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anti-ETV4 antibody :: Mouse anti-Human ETV4 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS850937
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ETV4, Monoclonal Antibody

 Also Known As   

ETV4 Antibody

 Product Synonym Names    HGK; NIK; PEA3
 Product Gene Name   

anti-ETV4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600711
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 Clonality    Monoclonal
 Clone Number    1A2G3
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
 Concentration    100ug/100ul (lot specific)
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 Immunogen    Purified recombinant fragment of human ETV4 (aa50-109) expressed in E. Coli.
 Species    Mouse IgG1
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 Preparation and Storage    Store at 4 degree C. For long term storage, store at -20 degree C
 Other Notes    Small volumes of anti-ETV4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ETV4 antibody

   Background: ETV4. ets variant gene 4 (E1A enhancer binding protein, E1AF), also known as PEA3. Several members of the Ets gene family are known to encode sequencespecific DNA binding proteins. These include mouse PU.1, mouse and human Ets-1, Drosophila E74, chicken and human Ets-2 and rat GABP-alpha. Each of these proteins recognizes similar motifs in DNA that share a centrally located 5'-GGAA-3' element. For instance, PEA3 binds the motif 5'-AGGAAG-3' (the PEA-3 motif), but does not bind to the sequence 5'-AGGAAC-3', recognized by PU.1, although PU.1 binds equally well to both sequences. It appears that all of the Ets proteins recognize the same central core sequence but that each protein interacts with unique sequences that flank this core. PEA3 is expressed at readily detectable levels in cells of epithelial and fibroblastic origin but is not expressed in hematopoietic cells. This is in contrast to other members of the Ets gene family, such as Ets-1, Ets-2 and Fli-1, each of which is expressed primarily in cells of hematopoietic origin.
 Product Categories/Family for anti-ETV4 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-ETV4 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-ETV4 antibody    WB: 1/500 - 1/2000, ELISA: Propose dilution 1/10000
Not yet tested in other applications. Determining optimal working dilutions by titration test.
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 Testing Data of anti-ETV4 antibody    Figure 1. Western blot analysis using ETV4 mouse mAb against K562 cell lysate (1).
anti-ETV4 antibody Testing Data image
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 Testing Data #2 of anti-ETV4 antibody    Figure 2. Western blot analysis using ETV4 mouse mAb against HEK293T cells transfected with the pCMV6-ENTRY control (1) and pCMV6-ENTRY ETV4 cDNA (2).
anti-ETV4 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for ETV4. It may not necessarily be applicable to this product.
 NCBI GI #    118918421
 NCBI GeneID    2118
 NCBI Accession #    NP_001073143.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001079675.2 [Other Products]
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 UniProt Secondary Accession #    Q96AW9; A8K314; B7Z5J3; B7Z9J6 [Other Products]
 UniProt Related Accession #    P43268 [Other Products]
 Molecular Weight    54kDa
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 NCBI Official Full Name    ETS translocation variant 4 isoform 1
 NCBI Official Synonym Full Names    ets variant 4
 NCBI Official Symbol    ETV4 [Similar Products]
 NCBI Official Synonym Symbols   
E1AF; PEA3; E1A-F; PEAS3
[Similar Products]
 NCBI Protein Information    ETS translocation variant 4; adenovirus E1A enhancer-binding protein; polyomavirus enhancer activator 3 homolog; EWS protein/E1A enhancer binding protein chimera; ets variant gene 4 (E1A enhancer-binding protein, E1AF)
 UniProt Protein Name    ETS translocation variant 4
 UniProt Synonym Protein Names   
Adenovirus E1A enhancer-binding protein; E1A-F; Polyomavirus enhancer activator 3 homolog; Protein PEA3
 Protein Family    ETS translocation
 UniProt Gene Name    ETV4 [Similar Products]
 UniProt Synonym Gene Names    E1AF; PEA3; Protein PEA3 [Similar Products]
 UniProt Entry Name    ETV4_HUMAN
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 UniProt Comments for ETV4    ETV4: Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding sequence is 5'[AC]GGA[AT]GT-3'. Belongs to the ETS family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: nucleolus

Molecular Function: protein binding

Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; motor axon guidance; positive regulation of transcription from RNA polymerase II promoter; stem cell differentiation; cell differentiation; negative regulation of mammary gland epithelial cell proliferation
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 Research Articles on ETV4    1. PEA3 regulates OCT4 gene expression as a transcriptional activator
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ETV4 antibodyPathways associated with anti-ETV4 antibody
 Reference Product  PubMed Publications
 FGF10 antibody  >3 publications with ETV4 and FGF10
 PTGS2 antibody  >3 publications with ETV4 and PTGS2
 MMP14 antibody  >2 publications with ETV4 and MMP14
 MMP9 antibody  >2 publications with ETV4 and MMP9
 ERBB2 antibody  >2 publications with ETV4 and ERBB2
 SP1 antibody  >1 publications with ETV4 and SP1
 Products by Pathway  Pathway Diagram
 LKB1 Signaling Events Pathway antibodies  LKB1 Signaling Events Pathway Diagram
 Prostate Cancer Pathway antibodies  Prostate Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
Diseases associated with anti-ETV4 antibodyOrgans/Tissues associated with anti-ETV4 antibody
 Disease Name  Pubmed Publications
 Prostatic Neoplasms Antibodies  >36 publications with ETV4 and Prostatic Neoplasms
 Carcinoma Antibodies  >31 publications with ETV4 and Carcinoma
 Neoplasm Metastasis Antibodies  >18 publications with ETV4 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >10 publications with ETV4 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >8 publications with ETV4 and Cell Transformation, Neoplastic
 Carcinoma, Squamous Cell Antibodies  >7 publications with ETV4 and Carcinoma, Squamous Cell
 Neoplasms, Experimental Antibodies  >6 publications with ETV4 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >6 publications with ETV4 and Lung Neoplasms
 Kidney Diseases Antibodies  >5 publications with ETV4 and Kidney Diseases
 Disease Models, Animal Antibodies  >5 publications with ETV4 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >44 publications with ETV4 and Prostate
 Kidney Antibodies  >14 publications with ETV4 and Kidney
 Lung Antibodies  >7 publications with ETV4 and Lung
 Bone Antibodies  >7 publications with ETV4 and Bone
 Embryonic Tissue Antibodies  >5 publications with ETV4 and Embryonic Tissue
 Blood Antibodies  >4 publications with ETV4 and Blood
 Mouth Antibodies  >4 publications with ETV4 and Mouth
 Testis Antibodies  >3 publications with ETV4 and Testis
 Stomach Antibodies  >3 publications with ETV4 and Stomach
 Intestine Antibodies  >3 publications with ETV4 and Intestine
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