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anti-COL18A1 antibody :: Mouse Endostatin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS533678
ELISA (EIA)
Unit / Price
0.1 mg  /  $305 +1 FREE 8GB USB
1 mg  /  $1,275 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Endostatin (COL18A1), Monoclonal Antibody

★Popular Item★
 Also Known As   

Endostatin antibody

 Product Synonym Names    Monoclonal Endostatin; Anti-Endostatin
 Product Gene Name   

anti-COL18A1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    120328
 3D Structure    ModBase 3D Structure for P39060
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    KT58
 Host    Mouse
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 Specificity    Human
 Purity/Purification    Endostatin antibody was purified by Protein A chromatography.
 Form/Format    Supplied in PBS containing 0.1% sodium azide as a preservative
 Concentration    1 mg/ml (lot specific)
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 Biological Significance    Endostatin is a naturally occurring 20 kDa polypeptide derived from the C-terminal portion of type XVIII collagen. It functions as an anti-angiogenic cytokine that is expressed in various organs with the highest levels in liver, lung and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF basic.
 Biohazard Information    This product contains sodium azide which is hazardous
 Immunogen    Endostatin antibody was raised in Mouse using recombinant endostatin as the immunogen.
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 Preparation and Storage    Store at 4 degree C for up to 1 month. For long term storage, aliquot and store at -20 to -80 degree C. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-COL18A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-COL18A1 antibody

   Mouse monoclonal Endostatin antibody
 Product Categories/Family for anti-COL18A1 antibody    Cytokines & Growth Factors
 Applications Tested/Suitable for anti-COL18A1 antibody   

ELISA (EIA)

 Application Notes for anti-COL18A1 antibody    ELISA: 1 ug/ml
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 ELISA (EIA) of anti-COL18A1 antibody    Sandwich ELISA using antibody Clone KT58 coated plate and HRP conjugated antibody Clone KT60
anti-COL18A1 antibody ELISA (EIA) image
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NCBI/Uniprot data below describe general gene information for COL18A1. It may not necessarily be applicable to this product.
 NCBI GI #    13957730
 NCBI GeneID    80781
 NCBI Accession #    AAK50626.1 [Other Products]
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 UniProt Primary Accession #    P39060 [Other Products]
 UniProt Secondary Accession #    Q58EX6; Q6RZ39; Q6RZ40; Q6RZ41; Q8N4S4; Q8WXI5; Q96T70; Q9UK38; Q9Y6Q7; Q9Y6Q8; A8MVI4 [Other Products]
 UniProt Related Accession #    P39060 [Other Products]
 Molecular Weight    135,761 Da [Similar Products]
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 NCBI Official Full Name    endostatin variant, partial
 NCBI Official Synonym Full Names    collagen, type XVIII, alpha 1
 NCBI Official Symbol    COL18A1 [Similar Products]
 NCBI Official Synonym Symbols   
KS; KNO; KNO1
[Similar Products]
 NCBI Protein Information    collagen alpha-1(XVIII) chain
 UniProt Protein Name    Collagen alpha-1(XVIII) chain
 Protein Family    Collagen
 UniProt Gene Name    COL18A1 [Similar Products]
 UniProt Entry Name    COIA1_HUMAN
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 NCBI Summary for COL18A1    This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
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 UniProt Comments for COL18A1    COL18A1: COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Defects in COL18A1 are a cause of Knobloch syndrome type 1 (KNO1). An autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele. Belongs to the multiplexin collagen family. 3 isoforms of the human protein are produced by alternative promoter.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: extracellular matrix; extracellular space; collagen; endoplasmic reticulum lumen; extracellular region; basement membrane

Molecular Function: identical protein binding; protein binding; metal ion binding; structural molecule activity

Biological Process: response to drug; collagen catabolic process; extracellular matrix disassembly; negative regulation of cell proliferation; organ morphogenesis; extracellular matrix organization and biogenesis; visual perception; positive regulation of cell proliferation; endothelial cell morphogenesis; angiogenesis; cell adhesion; response to hydrostatic pressure; positive regulation of cell migration

Disease: Knobloch Syndrome 1
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 Research Articles on COL18A1    1. High endostatin expression is associated with malignant pleural effusions in lung cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-COL18A1 antibodyDiseases associated with anti-COL18A1 antibody
 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Degradation Pathway antibodies  Collagen Degradation Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >234 publications with COL18A1 and Neoplasms, Experimental
 Lung Diseases Antibodies  >157 publications with COL18A1 and Lung Diseases
 Lung Neoplasms Antibodies  >156 publications with COL18A1 and Lung Neoplasms
 Liver Neoplasms Antibodies  >120 publications with COL18A1 and Liver Neoplasms
 Liver Diseases Antibodies  >117 publications with COL18A1 and Liver Diseases
 Neoplasm Metastasis Antibodies  >110 publications with COL18A1 and Neoplasm Metastasis
 Brain Diseases Antibodies  >76 publications with COL18A1 and Brain Diseases
 Breast Neoplasms Antibodies  >55 publications with COL18A1 and Breast Neoplasms
 Necrosis Antibodies  >53 publications with COL18A1 and Necrosis
 Carcinoma, Hepatocellular Antibodies  >52 publications with COL18A1 and Carcinoma, Hepatocellular
Organs/Tissues associated with anti-COL18A1 antibody
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >769 publications with COL18A1 and Vascular
 Blood Antibodies  >691 publications with COL18A1 and Blood
 Lung Antibodies  >219 publications with COL18A1 and Lung
 Liver Antibodies  >165 publications with COL18A1 and Liver
 Eye Antibodies  >130 publications with COL18A1 and Eye
 Embryonic Tissue Antibodies  >100 publications with COL18A1 and Embryonic Tissue
 Brain Antibodies  >92 publications with COL18A1 and Brain
 Kidney Antibodies  >83 publications with COL18A1 and Kidney
 Muscle Antibodies  >70 publications with COL18A1 and Muscle
 Bone Antibodies  >63 publications with COL18A1 and Bone
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