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anti-GP antibody :: Mouse Ebola GP I Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS668203
Western Blot (WB)
Unit / Price
0.025 mg  /  $145 +1 FREE 8GB USB
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ebola GP I, Monoclonal Antibody

★Popular Item★
 Also Known As   

Ebola GP I; GP

 Product Gene Name   

anti-GP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q7T9D9
 Clonality    Monoclonal
 Isotype    IgG2b, Kappa
 Clone Number    ABM47F9
 Host    Mouse
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 Purity/Purification    Protein G Chromatography
 Form/Format    Purified
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 Immunogen    A partial length recombinant GP I protein of Sudan Ebola virus was used as an immunogen for this antibody.
 Content    25ug in 50ul/100ug in 200ul PBS containing 0.05% BSA and 0.05% sodium azide.Sodium azide is highly toxic.
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 Preparation and Storage    Store the antibody at 4 degree C, stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles.
 Other Notes    Small volumes of anti-GP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GP antibody

   The Sudan ebola virus (SUDV) glycoprotein (GP) is an envelope glycoprotein that is present on the virion surface and is involved in receptor binding and mediating viral entry. It is composed of a trimer of heterodimers (GP1/GP2), where GP1 and GP2 remain covalently linked by a disulfide bond9, and the resulting GP1-GP2 pair trimerizes to form a ~450 kDa envelope spike on the viral surface. GP is synthesized as a single polypeptide of 676 amino acids in length that is post-translationally cleaved by furin to yield two subunits, GP1 and GP2. The GP1 subunit contains two heavily glycosylated domains, the glycan cap and the mucin-like domain (MLD). The glycan cap contains only N-linked glycans, whereas the MLD contains both N- and O-linked glycans. All 15 N-glycosylation sites of GP1 could be removed without compromising the expression of GP. In the endosome, a flexible loop containing GP1 residues 190 213 is cleaved by host cathepsins. This cleavage releases the glycan ap and mucin-like domains from GP1. The GP1 subunit is responsible for receptor binding and attachment to new host cells.
 Applications Tested/Suitable for anti-GP antibody   

Western Blot (WB)

 Application Notes for anti-GP antibody    Western Blot analysis: 0.5-1ug/ml
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 Western Blot (WB) of anti-GP antibody    Western Blot analysis of Ebola GP I. Anti-Ebola GP I antibody (Clone: ABM47F9) was tested at 0.1 ug/ml partial length recombinant protein.
anti-GP antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for GP. It may not necessarily be applicable to this product.
 NCBI GI #    55770812
 NCBI GeneID    3160774
 NCBI Accession #    YP_138523.1 [Other Products]
 NCBI GenBank Nucleotide #    NC_006432.1 [Other Products]
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 UniProt Primary Accession #    Q7T9D9 [Other Products]
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 NCBI Official Full Name    spike glycoprotein
 NCBI Official Symbol    GP [Similar Products]
 NCBI Protein Information    spike glycoprotein; small secreted glycoprotein; second secreted glycoprotein
 UniProt Protein Name    Envelope glycoprotein
 UniProt Synonym Protein Names   
GP1,2; GP
 Protein Family    Envelopment polyprotein
 UniProt Gene Name    GP [Similar Products]
 UniProt Synonym Gene Names    GP [Similar Products]
 UniProt Entry Name    VGP_EBOSU
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 UniProt Comments for GP    GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. Binding to CD209 and CLEC4M, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses, facilitate infection of macrophages and endothelial cells. These interactions not only facilitate virus cell entry, but also allow capture of viral particles by DCs and subsequent transmission to susceptible cells without DCs infection (trans infection). Binding to the macrophage specific lectin CLEC10A also seem to enhance virus infectivity. Interaction with FOLR1/folate receptor alpha may be a cofactor for virus entry in some cell types, although results are contradictory. Members of the Tyro3 receptor tyrosine kinase family also seem to be cell entry factors in filovirus infection. Once attached, the virions are internalized through clathrin-dependent endocytosis and/or macropinocytosis. After internalization of the virus into the endosomes of the host cell, proteolysis of GP1 by two cysteine proteases, CTSB/cathepsin B and CTSL/cathepsin L presumably induces a conformational change of GP2, allowing its binding to the host entry receptor NPC1 and unmasking its fusion peptide to initiate membranes fusion.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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