other Products]
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 UniProt Primary Accession #    Q92731 [Other Products]
 UniProt Secondary Accession #    O60608; O60685; O60702; O60703; O75583; O75584; Q0MWT5; Q0MWT6; Q86Z31; A8K8K5; G3V5M5 [Other Products]
 UniProt Related Accession #    Q92731 [Other Products]
 Molecular Weight    53-59kDa
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 NCBI Official Full Name    estrogen receptor beta isoform 2
 NCBI Official Synonym Full Names    estrogen receptor 2
 NCBI Official Symbol    ESR2 [Similar Products]
 NCBI Official Synonym Symbols   
Erb; ESRB; ESTRB; NR3A2; ER-BETA; ESR-BETA
[Similar Products]
 NCBI Protein Information    estrogen receptor beta
 UniProt Protein Name    Estrogen receptor beta
 UniProt Synonym Protein Names   
Nuclear receptor subfamily 3 group A member 2
 Protein Family    Estrogen receptor
 UniProt Gene Name    ESR2 [Similar Products]
 UniProt Synonym Gene Names    ESTRB; NR3A2; ER-beta [Similar Products]
 UniProt Entry Name    ESR2_HUMAN
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 NCBI Summary for ESR2    This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ESR2    ER-beta: a nuclear hormone receptor and transcription factor. Binds and activated by estrogen. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Eight alternatively-spliced isoforms have been described. Isoform beta-cx lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 14q23.2

Cellular Component: mitochondrion; nucleoplasm; nucleus

Molecular Function: DNA binding; enzyme binding; estrogen receptor activity; estrogen response element binding; protein binding; steroid binding; steroid hormone receptor activity; transcription coactivator activity; transcription factor activity

Biological Process: cell-cell signaling; estrogen receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; signal transduction; transcription initiation from RNA polymerase II promoter
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Product References and Citations for anti-ESR2 antibody

   Skliris GP et. al. J Pathol 2002;197:155-62.
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 Research Articles on ESR2    1. The expression of ERalpha and ERbeta was inversely correlated with menopausal age. No significant association was observed between ERs or PR expression and benign or malignant endometrial pathology.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ESR2 antibodyPathways associated with anti-ESR2 antibody
 Reference Product  PubMed Publications
 ESR1 antibody  >364 publications with ESR2 and ESR1
 SRC antibody  >7 publications with ESR2 and SRC
 FOS antibody  >4 publications with ESR2 and FOS
 NOS3 antibody  >2 publications with ESR2 and NOS3
 NCOA1 antibody  >2 publications with ESR2 and NCOA1
 NCOA3 antibody  >2 publications with ESR2 and NCOA3
 NCOR2 antibody  >1 publications with ESR2 and NCOR2
 NR0B1 antibody  >1 publications with ESR2 and NR0B1
 NCOA2 antibody  >1 publications with ESR2 and NCOA2
 Products by Pathway  Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 Ovarian Infertility Genes Pathway antibodies  Ovarian Infertility Genes Pathway Diagram
 Plasma Membrane Estrogen Receptor Signaling Pathway antibodies  Plasma Membrane Estrogen Receptor Signaling Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
Diseases associated with anti-ESR2 antibodyOrgans/Tissues associated with anti-ESR2 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >41 publications with ESR2 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >32 publications with ESR2 and Cardiovascular Diseases
 Carcinoma Antibodies  >26 publications with ESR2 and Carcinoma
 Endometriosis Antibodies  >20 publications with ESR2 and Endometriosis
 Colorectal Neoplasms Antibodies  >19 publications with ESR2 and Colorectal Neoplasms
 Prostatic Neoplasms Antibodies  >18 publications with ESR2 and Prostatic Neoplasms
 Infertility, Female Antibodies  >18 publications with ESR2 and Infertility, Female
 Infertility, Male Antibodies  >15 publications with ESR2 and Infertility, Male
 Adenocarcinoma Antibodies  >13 publications with ESR2 and Adenocarcinoma
 Inflammation Antibodies  >12 publications with ESR2 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >56 publications with ESR2 and Brain
 Testis Antibodies  >34 publications with ESR2 and Testis
 Lung Antibodies  >12 publications with ESR2 and Lung
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