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anti-EVI1 antibody :: Mouse anti-Human EVI1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120413
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EVI1, Monoclonal Antibody

 Also Known As   

Mouse monoclonal antibody Anti-Human EVI1

 Product Synonym Names    Homo sapiens ecotropic viral integration site 1 (EVI1), mRNA.; EVI-1; PRDM3; MDS1-EVI1; MGC163392;AML1-EVI-1
 Product Gene Name   

anti-EVI1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    165215
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    2331C1a1
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-EVI1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-EVI1 antibody   

Dot Blot (DB)

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 Quality Control of anti-EVI1 antibody    Western blot analysis of immunized recombinant protein, using anti-EVI1 monoclonal antibody.
anti-EVI1 antibody Quality Control image
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 Quality Control #2 of anti-EVI1 antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-EVI1 antibody Quality Control #2 image
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NCBI/Uniprot data below describe general gene information for EVI1. It may not necessarily be applicable to this product.
 NCBI GI #    255683381
 NCBI GeneID    2122
 NCBI Accession #    NP_005232.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005241 [Other Products]
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 UniProt Secondary Accession #    Q16122; Q5HYI1; Q6MZS6; Q8NEI5; A1L4F3; A8KA00; B7Z8W7; B7ZLQ3; B7ZLQ4; C9JAK0; D3DNP7 [Other Products]
 UniProt Related Accession #    Q03112; Q13465 [Other Products]
 Molecular Weight    117,232 Da
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 NCBI Official Full Name    Homo sapiens MDS1 and EVI1 complex locus (MECOM), transcript variant 2, mRNA
 NCBI Official Synonym Full Names    MDS1 and EVI1 complex locus
 NCBI Official Symbol    MECOM [Similar Products]
 NCBI Official Synonym Symbols   
EVI1; MDS1; PRDM3; MDS1-EVI1; AML1-EVI-1
[Similar Products]
 NCBI Protein Information    MDS1 and EVI1 complex locus protein EVI1; AML1-EVI-1 fusion protein; MDS1 and EVI1 complex locus protein MDS1; ecotropic virus integration site 1 protein homolog; myelodysplasia syndrome-associated protein 1; oncogene EVI1; zinc finger protein Evi1
 UniProt Gene Name    MECOM [Similar Products]
 UniProt Entry Name    EVI1_HUMAN
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 NCBI Summary for EVI1    The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
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 UniProt Comments for EVI1    EVI1: a zinc finger transcriptional regulator that binds to DNA sequences in the promoter region of target genes and positively or negatively regulates their expression. An oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. Originally identified as a common site of viral integration in murine myeloid leukemia. Involved in human myeloid disorders through chromosome translocation and inversion and is also implicated in solid tumor formation. At least six isoforms of the human protein are formed due to alternative usage of 5'-ends, alternative splicing, and intergenic splicing which results in the formation of a fusion protein with MDS1, which can be expressed in normal tissues.

Protein type: Oncoprotein; C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted; Transcription, coactivator/corepressor; Transcription regulation

Chromosomal Location of Human Ortholog: 3q26.2

Cellular Component: nucleoplasm; Golgi apparatus; intracellular membrane-bound organelle; histone deacetylase complex; cytoplasm; nuclear speck; nucleus

Molecular Function: protein binding; protein homodimerization activity; DNA binding; metal ion binding; transcription factor activity

Biological Process: embryonic forelimb morphogenesis; negative regulation of JNK cascade; pericardium development; transcription, DNA-dependent; in utero embryonic development; apoptosis; regulation of cell cycle; positive regulation of transcription, DNA-dependent; neutrophil homeostasis; embryonic hindlimb morphogenesis; post-embryonic development; regulation of cell proliferation; response to bacterium; regulation of transcription, DNA-dependent; forebrain development; negative regulation of programmed cell death; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; cell differentiation; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway
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 Research Articles on EVI1    1. Findings suggest that the EVI-1 rs6774494 G > A single nucleotide polymorphism targeted by miRNA-206/133b may contribute to the pathogenesis of breast cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EVI1 antibodyPathways associated with anti-EVI1 antibody
 Reference Product  PubMed Publications
 GATA2 antibody  >13 publications with EVI1 and GATA2
 SMAD3 antibody  >6 publications with EVI1 and SMAD3
 PTEN antibody  >2 publications with EVI1 and PTEN
 PBX1 antibody  >1 publications with EVI1 and PBX1
 Products by Pathway  Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
Diseases associated with anti-EVI1 antibodyOrgans/Tissues associated with anti-EVI1 antibody
 Disease Name  Pubmed Publications
 Leukemia, Myeloid Antibodies  >190 publications with EVI1 and Leukemia, Myeloid
 Leukemia, Lymphoid Antibodies  >24 publications with EVI1 and Leukemia, Lymphoid
 Anemia Antibodies  >11 publications with EVI1 and Anemia
 Breast Neoplasms Antibodies  >7 publications with EVI1 and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >7 publications with EVI1 and Ovarian Neoplasms
 Neoplasms, Experimental Antibodies  >6 publications with EVI1 and Neoplasms, Experimental
 Inflammation Antibodies  >3 publications with EVI1 and Inflammation
 Adenocarcinoma Antibodies  >2 publications with EVI1 and Adenocarcinoma
 Colonic Neoplasms Antibodies  >2 publications with EVI1 and Colonic Neoplasms
 Carcinoma, Squamous Cell Antibodies  >2 publications with EVI1 and Carcinoma, Squamous Cell
 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >61 publications with EVI1 and Bone Marrow
 Kidney Antibodies  >8 publications with EVI1 and Kidney
 Lung Antibodies  >8 publications with EVI1 and Lung
 Brain Antibodies  >4 publications with EVI1 and Brain
 Liver Antibodies  >4 publications with EVI1 and Liver
 Ovary Antibodies  >4 publications with EVI1 and Ovary
 Prostate Antibodies  >4 publications with EVI1 and Prostate
 Embryonic Tissue Antibodies  >2 publications with EVI1 and Embryonic Tissue
 Bladder Antibodies  >2 publications with EVI1 and Bladder
 Skin Antibodies  >1 publications with EVI1 and Skin
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