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anti-ELN antibody :: Mouse anti-Human Elastin (ELN) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2012716 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.2 mg  /  $360 +1 FREE 8GB USB
0.5 mg  /  $690 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Elastin (ELN), Monoclonal Antibody

★Popular Item★
 Also Known As   

Monoclonal Antibody to Elastin (ELN)

 Product Gene Name   

anti-ELN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 7; NC_000007.13 (73442119..73484237). Location: 7q11.23
 OMIM    123700
 3D Structure    ModBase 3D Structure for P15502
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 Clonality    Monoclonal
 Isotype    IgG2b Kappa
 Clone Number    C3
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    Protein A/G Affinity Chromatography
 Form/Format    Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
 Concentration    500ug/ml (lot specific)
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 Source    Monoclonal antibody preparation
 Traits    Liquid
 Immunogen    Recombinant ELN (Gly392~Ala645) expressed in E.coli
    
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-ELN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ELN antibody   

WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM

 Application Notes for anti-ELN antibody    Western blotting: 0.5-5ug/ml
Immunocytochemistry in formalin fixed cells: 5-30ug/ml
Immunohistochemistry in formalin fixed frozen section: 5-30ug/ml
Immunohistochemistry in paraffin section: 5-30ug/ml
Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml

Optimal working dilutions must be determined by end user
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 Western Blot of anti-ELN antibody    Western Blot
Sample: Recombinant ELN, Human
anti-ELN antibody Western Blot (WB) image
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 Immunohistochemistry of anti-ELN antibody    anti-ELN antibody Immunohistochemistry (IHC) image
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NCBI/Uniprot data below describe general gene information for ELN. It may not necessarily be applicable to this product.
 NCBI GI #    525313599
 NCBI GeneID    2006
 NCBI Accession #    NP_001265868.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001278939.1 [Other Products]
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 UniProt Primary Accession #    P15502 [Other Products]
 UniProt Secondary Accession #    O15336; O15337; Q14233; Q14234; Q14235; Q14238; Q6P0L4; Q6ZWJ6; Q75MU5; Q7Z316; B3KTS6 [Other Products]
 UniProt Related Accession #    P15502 [Other Products]
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 NCBI Official Full Name    elastin isoform m
 NCBI Official Synonym Full Names    elastin
 NCBI Official Symbol    ELN [Similar Products]
 NCBI Official Synonym Symbols   
WS; WBS; SVAS
[Similar Products]
 NCBI Protein Information    elastin; tropoelastin
 UniProt Protein Name    Elastin
 UniProt Synonym Protein Names   
Tropoelastin
 Protein Family    Elastin
 UniProt Gene Name    ELN [Similar Products]
 UniProt Entry Name    ELN_HUMAN
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 NCBI Summary for ELN    This gene encodes a protein that is one of the two components of elastic fibers. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ELN    elastin: Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle. Defects in ELN are the cause of cutis laxa, autosomal dominant, type 1 (ADCL1). A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. Additional variable clinical features are gastrointestinal diverticula, hernia, and genital prolapse. Rare manifestations are pulmonary artery stenosis, aortic aneurysm, bronchiectasis, and emphysema. Defects in ELN are the cause of supravalvular aortic stenosis (SVAS). SVAS is a congenital narrowing of the ascending aorta which can occur sporadically, as an autosomal dominant condition, or as one component of Williams-Beuren syndrome. ELN is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of ELN may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. Belongs to the elastin family. 13 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Extracellular matrix; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: proteinaceous extracellular matrix; extracellular region

Molecular Function: protein binding; extracellular matrix structural constituent

Biological Process: extracellular matrix disassembly; cell proliferation; organ morphogenesis; extracellular matrix organization and biogenesis; blood circulation; respiratory gaseous exchange

Disease: Cutis Laxa, Autosomal Dominant 1; Williams-beuren Syndrome; Supravalvular Aortic Stenosis
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 Research Articles on ELN    1. Elastin binding protein and FKBP65 modulate the kinetics of self-assembly of tropoelastin in an in vitro system.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ELN antibodyDiseases associated with anti-ELN antibody
 Products by Pathway  Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >88 publications with ELN and Heart Diseases
 Aortic Stenosis, Supravalvular Antibodies  >68 publications with ELN and Aortic Stenosis, Supravalvular
 Nervous System Diseases Antibodies  >65 publications with ELN and Nervous System Diseases
 Williams Syndrome Antibodies  >61 publications with ELN and Williams Syndrome
 Neoplasms Antibodies  >42 publications with ELN and Neoplasms
 Hypertension Antibodies  >19 publications with ELN and Hypertension
 Disease Models, Animal Antibodies  >16 publications with ELN and Disease Models, Animal
 Cutis Laxa Antibodies  >10 publications with ELN and Cutis Laxa
 Heart Defects, Congenital Antibodies  >10 publications with ELN and Heart Defects, Congenital
 Hypertrophy Antibodies  >8 publications with ELN and Hypertrophy
Organs/Tissues associated with anti-ELN antibody
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >58 publications with ELN and Vascular
 Muscle Antibodies  >47 publications with ELN and Muscle
 Heart Antibodies  >41 publications with ELN and Heart
 Connective Tissue Antibodies  >23 publications with ELN and Connective Tissue
 Lung Antibodies  >22 publications with ELN and Lung
 Brain Antibodies  >22 publications with ELN and Brain
 Skin Antibodies  >20 publications with ELN and Skin
 Bone Antibodies  >17 publications with ELN and Bone
 Intestine Antibodies  >13 publications with ELN and Intestine
 Eye Antibodies  >10 publications with ELN and Eye
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