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anti-PI3 antibody :: Mouse anti-Human Elafin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS605154 anti-PI3 antibody
Unit / Price
0.1 mg  /  $940 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Elafin (PI3), Monoclonal Antibody

 Also Known As   

Elafin (SKALP, ESI, ELAFIN, Elafin precursor, Elastase-specific inhibitor, ESI, MGC13613, Peptidase inhibitor 3, Protease inhibitor WAP3, SKALP, Skin-derived antileukoproteinase, WAP3, WAP four-disulfide core domain protein 14, WFDC14)

 Product Synonym Names    Anti -Elafin (SKALP, ESI, ELAFIN, Elafin precursor, Elastase-specific inhibitor, ESI, MGC13613, Peptidase inhibitor 3, Protease inhibitor WAP3, SKALP, Skin-derived antileukoproteinase, WAP3, WAP four-disulfide core domain protein 14, WFDC14)
 Product Gene Name   

anti-PI3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 20; NC_000020.10 (43803540..43805185). Location: 20q13.12
 OMIM    182257
 3D Structure    ModBase 3D Structure for P19957
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    9G181
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human native full-length Elafin. Weakly recognizes fully processed Elafin (C-terminal 57aa). Recognizes all known Trappins via the GQDPVK epitope. Cross reacts with Trappin family members of other species with GQDPVK epitope. For detection of fully processed Elafin (C-terminal 57aa) use E2225-01.
 Purity/Purification    Affinity Purified
Purified
 Form/Format    Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.
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 Immunogen    Human Elafin/SKALP
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-PI3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PI3 antibody

   Elafin is an epithelial proteinase inhibitor also known under various other names such as Skin-derived Anti leukoproteinase (SKALP) and Elastase-Specific Inhibitor (ESI). Elafin belongs to the Trappin gene family and was given the systematic name Trappin-2. The Trappin family is defined by a N-terminal transglutaminase substrate domain and a C-terminal four disulfide core. Trappins have been suggested to play a role in the regulation of inflammation and in protection against tissue damage in stratified epithelia. Elafin is an inhibitor of leukocyte elastase and proteinase-3 and is a substrate for transglutaminases. The protein is constitutively expressed in various epithelia including hair follicles, oesophagus, vagina and oral cavity. Elafin is not present in normal human skin but is strongly induced during inflammation as in psoriasis and wound healing. Antibodies to Elafin can be used to evaluate the effects of treatment of psoriasis since its expression is significantly correlated with clinical scores. Antibodies to Elafin have also been succesfully used to study differentiation in squamous cell carcinoma of the head-and-neck region, oesophagus and skin. It is also shown that Elafin possesses antimicrobial activity against gram-positive and gram-negative bacteria.
 Product Categories/Family for anti-PI3 antibody    Antibodies; Abs to Proteins
 Applications Tested/Suitable for anti-PI3 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-PI3 antibody    Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: Western Blot: 1:10 Non-reduced conditions recommended.
Immunohistochemistry (paraffin): 1:10
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NCBI/Uniprot data below describe general gene information for PI3. It may not necessarily be applicable to this product.
 NCBI GI #    4505787
 NCBI GeneID    5266
 NCBI Accession #    NP_002629.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002638.3 [Other Products]
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 UniProt Primary Accession #    P19957 [Other Products]
 UniProt Secondary Accession #    Q6FG74; E1P618 [Other Products]
 UniProt Related Accession #    P19957; Q6LD69 [Other Products]
 Molecular Weight    12,270 Da [Similar Products]
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 NCBI Official Full Name    elafin preproprotein
 NCBI Official Synonym Full Names    peptidase inhibitor 3, skin-derived
 NCBI Official Symbol    PI3 [Similar Products]
 NCBI Official Synonym Symbols   
ESI; WAP3; SKALP; WFDC14; MGC13613; cementoin
[Similar Products]
 NCBI Protein Information    elafin; PI-3; trappin-2; pre-elafin; OTTHUMP00000031100; protease inhibitor WAP3; elastase-specific inhibitor; skin-derived antileukoproteinase; WAP four-disulfide core domain 14; WAP four-disulfide core domain protein 14; protease inhibitor 3, skin-derived (SKALP)
 UniProt Protein Name    Elafin
 UniProt Synonym Protein Names   
Elastase-specific inhibitor; ESI; Peptidase inhibitor 3; PI-3; Protease inhibitor WAP3; Skin-derived antileukoproteinase; SKALP; WAP four-disulfide core domain protein 14
 Protein Family    Elafin
 UniProt Gene Name    PI3 [Similar Products]
 UniProt Synonym Gene Names    WAP3; WFDC14 [Similar Products]
 UniProt Entry Name    ELAF_HUMAN
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 NCBI Summary for PI3    This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq]
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 UniProt Comments for PI3    elafin: Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.

Protein type: Secreted, signal peptide; Secreted; Extracellular matrix; Inhibitor

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: proteinaceous extracellular matrix

Molecular Function: serine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity

Biological Process: copulation
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 Research Articles on PI3    1. these results collectively suggest that, in melanoma cells, Foxa2 expression is silenced and therefore elafin is maintained unexpressed to facilitate cell proliferation in the disease melanoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-PI3 antibodyOrgans/Tissues associated with anti-PI3 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >155 publications with PI3 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >110 publications with PI3 and Cell Transformation, Neoplastic
 Lymphoma Antibodies  >62 publications with PI3 and Lymphoma
 Arthritis, Rheumatoid Antibodies  >22 publications with PI3 and Arthritis, Rheumatoid
 Abnormalities, Drug-Induced Antibodies  >10 publications with PI3 and Abnormalities, Drug-Induced
 Psoriasis Antibodies  >8 publications with PI3 and Psoriasis
 Liver Cirrhosis Antibodies  >8 publications with PI3 and Liver Cirrhosis
 Cystic Fibrosis Antibodies  >6 publications with PI3 and Cystic Fibrosis
 Renal Insufficiency Antibodies  >2 publications with PI3 and Renal Insufficiency
 Lung Diseases, Interstitial Antibodies  >2 publications with PI3 and Lung Diseases, Interstitial
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >767 publications with PI3 and Blood
 Muscle Antibodies  >572 publications with PI3 and Muscle
 Brain Antibodies  >419 publications with PI3 and Brain
 Lung Antibodies  >173 publications with PI3 and Lung
 Prostate Antibodies  >85 publications with PI3 and Prostate
 Intestine Antibodies  >77 publications with PI3 and Intestine
 Skin Antibodies  >67 publications with PI3 and Skin
 Adipose Tissue Antibodies  >54 publications with PI3 and Adipose Tissue
 Ovary Antibodies  >48 publications with PI3 and Ovary
 Thyroid Antibodies  >39 publications with PI3 and Thyroid
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