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anti-TXNDC5 antibody :: Mouse anti-Human EndoPDI Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS804355 anti-TXNDC5 antibody
Unit / Price
0.1 mg  /  $435 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EndoPDI (TXNDC5), Monoclonal Antibody

 Also Known As   

EndoPDI Antibody: Biotin

 Product Synonym Names    TXNDC5; Thioredoxin domain containing 5; ERP46; UNQ364; MGC3178; FLJ21353; FLJ90810; thioredoxin related protein; endothelial protein disulphide isomeras
 Product Gene Name   

anti-TXNDC5 antibody

[Similar Products]
 Matching Pairs    Unconjugated Antibody: EndoPDI Clone #2E7/7 (MBS800813)
Biotin Conjugated Antibody: EndoPDI Clone #2E7/7 (MBS804355)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q8NBS9
 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    2E7/7
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Protein G Purified
 Concentration    1mg/mL (lot specific)
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 Conjugate    Biotin
 Storage Buffer    PBS pH7.4, 50% glyercol, 0.09% sodium azide
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 Preparation and Storage    -20 degree C
 Other Notes    Small volumes of anti-TXNDC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TXNDC5 antibody

   Background Info: Detects a protein with a mass of ~48kDa corresponding to EndoPDI

Scientific Background: Endothelial protein disulfide isomerase (EndoPDI) is a thioredoxin member of the protein disulfide isomerase family of chaperones. This enzyme has been localized to the endoplasmic reticulum in primary endothelial cells, but colocalizes with nucleoli in the nuclei of breast, colon, and renal cancer cells. EndoPDI mRNA and protein expression is induced by hypoxia and exhibits a protective effect on endothelial cells during hypoxia (1).
 Product Categories/Family for anti-TXNDC5 antibody    Chaperones, Organelle Markers
 Applications Tested/Suitable for anti-TXNDC5 antibody   

ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-TXNDC5 antibody    1:200 (WB)
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NCBI/Uniprot data below describe general gene information for TXNDC5. It may not necessarily be applicable to this product.
 NCBI GI #    224493972
 NCBI GeneID    81567
 NCBI Accession #    NP_001139021 [Other Products]
 NCBI GenBank Nucleotide #    NM_001145549.2 [Other Products]
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 UniProt Primary Accession #    Q8NBS9 [Other Products]
 UniProt Secondary Accession #    Q5TCQ0; Q8ND33; Q8TCT2; Q9BVH9; B2RDM2 [Other Products]
 UniProt Related Accession #    Q8NBS9 [Other Products]
 Molecular Weight    36,178 Da [Similar Products]
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 NCBI Official Full Name    thioredoxin domain-containing protein 5 isoform 3
 NCBI Official Synonym Full Names    thioredoxin domain containing 5 (endoplasmic reticulum)
 NCBI Official Symbol    TXNDC5 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    thioredoxin domain-containing protein 5; ER protein 46; thioredoxin related protein; thioredoxin-like protein p46; endoplasmic reticulum protein ERp46; endothelial protein disulphide isomerase; endoplasmic reticulum resident protein 46; protein disulfide isomerase family A, member 15
 UniProt Protein Name    Thioredoxin domain-containing protein 5
 UniProt Synonym Protein Names   
Endoplasmic reticulum resident protein 46; ER protein 46; ERp46; Thioredoxin-like protein p46
 Protein Family    Thioredoxin domain-containing protein
 UniProt Gene Name    TXNDC5 [Similar Products]
 UniProt Synonym Gene Names    TLP46; UNQ364/PRO700; ER protein 46; ERp46 [Similar Products]
 UniProt Entry Name    TXND5_HUMAN
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 NCBI Summary for TXNDC5    This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene. [provided by RefSeq, Dec 2010]
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 UniProt Comments for TXNDC5    TXNDC5: Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide- isomerase deficiency in yeast. Belongs to the protein disulfide isomerase family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6p24.3

Cellular Component: lysosomal lumen; endoplasmic reticulum lumen; endoplasmic reticulum

Molecular Function: protein binding; protein disulfide isomerase activity

Biological Process: protein folding; cell redox homeostasis; post-Golgi vesicle-mediated transport; apoptotic cell clearance; negative regulation of apoptosis
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Product References and Citations for anti-TXNDC5 antibody

   1. Sullivan D.C., et al. (2003) J Biol Chem. 278 (47) 47079-47088.
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 Research Articles on TXNDC5    1. Endo-PDI is a novel, important mediator of AP-1-driven gene expression and endothelial angiogenic function.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-TXNDC5 antibodyDiseases associated with anti-TXNDC5 antibody
 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 Lysosome Vesicle Biogenesis Pathway antibodies  Lysosome Vesicle Biogenesis Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Trans-Golgi Network Vesicle Budding Pathway antibodies  Trans-Golgi Network Vesicle Budding Pathway Diagram
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >5 publications with TXNDC5 and Liver Diseases
 Immune System Diseases Antibodies  >4 publications with TXNDC5 and Immune System Diseases
 Liver Neoplasms Antibodies  >4 publications with TXNDC5 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >3 publications with TXNDC5 and Carcinoma, Hepatocellular
 Arthritis, Rheumatoid Antibodies  >3 publications with TXNDC5 and Arthritis, Rheumatoid
 Inflammation Antibodies  >2 publications with TXNDC5 and Inflammation
 Weight Loss Antibodies  >1 publications with TXNDC5 and Weight Loss
 Atherosclerosis Antibodies  >1 publications with TXNDC5 and Atherosclerosis
 Fatty Liver Antibodies  >1 publications with TXNDC5 and Fatty Liver
 Necrosis Antibodies  >1 publications with TXNDC5 and Necrosis
Organs/Tissues associated with anti-TXNDC5 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >6 publications with TXNDC5 and Liver
 Blood Antibodies  >5 publications with TXNDC5 and Blood
 Stomach Antibodies  >3 publications with TXNDC5 and Stomach
 Lung Antibodies  >3 publications with TXNDC5 and Lung
 Bone Antibodies  >2 publications with TXNDC5 and Bone
 Vascular Antibodies  >2 publications with TXNDC5 and Vascular
 Uterus Antibodies  >1 publications with TXNDC5 and Uterus
 Placenta Antibodies  >1 publications with TXNDC5 and Placenta
 Pancreas Antibodies  >1 publications with TXNDC5 and Pancreas
 Brain Antibodies  >1 publications with TXNDC5 and Brain
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