Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow PRG2 rightarrow Monoclonal PRG2  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Kallikrein (KLKB1) Protein
 • Cytochrome c (CYCS) Antibody
 • Cre Antibody
 • Digoxin Antibody
 • Aldose Reductase (AKR1B1) Antibody
 • IL8R beta Antibody
 • Synapsin-1 (Syn1) ELISA Kit
 • Calcium-calmodulin dependent protein kinase type II subunit ... ELISA Kit
 • VAP-1 ELISA Kit
 • Insulin-degrading enzyme (IDE) ELISA Kit
 • bone gamma-carboxyglutamate (gla) protein (BGLAP) ELISA Kit
 • Procalcitonin (PCT) ELISA Kit
 • Interleukin 8 (IL-8) ELISA Kit
 • COPZ1 Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-PRG2 antibody :: Mouse anti-Human Eosinophil Major Basic Protein Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS605399 anti-PRG2 antibody
Unit / Price
0.1 mg  /  $570 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Eosinophil Major Basic Protein (PRG2), Monoclonal Antibody

 Also Known As   

Eosinophil Major Basic Protein

 Product Synonym Names    Anti -Eosinophil Major Basic Protein
 Product Gene Name   

anti-PRG2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: 11; NC_000011.9 (57154834..57158130, complement). Location: 11q12
 OMIM    605601
 3D Structure    ModBase 3D Structure for P13727
Section Bar
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    1.B.787
 Host    Mouse
 Species Reactivity    Human
Section Bar
 Specificity    Recognizes human eosinophil major basic protein (14kD) irrespective of the stages of eosinophil activation and can be regarded as a "pan-eosinophil" marker. Recognizes the secreted pro-form of MBP (Pregnancy associated MBP, 23.8kD) and the mature form found in the matrix of the eosinophil large specific granule (13.8kD). Does not crossreact with equine, mouse or rat MBP.
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 1mg/ml BSA, 10mM sodium azide.
Section Bar
 Immunogen    Major Basic Protein
Section Bar
 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-PRG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-PRG2 antibody

   Eosinophil major basic protein is felt to play an important role in eosinophil function and perhaps endothelial injury in hypereosinophilic states. Proteoglycan 2, bone marrow, also known as PRG2, is a human gene. The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. A 117-residue protein that predominates in eosinophil granules. It is a potent enzyme against helminths and is toxic towards bacteria and mammalian cells in vitro. The eosinophil major basic protein also causes the release of histamine from mast cells and basophils, activates neutrophils and alveolar macrophages, and is directly implicated in epithelial cell damage, exfoliation and bronchospasm in asthma. Structurally the major basic protein (MBP) is similar to lectins (sugar-binding proteins), and has a fold similar to that seen in C-type lectins. However, unlike other C-type lectins (those that bind various carbohydrates in the presence of calcium), MBP does not bind either calcium or any of the other carbohydrates that this family recognize. Instead, MBP recognizes heparan sulfate proteoglycans. The structure of MBP is available from the Protein Data Bank, accession number 1h8u[2] and 2brs[3].
 Product Categories/Family for anti-PRG2 antibody    Antibodies; Abs to Cell Markers
 Applications Tested/Suitable for anti-PRG2 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-PRG2 antibody    Suitable for use in Immunohistochemistry, Western Blot and ELISA.
Dilution: Immunohistochemistry: Fresh frozen (methanol: acetone), FFPE: treat with 0.1% trypsin before blocking.
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for PRG2. It may not necessarily be applicable to this product.
 NCBI GI #    306839
 NCBI GeneID    5553
Section Bar
 UniProt Primary Accession #    P13727 [Other Products]
 UniProt Secondary Accession #    P81448; Q14227; Q6ICT2 [Other Products]
 UniProt Related Accession #    P13727 [Other Products]
 Molecular Weight    25,206 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    eosinophil major basic protein
 NCBI Official Synonym Full Names    proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
 NCBI Official Symbol    PRG2 [Similar Products]
 NCBI Official Synonym Symbols   
MBP; BMPG; MBP1; MGC14537
[Similar Products]
 NCBI Protein Information    bone marrow proteoglycan; OTTHUMP00000234774; OTTHUMP00000234775; OTTHUMP00000234776; bone-marrow proteoglycan; proteoglycan 2 preproprotein; natural killer cell activator; eosinophil major basic protein; eosinophil granule major basic protein
 UniProt Protein Name    Bone marrow proteoglycan
 UniProt Synonym Protein Names   
Proteoglycan 2Cleaved into the following chain:Eosinophil granule major basic protein; EMBP; MBP; Alternative name(s):; Pregnancy-associated major basic protein
 Protein Family    Bone marrow proteoglycan
 UniProt Gene Name    PRG2 [Similar Products]
 UniProt Synonym Gene Names    MBP [Similar Products]
 UniProt Entry Name    PRG2_HUMAN
Section Bar
 NCBI Summary for PRG2    The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. [provided by RefSeq]
Section Bar
 UniProt Comments for PRG2    PRG2: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.

Protein type: Vesicle; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: transport vesicle; extracellular region

Molecular Function: heparin binding; carbohydrate binding

Biological Process: positive regulation of interleukin-4 production; negative regulation of interleukin-10 production; defense response to bacterium; immune response; defense response to nematode
Table BarTOPTable Bar
 Research Articles on PRG2    1. The expression of MBP in nasal mucus obtained from chronic rhinosinusitispatients was obviously higher than that of nasal mucus obtained from controls.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-PRG2 antibodyPathways associated with anti-PRG2 antibody
 Reference Product  PubMed Publications
 PAPPA antibody  >1 publications with PRG2 and PAPPA
 AGT antibody  >1 publications with PRG2 and AGT
 Products by Pathway  Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
Diseases associated with anti-PRG2 antibodyOrgans/Tissues associated with anti-PRG2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5 publications with PRG2 and Neoplasms
 Leukemia, Myeloid Antibodies  >3 publications with PRG2 and Leukemia, Myeloid
 Hypertension Antibodies  >3 publications with PRG2 and Hypertension
 Leukemia, Myeloid, Acute Antibodies  >3 publications with PRG2 and Leukemia, Myeloid, Acute
 Leukemia Antibodies  >3 publications with PRG2 and Leukemia
 Inflammation Antibodies  >2 publications with PRG2 and Inflammation
 Myocardial Ischemia Antibodies  >1 publications with PRG2 and Myocardial Ischemia
 Fibrosis Antibodies  >1 publications with PRG2 and Fibrosis
 Congenital Abnormalities Antibodies  >1 publications with PRG2 and Congenital Abnormalities
 Lymphoma Antibodies  >1 publications with PRG2 and Lymphoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >23 publications with PRG2 and Blood
 Bone Marrow Antibodies  >4 publications with PRG2 and Bone Marrow
 Vascular Antibodies  >1 publications with PRG2 and Vascular
 Heart Antibodies  >1 publications with PRG2 and Heart
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions